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    Oxatomide

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    PharmaCompass
    $ API Ref.Price (USD/KG) : 197Xls

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    2D Structure
    Also known as: 60607-34-3, Tinset, Celtect, Cobiona, Dasten, Kw-4354
    Molecular Formula
    C27H30N4O
    Molecular Weight
    426.6  g/mol
    InChI Key
    BAINIUMDFURPJM-UHFFFAOYSA-N
    FDA UNII
    J31IL9Z2EE
    Oxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
    2.1.2 InChI
    InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
    2.1.3 InChI Key
    BAINIUMDFURPJM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C5
    2.2 Other Identifiers
    2.2.1 UNII
    J31IL9Z2EE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Kw 4354

    2. Kw-4354

    3. Oxatimide

    4. R 35443

    5. R35443

    6. Tinset

    2.3.2 Depositor-Supplied Synonyms

    1. 60607-34-3

    2. Tinset

    3. Celtect

    4. Cobiona

    5. Dasten

    6. Kw-4354

    7. 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1h-benzimidazol-2-one

    8. 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2h-benzimidazol-2-one

    9. R-35443

    10. R 35,443

    11. 1-(3-(4-benzhydrylpiperazin-1-yl)propyl)-1h-benzo[d]imidazol-2(3h)-one

    12. Oxatimide

    13. Nsc-309710

    14. 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone

    15. J31il9z2ee

    16. 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidazol-2-one

    17. Mls000028549

    18. Oxatomidum

    19. Oxatomida

    20. Ncgc00015774-03

    21. Smr000058301

    22. 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-2-benzimidazolinone

    23. Oxatomidum [inn-latin]

    24. 2h-benzimidazol-2-one, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-

    25. Dsstox_cid_25181

    26. Dsstox_rid_80729

    27. Dsstox_gsid_45181

    28. Oxatomida [inn-spanish]

    29. Mcn-jr 35443

    30. R 35443

    31. Celtect (tn)

    32. Cas-60607-34-3

    33. Einecs 262-320-9

    34. Cbmicro_024634

    35. Unii-j31il9z2ee

    36. Brn 4724760

    37. Oxatomide (jan/usan/inn)

    38. 1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1,3-dihydro-2h-benzimidazol-2-one

    39. Oxatomide [usan:inn:ban:jan]

    40. Oxatomide, >=99%

    41. Oxatomide [inn]

    42. Oxatomide [jan]

    43. Oxatomide [mi]

    44. Oxatomide [usan]

    45. Lopac-o-9387

    46. Oxatomide [mart.]

    47. O 9387

    48. Cid_4615

    49. Oxatomide [who-dd]

    50. Lopac0_000924

    51. Oprea1_338592

    52. Regid_for_cid_4615

    53. Schembl28824

    54. Chembl13828

    55. Dtxsid4045181

    56. Bdbm76863

    57. Chebi:31943

    58. Hms2089n07

    59. Hms2231h12

    60. Hms3372k08

    61. Tox21_110219

    62. Ccg-11811

    63. Nsc309710

    64. Nsc771641

    65. Zinc19632896

    66. Akos000507212

    67. Tox21_110219_1

    68. Ab04841

    69. Db12877

    70. Ks-1375

    71. Nsc 309710

    72. Nsc-771641

    73. 2h-benzimidazol-2-one, 1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-

    74. Ncgc00015774-01

    75. Ncgc00015774-02

    76. Ncgc00015774-04

    77. Ncgc00015774-05

    78. Ncgc00015774-06

    79. Ncgc00094235-01

    80. Ncgc00094235-02

    81. Bim-0024581.p001

    82. Db-053668

    83. Hy-123205

    84. Cs-0081837

    85. Eu-0100924

    86. Ft-0630723

    87. D01773

    88. Ab01227629-02

    89. 607o343

    90. A832804

    91. Sr-01000076051

    92. Q2071515

    93. Sr-01000076051-1

    94. W-105243

    95. 3-[3-(4-benzhydrylpiperazino)propyl]-1h-benzimidazol-2-one

    96. 3-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1h-benzimidazol-2-one

    97. 3-[3-[4-(diphenylmethyl)piperazin-1-yl]propyl]-1h-benzimidazol-2-one

    98. 1-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1,3-dihydro-2h-benzimidazol-2-one

    99. 1-{3-[4-(diphenylmethyl)-1-piperazinyl}-propyl}-1,3-dihydro-2h-benzimidazol-2-one

    100. 1{-[4-(diphenylmethyl)-1-piperzinyl]propyl}-1,3-dihydro-2h-benzimidazol-2-one

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 426.6 g/mol
    Molecular Formula C27H30N4O
    XLogP34.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count7
    Exact Mass426.24196159 g/mol
    Monoisotopic Mass426.24196159 g/mol
    Topological Polar Surface Area38.8 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity575
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Asthmatic Agents

    Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    4.2 ATC Code

    R - Respiratory system

    R06 - Antihistamines for systemic use

    R06A - Antihistamines for systemic use

    R06AE - Piperazine derivatives

    R06AE06 - Oxatomide