1. Brondaxin
2. Brondecon
3. Choledyl
4. Choledyl-sa
5. Choline Theophyllinate
6. Cholinetheophyllinate
7. Cholinophyllin
8. Euspirax
9. Oxtripylline-sa
10. Theobret
1. Choline Theophyllinate
2. 4499-40-5
3. Cholinophyllin
4. Choledyl
5. Choline Theophylline
6. Theocolin
7. Choline Salt With Theophylline (1:1)
8. Oxtriphylline [usp]
9. 146-71-4
10. Nsc-760431
11. Choline Theophyllinate [inn]
12. 1,3-dimethyl-2-oxopurin-6-olate;2-hydroxyethyl(trimethyl)azanium
13. 3k045xr58x
14. Oxtriphylline (usp)
15. Choline Theophylline (jan)
16. Choline Theophyllinate (inn)
17. Cholinophylline
18. Oxtrimethylline
19. Soliphylline
20. Teofilcolina
21. Theoxylline
22. Cholegyl
23. Choline Theophylline [jan]
24. Filoral
25. Sabidal
26. Teokolin
27. 2-hydroxy-n,n,n-trimethylethanaminium 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide
28. Colina Teofillinato
29. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
30. Cholini Theophyllinas
31. Choledyl Sa 400
32. Teofilinato De Colina
33. Theophylline Cholinate
34. Oxtriphylline Pediatric
35. Choline Theophylline Salt
36. Theophyllinate De Choline
37. Colina Teofillinato [dcit]
38. Theophylline Salt Of Choline
39. Unii-3k045xr58x
40. Cholintheophyllinat
41. Theophylline, Compd. With Choline
42. Cholini Theophyllinas [inn-latin]
43. Theocolin (tn)
44. Einecs 224-798-7
45. Teofilinato De Colina [inn-spanish]
46. Zy 15061
47. Choline Thieophyllinate
48. Theophyllinate De Choline [inn-french]
49. Theophyline And Choline
50. Choline, Compd. With Theophylline (1:1)
51. Schembl4629
52. Oxtriphylline [vandf]
53. Schembl152854
54. Oxtriphylline [usp-rs]
55. Chembl1200434
56. Dtxsid20894867
57. (2-hydroxyethyl)trimethylammonium Compound With Theophylline
58. Hms2094a07
59. Pharmakon1600-01505759
60. Choline Theophyllinate [mi]
61. Oxtriphylline [orange Book]
62. Hy-b1718
63. Nsc760431
64. Oxtriphylline [usp Monograph]
65. Akos025392171
66. Choline Theophyllinate [mart.]
67. Ccg-213695
68. Choline Theophyllinate [who-dd]
69. Db01303
70. Ks-1426
71. Nsc 760431
72. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 3,7-dihydro-1,3-dimethylpurine-2,6-dione
73. 1h-purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, Ion(1-), 2-hydroxy-n,n,n-trimethylethanaminium
74. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione (1:1)
75. Cs-0013721
76. D02017
77. Choline, Hydroxide, Compd. With Theophylline (1:1)
78. Q5104342
79. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 3,9-dihydro-1,3-dimethyl-1h-purine-2,6-dione (1:1)
| Molecular Weight | 283.33 g/mol |
|---|---|
| Molecular Formula | C12H21N5O3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 283.16443955 g/mol |
| Monoisotopic Mass | 283.16443955 g/mol |
| Topological Polar Surface Area | 91.6 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 415 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.
Bronchodilator Agents
Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03D - Other systemic drugs for obstructive airway diseases
R03DA - Xanthines
R03DA02 - Choline theophyllinate
Absorption
After ingestion, theophylline is released from oxytriphylline in the acidic environment of the stomach.
Route of Elimination
The kidneys are the main route of elimination for both theophylline and its metabolites, but some unchanged theophylline is eliminated in the feces.
Volume of Distribution
Theophylline has an apparent volume of distribution of 0.30.7 L/kg in children and adults, and the Vd is about twice that of an adult in premature infants.
Clearance
Theophylline has an average clearance in children (over 6 months) of 1.45 mL/kg per minute, and in healthy, nonsmoking adults of 0.65 mL/kg per hour.
Theophylline undergoes hepatic metabolism to 1,3-dimethyluric acid, 1-methyluric acid, and 3-methylxanthine.
The serum half life varies greatly between patients and in age. The half life range for a healthy, nonsmoking adult is 3-12.8 hours, for children is 1.59.5 hours, and for for premature infants is 1558 hours.
Oxtriphylline is a choline salt of theophylline. After ingestion, theophylline is released from oxytriphylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
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