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    Papaverine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

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    $ API Ref.Price (USD/KG) : 469Xls

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    2D Structure
    Also known as: 61-25-6, Cardoverina, Cardiospan, Papaversan, Artegodan, Forpavin
    Molecular Formula
    C20H22ClNO4
    Molecular Weight
    375.8  g/mol
    InChI Key
    UOTMYNBWXDUBNX-UHFFFAOYSA-N
    FDA UNII
    23473EC6BQ
    An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride
    2.1.2 InChI
    InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
    2.1.3 InChI Key
    UOTMYNBWXDUBNX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    23473EC6BQ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cerespan

    2. Hydrochloride, Papaverine

    3. Papaverine

    4. Pavabid

    5. Pavatym

    2.3.2 Depositor-Supplied Synonyms

    1. 61-25-6

    2. Cardoverina

    3. Cardiospan

    4. Papaversan

    5. Artegodan

    6. Forpavin

    7. Papalease

    8. Pavatest

    9. Pavabid

    10. Dispamil

    11. Drapavel

    12. Paverolan

    13. Alapav

    14. Cerebid

    15. Delapav

    16. Dilaves

    17. Durapav

    18. Dynovas

    19. Myobid

    20. Pameion

    21. Papacon

    22. Pavacap

    23. Pavacen

    24. Paveron

    25. Pavnell

    26. Vasal

    27. Papaverine Hcl

    28. Ro-papav

    29. Vaso-pav

    30. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline Hydrochloride

    31. Cerespan

    32. Papaverinium Chloride

    33. Papanerin-hcl

    34. Papavarine Chlorhydrate

    35. Pap-kaps-150

    36. Papaverine Chlorohydrate

    37. Papaverine, Hcl

    38. Pap H

    39. Papaverine (hydrochloride)

    40. Papaverine Monohydrochloride

    41. Nci-c56359

    42. Vasorin

    43. Chlorhydrate De Papaverine

    44. Nsc 35443

    45. 6,7-dimethoxy-1-veratrylisoquinoline Hydrochloride

    46. Nsc-35443

    47. Mls000028497

    48. 23473ec6bq

    49. Cepaverin

    50. Optenyl

    51. Pavagrant

    52. Pavakey

    53. Pavased

    54. Smr000058283

    55. Therapav

    56. Dipav

    57. Lapav

    58. Dsstox_cid_5825

    59. Spasmo-nit

    60. Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, Hydrochloride

    61. Dsstox_rid_77939

    62. Dsstox_gsid_25825

    63. Papanerin-hcl [german]

    64. 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride

    65. Nsc35443

    66. Ccris 3804

    67. Cas-61-25-6

    68. Sr-01000003098

    69. Chlorhydrate De Papaverine [french]

    70. Ncgc00015810-02

    71. Einecs 200-502-1

    72. Pamelon

    73. Unii-23473ec6bq

    74. Papaverine Hydrochloride [jan]

    75. Qua Bid

    76. Prestwick_376

    77. Papaverine Hydrochloride [usp:jan]

    78. Pavabid (tn)

    79. Component Of Copavin

    80. Mfcd00012745

    81. Isoquinoline, 6,7-dimethoxy-1-veratryl-, Hydrochloride

    82. 6,7,3',4'-tetramethoxy-1-benzylisoquinoline Hydrochloride

    83. Papaverini Hydrochloridum

    84. Papaverine, Hydrochloride

    85. Opera_id_1617

    86. Regid_for_cid_6084

    87. Mls001148655

    88. Mls002222208

    89. Chembl98123

    90. Schembl121268

    91. Spectrum1500459

    92. Papaverine Hydrochloride, Powder

    93. Dtxsid9025825

    94. Cas 61-25-6

    95. Hms1569f08

    96. Hms1920f06

    97. Pharmakon1600-01500459

    98. Tox21_110226

    99. Tox21_500957

    100. Ccg-40065

    101. Hy-18077a

    102. Nsc757256

    103. Papaverine Hydrochloride [mi]

    104. Papaverine Hydrochloride (jp17/usp)

    105. Akos005111070

    106. Tox21_110226_1

    107. Cs-5015

    108. Lp00957

    109. Nsc-757256

    110. Papaverine Hydrochloride [hsdb]

    111. Papaverine Hydrochloride [mart.]

    112. Papaverine Hydrochloride [vandf]

    113. Ncgc00015810-12

    114. Ncgc00094258-01

    115. Ncgc00094258-02

    116. Ncgc00094258-03

    117. Ncgc00094258-04

    118. Ncgc00094258-05

    119. Ncgc00094258-06

    120. Ncgc00261642-01

    121. Papaverine Hydrochloride [usp-rs]

    122. Papaverine Hydrochloride [who-dd]

    123. Papaverine Hydrochloride [who-ip]

    124. As-13262

    125. 1-(3,7-dimethoxyisoquinoline Hydrochloride

    126. Db-053821

    127. Eu-0100957

    128. P0016

    129. D02218

    130. D86684

    131. P 3510

    132. Papaverine Hydrochloride [ep Monograph]

    133. Papaverine Hydrochloride [usp Monograph]

    134. Papaverini Hydrochloridum [who-ip Latin]

    135. Isoquinoline,7-dimethoxy-1-veratryl-, Hydrochloride

    136. Sr-01000003098-2

    137. Sr-01000003098-4

    138. Sr-01000003098-9

    139. Wln: T66 Cnj B1r Co1 Do1& Ho1 Io1 &gh

    140. Q27253713

    141. Sr-01000003098-11

    142. 6,3',4'-tetramethoxy-1-benzylisoquinoline Hydrochloride

    143. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinolinehydrochloride

    144. Isoquinoline,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, Hydrochloride

    145. Papaverine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    146. Papaverine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    147. Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, Hydrochloride (1:1)

    148. Papaverine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    149. Papaverine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 375.8 g/mol
    Molecular Formula C20H22ClNO4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass375.1237359 g/mol
    Monoisotopic Mass375.1237359 g/mol
    Topological Polar Surface Area49.8 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity407
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Phosphodiesterase Inhibitors

    Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)