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    Oxprenolol

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 6452-73-9, Trasicor, Oxprenolol hcl, Evinrozit, Ranidrox, Rixiprol
    Molecular Formula
    C15H24ClNO3
    Molecular Weight
    301.81  g/mol
    InChI Key
    COAJXCLTPGGDAJ-UHFFFAOYSA-N
    FDA UNII
    F4XSI7SNIU
    A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3;/h4-8,12-13,16-17H,1,9-11H2,2-3H3;1H
    2.1.3 InChI Key
    COAJXCLTPGGDAJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=CC=C1OCC=C)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    F4XSI7SNIU
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Coretal

    2. Hydrochloride, Oxprenolol

    3. Koretal

    4. Oxprenolol

    5. Slow Trasicor

    6. Tevacor

    7. Trasicor

    8. Trasicor, Slow

    2.3.2 Depositor-Supplied Synonyms

    1. 6452-73-9

    2. Trasicor

    3. Oxprenolol Hcl

    4. Evinrozit

    5. Ranidrox

    6. Rixiprol

    7. Coretal

    8. Oxprenolol.hcl

    9. Ba-39089

    10. Ciba 39089ba

    11. F4xsi7sniu

    12. Oxprenolol (hydrochloride)

    13. 2-propanol, 1-(o-allyloxyphenoxy)-3-isopropylamino-, Hydrochloride

    14. Ba-39,089

    15. 1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanol Hydrochloride

    16. 1-(2-(allyloxy)phenoxy)-3-(isopropylamino)propan-2-ol Hydrochloride

    17. (+/-)-oxprenolol (hydrochloride)

    18. 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol;hydrochloride

    19. Secondafil

    20. Vrachor

    21. Flecor

    22. Slow-trasicor

    23. Dsstox_cid_1093

    24. (+/-)-ba 39089

    25. Dsstox_rid_75936

    26. Dsstox_gsid_21093

    27. Oxiprenolol Hydrochloride

    28. Dl-alprenolol Hydrochloride

    29. Ccris 1097

    30. Unii-f4xsi7sniu

    31. C-39089-ba

    32. Einecs 229-260-5

    33. Einecs 245-358-0

    34. Ba 39089

    35. (+-)-ba 39089

    36. Okuspurecol (tn)

    37. Oxprenolol Hydrochloride [usan:usp:jan]

    38. Dl-1-(2-allylphenoxy)-3-isopropylaminopropan-2-ol Hydrochloride

    39. Ncgc00016675-01

    40. 2-(o-allyloxyphenoxy)-2-hydroxy-n-isopropyl-1-propylamine Hydrochloride

    41. 2-propanol, 1-(o-(allyloxy)phenoxy)-3-(isopropylamino)-, Hydrochloride, (+-)-

    42. Cas-6452-73-9

    43. 2-propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-, Hydrochloride

    44. 2-propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-, Hydrochloride, (+-)-

    45. Mls002154132

    46. Schembl123517

    47. Chembl1200745

    48. Dtxsid5021093

    49. Hms1571c16

    50. Hy-b1486

    51. Tox21_110556

    52. Mfcd00058008

    53. Oxprenolol Hydrochloride [mi]

    54. Oxprenolol Hydrochloride (jp17/usp)

    55. Oxprenolol Hydrochloride [jan]

    56. (1)-(3-(2-(allyloxy)phenoxy)-2-hydroxypropyl)isopropylammonium Chloride

    57. Akos015994696

    58. Tox21_110556_1

    59. Ccg-221057

    60. Ks-1152

    61. Oxprenolol Hydrochloride [usan]

    62. 1-[(1-methylethyl)amino]-3-{[2-(prop-2-en-1-yloxy)phenyl]oxy}propan-2-ol Hydrochloride

    63. Ncgc00179342-03

    64. Oxprenolol Hydrochloride [usp-rs]

    65. Oxprenolol Hydrochloride [who-dd]

    66. 22972-97-0

    67. Smr001233439

    68. Db-054683

    69. Cs-0013185

    70. Ft-0630349

    71. Sw219956-1

    72. Oxprenolol Hydrochloride [ep Impurity]

    73. Oxprenolol Hydrochloride [orange Book]

    74. D01806

    75. Oxprenolol Hydrochloride [usp Impurity]

    76. Oxprenolol Hydrochloride [usp Monograph]

    77. Sr-01000841263

    78. Sr-01000841263-2

    79. Q27277643

    80. Oxprenolol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    81. 1-(2-(allyloxy)phenoxy)-3-(isopropylamino)propan-2-ol Hcl

    82. 1-(isopropylamino)-2-hydroxy-3-[o-(allyloxy)phenoxy]propane Hydrochloride

    83. 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-2-propanol Hydrochloride

    84. 1-[(1-methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-2-propanol Hydrochloride

    85. 2-propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-, Hydrochloride (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 301.81 g/mol
    Molecular Formula C15H24ClNO3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count9
    Exact Mass301.1444713 g/mol
    Monoisotopic Mass301.1444713 g/mol
    Topological Polar Surface Area50.7 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity246
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic beta-Antagonists

    Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)