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    Pantoprazole Sodium

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

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    $ API Ref.Price (USD/KG) : 139Xls

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    2D Structure
    Also known as: 138786-67-1, Pantoloc, Protonix, Pantecta, Zurcal, Pantoprazole sodium salt
    Molecular Formula
    C16H14F2N3NaO4S
    Molecular Weight
    405.4  g/mol
    InChI Key
    YNWDKZIIWCEDEE-UHFFFAOYSA-N
    2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
    2.1.2 InChI
    InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
    2.1.3 InChI Key
    YNWDKZIIWCEDEE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. By 1023

    2. By-1023

    3. By1023

    4. Pantoprazole

    5. Protonix

    6. Sk And F 96022

    7. Sk And F-96022

    8. Sk And F96022

    9. Skf 96022

    10. Skf-96022

    11. Skf96022

    2.2.2 Depositor-Supplied Synonyms

    1. 138786-67-1

    2. Pantoloc

    3. Protonix

    4. Pantecta

    5. Zurcal

    6. Pantoprazole Sodium Salt

    7. Skf96022 Sodium

    8. By-1023 Sodium

    9. Chebi:50270

    10. Sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

    11. Pantozol Control

    12. 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) Sulfinyl)-1h-benzimidazole Sodium

    13. Dsstox_cid_24215

    14. Dsstox_rid_80123

    15. Dsstox_gsid_44215

    16. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

    17. Sodium 5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)benzo[d]imidazol-1-ide

    18. Cas-138786-67-1

    19. Anagastra

    20. Inipomp

    21. Pantorc

    22. Peptazol

    23. Ulcotenal

    24. Citrel

    25. Apton

    26. Rifun

    27. Pantoprazole Sodium;

    28. By1023 (sodium)

    29. Pantoprazole Sodium,(s)

    30. Skf96022 (sodium)

    31. Schembl3543

    32. Mls001424073

    33. Pantoprazole Sodium Monohydrate

    34. Chembl1200408

    35. Dtxsid7044215

    36. Dz-2352a

    37. Hms2051l19

    38. Hms3393l19

    39. Hms3715d12

    40. Act02633

    41. Tox21_112996

    42. Tox21_302362

    43. Mfcd01658543

    44. S4538

    45. Akos015994677

    46. Ccg-100980

    47. Ks-1093

    48. Nc00230

    49. S86p671

    50. Sb17369

    51. By-1023/sk&f-96022

    52. Ncgc00255835-01

    53. Smr000469592

    54. Ft-0602602

    55. Ft-0673508

    56. A807440

    57. B-8610-23/sk&f-96022-z

    58. J-516336

    59. B-8510-29

    60. Q27122012

    61. Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl] Benzimidazol-1-ide

    62. 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1h-benzo[d]imidazole, Sodium Salt

    63. 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]benzimidazol-1-ide; Sodium;pantoprazole Sodium

    64. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole

    65. Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide

    2.2.3 Other Synonyms

    1. Pantozol

    2. S-pantoprazole

    3. Pantoprazole

    2.3 Create Date
    2007-02-09
    3 Chemical and Physical Properties
    Molecular Weight 405.4 g/mol
    Molecular Formula C16H14F2N3NaO4S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count7
    Exact Mass405.05707772 g/mol
    Monoisotopic Mass405.05707772 g/mol
    Topological Polar Surface Area90.8 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity497
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NamePantoprazole sodium
    Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
    Active IngredientPantoprazole sodium
    Dosage FormInjectable; Tablet, delayed release
    Routeinjection; Iv (infusion); Oral
    Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

    2 of 4  
    Drug NameProtonix iv
    Active IngredientPantoprazole sodium
    Dosage FormInjectable
    RouteIv (infusion)
    Strengtheq 40mg base/vial
    Market StatusPrescription
    CompanyWyeth Pharms

    3 of 4  
    Drug NamePantoprazole sodium
    Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
    Active IngredientPantoprazole sodium
    Dosage FormInjectable; Tablet, delayed release
    Routeinjection; Iv (infusion); Oral
    Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

    4 of 4  
    Drug NameProtonix iv
    Active IngredientPantoprazole sodium
    Dosage FormInjectable
    RouteIv (infusion)
    Strengtheq 40mg base/vial
    Market StatusPrescription
    CompanyWyeth Pharms

    4.2 Drug Indication

    Short-term treatment of reflux symptoms (e. g. heartburn, acid regurgitation) in adults.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    Proton Pump Inhibitors

    Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Proton Pump Inhibitors [MoA]; Proton Pump Inhibitor [EPC]
    5.3 ATC Code

    A02BC02