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    Oxymetazoline Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 2315-02-8, Oxymetazoline hcl, Ocuclear, Afrazine, Afrin hydrochloride, Sch 9384
    Molecular Formula
    C16H25ClN2O
    Molecular Weight
    296.83  g/mol
    InChI Key
    BEEDODBODQVSIM-UHFFFAOYSA-N
    FDA UNII
    K89MJ0S5VY
    A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride
    2.1.2 InChI
    InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
    2.1.3 InChI Key
    BEEDODBODQVSIM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    K89MJ0S5VY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrochloride, Oxymetazoline

    2. Oxymetazoline

    2.3.2 Depositor-Supplied Synonyms

    1. 2315-02-8

    2. Oxymetazoline Hcl

    3. Ocuclear

    4. Afrazine

    5. Afrin Hydrochloride

    6. Sch 9384

    7. Rhofade

    8. Oxymetazoline (hydrochloride)

    9. Visine L.r.

    10. Vicks Sinex

    11. Nsc-757254

    12. K89mj0s5vy

    13. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride

    14. Mls000038040

    15. Chebi:7863

    16. Agn-199201

    17. Sch-9384

    18. Smr000059324

    19. 2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

    20. 2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

    21. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Monohydrochloride

    22. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

    23. Phenol, 3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, Monohydrochloride

    24. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline

    25. Lliadine

    26. Nasivin

    27. Nasivine

    28. Neonabel

    29. Nostrilla

    30. Nafrine Hydrochloride

    31. 4-way Nasal Spray

    32. Duration Nasal Spray

    33. Oxymetazoline Chloride

    34. Lliadin Mini Paediatric

    35. Sr-01000002705

    36. Neo-synephrine 12 Hour

    37. Neo-synephrine 12 Hour Ntz

    38. Sinex

    39. Anefrin Nasal

    40. Duration 12 Hour Nasal Spray

    41. Benzedrex Nasal Spray 12 Hour

    42. Dristan Long Lasting Nasal Mist

    43. Sudafed Om

    44. Ocuclear (tn)

    45. Prestwick_373

    46. Einecs 219-015-0

    47. St. Joseph Nasal Spray For Children

    48. Mfcd00058147

    49. Rhfade (tn)

    50. Upneeq

    51. Opera_id_32

    52. 2-(3-hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline Hydrochloride

    53. Unii-k89mj0s5vy

    54. 3-[(4,5-dihydro-

    55. Schembl41247

    56. Mls002222207

    57. Spectrum1500453

    58. Oxymetazoline Hydrochloride,(s)

    59. Chembl1200791

    60. Hy-b0427a

    61. Dtxsid80177729

    62. Oximetazoline Hydrochloride

    63. Hms1568n09

    64. Hms1920d18

    65. Pharmakon1600-01500453

    66. Tox21_500903

    67. Ccg-40216

    68. Nsc757254

    69. 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

    70. Akos000280887

    71. Oxymetazoline Hydrochloride (jan/usp)

    72. Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, Hydrochloride

    73. Ks-5222

    74. Lp00903

    75. Nsc 757254

    76. Oxymetazoline Hydrochloride [mi]

    77. Ncgc00094218-01

    78. Ncgc00094218-02

    79. Ncgc00094218-03

    80. Ncgc00094218-04

    81. Ncgc00094218-05

    82. Ncgc00261588-01

    83. Oxymetazoline Hydrochloride [jan]

    84. 2315-02-8 (hcl)

    85. Oxymetazoline Hydrochloride [usan]

    86. Oxymetazoline Hydrochloride [mart.]

    87. Oxymetazoline Hydrochloride [vandf]

    88. 4-(2-boc-amino-pyridin-4-yl)-benzoicacid

    89. Oxymetazoline Hydrochloride [who-dd]

    90. Oxymetazoline Hydrochloride, >=99%, Solid

    91. Eu-0100903

    92. Ft-0673462

    93. O0520

    94. Oxymetazoline Hydrochloride [usan:usp:jan]

    95. Sw196632-3

    96. D01022

    97. D91882

    98. O 2378

    99. Oxymetazoline Hydrochloride, Analytical Standard

    100. Oxymetazoline Hydrochloride [orange Book]

    101. 315o028

    102. A910982

    103. Oxymetazoline Hydrochloride [ep Monograph]

    104. Oxymetazoline Hydrochloride [usp Impurity]

    105. Oxymetazoline Hydrochloride [usp Monograph]

    106. Kovanaze Component Oxymetazoline Hydrochloride

    107. Sr-01000002705-2

    108. Sr-01000002705-4

    109. Sr-01000002705-7

    110. W-107424

    111. Q27107602

    112. Oxymetazoline Hydrochloride Component Of Kovanaze

    113. Sinex Vapospray Moisturizing 12-hour Decongestant Ultrafine Mist

    114. 2,6-dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

    115. 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

    116. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

    117. Oxymetazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    118. 1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol Hydrochloride

    119. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline Hydrochloride

    120. 2-(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-4,5-dihydro-1h-imidazol-1-ium Chloride

    121. 6-(tert-butyl)-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

    122. 6-tert-butyl-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

    123. Oxymetazoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    124. Oxymetazoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    125. 3-[(4,5-dihydro-1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 296.83 g/mol
    Molecular Formula C16H25ClN2O
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass296.1655411 g/mol
    Monoisotopic Mass296.1655411 g/mol
    Topological Polar Surface Area44.6 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity345
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Nasal Decongestants

    Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Adrenergic alpha-Agonists

    Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Increased Sympathetic Activity [PE]; Vasoconstriction [PE]; Vasoconstrictor [EPC]; Imidazolines [CS]