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    Oxymorphone HCl

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    PATENTS & EXCLUSIVITIES

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: Oxymorphone hcl, 357-07-3, Opana er, Oxymorphone hydrochloride [usp], 5y2ei94nbc, Oxymorphone hcl narcotic analgesic
    Molecular Formula
    C17H20ClNO4
    Molecular Weight
    337.8  g/mol
    InChI Key
    BCGJBQBWUGVESK-KCTCKCTRSA-N
    FDA UNII
    5Y2EI94NBC
    An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19NO4.ClH/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9;/h2-3,12,15,19,21H,4-8H2,1H3;1H/t12-,15+,16+,17-;/m1./s1
    2.1.3 InChI Key
    BCGJBQBWUGVESK-KCTCKCTRSA-N
    2.1.4 Canonical SMILES
    CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
    2.1.5 Isomeric SMILES
    CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    5Y2EI94NBC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Numorphan

    2. Opana

    3. Oxymorphone

    4. Oxymorphone Hcl

    2.3.2 Depositor-Supplied Synonyms

    1. Oxymorphone Hcl

    2. 357-07-3

    3. Opana Er

    4. Oxymorphone Hydrochloride [usp]

    5. 5y2ei94nbc

    6. Oxymorphone Hcl Narcotic Analgesic

    7. Oxymorphone Hydrochloride (usp)

    8. Oxymorphinone Hydrochloride

    9. (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride

    10. Einecs 206-610-5

    11. Unii-5y2ei94nbc

    12. Numorphan (tn)

    13. Opana (tn)

    14. 4,5-alpha-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride

    15. 4,5alpha-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride

    16. Schembl41770

    17. Chebi:7866

    18. Chembl1200794

    19. Dtxsid10189214

    20. Oxymorphone Hydrochloride [mi]

    21. (5alpha)-4,5-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride

    22. Morphinan-6-one, 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-, Hydrochloride

    23. Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, Hydrochloride, (5alpha)-

    24. Oxymorphone Hydrochloride [mart.]

    25. Oxymorphone Hydrochloride [vandf]

    26. Oxymorphone Hydrochloride [who-dd]

    27. Oxymorphone Hydrochloride [green Book]

    28. D00844

    29. Oxymorphone Hydrochloride [orange Book]

    30. Oxymorphone Hydrochloride [usp Monograph]

    31. Q27263031

    32. 4,5.alpha.-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride

    33. Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, Hydrochloride, (5.alpha.)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 337.8 g/mol
    Molecular Formula C17H20ClNO4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count0
    Exact Mass337.1080858 g/mol
    Monoisotopic Mass337.1080858 g/mol
    Topological Polar Surface Area70 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity539
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameOpana
    PubMed HealthOxymorphone (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release, is a semi-synthetic opioid analgesic supplied in 5 mg, 10 mg, 20 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorphone hydrochloride per...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength1mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyEndo Pharms

    2 of 6  
    Drug NameOpana er
    PubMed HealthOxymorphone (By mouth)
    Drug ClassesAnalgesic
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release is a semi-synthetic opioid analgesic supplied in 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorpho...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength7.5mg; 30mg; 15mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyEndo Pharms

    3 of 6  
    Drug NameOxymorphone hydrochloride
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release, is a semi-synthetic opioid analgesic supplied in 5 mg, 10 mg, 20 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorphone hydrochloride per...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength7.5mg; 30mg; 15mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyAvanthi; Teva; Mallinckrodt; Roxane; Actavis Elizabeth; Impax Labs

    4 of 6  
    Drug NameOpana
    PubMed HealthOxymorphone (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release, is a semi-synthetic opioid analgesic supplied in 5 mg, 10 mg, 20 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorphone hydrochloride per...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength1mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyEndo Pharms

    5 of 6  
    Drug NameOpana er
    PubMed HealthOxymorphone (By mouth)
    Drug ClassesAnalgesic
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release is a semi-synthetic opioid analgesic supplied in 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorpho...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength7.5mg; 30mg; 15mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyEndo Pharms

    6 of 6  
    Drug NameOxymorphone hydrochloride
    Drug LabelOPANA ER (oxymorphone hydrochloride) extended-release, is a semi-synthetic opioid analgesic supplied in 5 mg, 10 mg, 20 mg, and 40 mg tablet strengths for oral administration. The tablet strength describes the amount of oxymorphone hydrochloride per...
    Active IngredientOxymorphone hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength7.5mg; 30mg; 15mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyAvanthi; Teva; Mallinckrodt; Roxane; Actavis Elizabeth; Impax Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    Narcotics

    Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

    Adjuvants, Anesthesia

    Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Opioid Agonist [EPC]; Full Opioid Agonists [MoA]