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    Paromomycin Sulfate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 1263-89-4, Paromomycin sulfate salt, Aminosidine sulfate, Gabbroral, Humatin, Aminosidin sulfate
    Molecular Formula
    C23H47N5O18S
    Molecular Weight
    713.7  g/mol
    InChI Key
    LJRDOKAZOAKLDU-UDXJMMFXSA-N
    FDA UNII
    845NU6GJPS
    An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
    2.1.2 InChI
    InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
    2.1.3 InChI Key
    LJRDOKAZOAKLDU-UDXJMMFXSA-N
    2.1.4 Canonical SMILES
    C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    845NU6GJPS
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aminosidine

    2. Beta-d-glucopyranosyl-isomer Paromomycin

    3. Catenulin

    4. Estomycin

    5. Gabbromycin

    6. Humatin

    7. Hydroxymycin

    8. Neomycin E

    9. Paramomycin

    10. Paromomycin

    11. Paromomycin I

    12. Paromomycin Phosphate

    13. Paromomycin Sulfate (1:1)

    14. Paromomycin Sulfate (2:5)

    15. Paromomycin, Beta D Glucopyranosyl Isomer

    16. Paromomycin, Beta-d-glucopyranosyl-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 1263-89-4

    2. Paromomycin Sulfate Salt

    3. Aminosidine Sulfate

    4. Gabbroral

    5. Humatin

    6. Aminosidin Sulfate

    7. Gabbromicina

    8. Farmiglucin

    9. Farminosidin

    10. Aminoxidin

    11. Humagel

    12. Sinosid

    13. Aminosidine Sulphate

    14. Paromomycin (sulfate)

    15. Paromomycin Sulphate

    16. 845nu6gjps

    17. Paromomycin, Sulfate (1:1)

    18. 7205-49-4

    19. Gabbromycin

    20. Pargonyl

    21. Fi 5853

    22. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((2r,3s,4r,5s)-5-(((1r,2r,3s,5r,6s)-3,5-diamino-2-(((2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2h-pyran-3,4-diol Sulfate

    23. Humycin Sulfate

    24. Nsc-758421

    25. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((2r,3s,4r,5s)-5-(((1r,2r,3s,5r,6s)-3,5-diamino-2-(((2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2h-pyran-3,4-diol Sulfate(1:x)

    26. Paromomycin Sulphates

    27. Mfcd00079278

    28. Paromomycin Sulfate [jan]

    29. Unii-845nu6gjps

    30. Paramicina

    31. Paricina

    32. Paromomycin Sulfate [usp:jan]

    33. 1600 Antibiotic

    34. Einecs 215-031-7

    35. Humatin (tn)

    36. Paromomycine Sulphate

    37. Aminosidine Sulfate;paromomycin Sulfate Salt

    38. Estomycin Sulfate

    39. Crestomycin Sulfate

    40. Ncgc00166210-01

    41. Cas-1263-89-4

    42. Schembl3355

    43. Dsstox_cid_27806

    44. Dsstox_rid_82574

    45. Dsstox_gsid_47829

    46. Paromomycin Sulphate (1:1)

    47. Mls000028384

    48. Penicillamine [who-ip]

    49. Chebi:7935

    50. Paromomycin Sulfate (jan/usp)

    51. Chembl2206196

    52. Paromomycin Sulfate [mi]

    53. Dtxsid601335979

    54. Paromomycin Sulfate [vandf]

    55. Hy-b0956

    56. Paromomycin Sulfate [mart.]

    57. Einecs 230-575-5

    58. Tox21_112349

    59. Paromomycin Sulfate [usp-rs]

    60. Paromomycin Sulfate [who-dd]

    61. Paromomycin Sulfate [who-ip]

    62. S4183

    63. Penicillaminum [who-ip Latin]

    64. Akos015855755

    65. Akos016009094

    66. Ccg-270398

    67. Cs-4433

    68. Fi-5853

    69. Ks-1378

    70. Nsc 758421

    71. Paromomycin Sulfate [orange Book]

    72. Smr000058551

    73. Paromomycin Sulfate [usp Monograph]

    74. Paromomycini Sulfas [who-ip Latin]

    75. D00868

    76. 263p894

    77. Q-201537

    78. Q27269495

    79. Z1551627167

    80. Hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric Acid

    81. Paromomycin Sulfate, Antibiotic For Culture Media Use Only

    82. (1r,2r,3s,4r,6s)-4,6-diamino-2-{[3-o-(2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl)-beta-d-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-d-glucopyranoside Sulfate

    83. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(

    84. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-{[(2r,3s,4r,5s)-5-{[(1r,2r,3s,5r,6s)-3,5-diamino-2-{[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; Sulfuric Acid

    85. D-streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxy-, Sulfate (1:1)

    86. D-streptamine, O-2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4)-o-(o-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-.beta.-d-ribofuranosyl-(1->5))-2-deoxy-, Sulfate (salt)

    87. D-streptamine, O-2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4)-o-(o-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-.beta.-d-ribofuranosyl-(1->5))-2-deoxy-, Sulphate (salt)

    88. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-beta-d-ribofuranosyl-(1-5))-2-deoxy-, Sulfate (salt)

    89. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1.fwdarw.3)-beta-d-ribofuranosyl-(1.fwdarw.5))-2-deoxy-, Sulfate (salt)

    90. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-1-(1-4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribofuranosyl-(1-5))-2-deoxy-, Sulfate (1:1) (salt)

    91. O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxystreptamine Sulfate (salt)

    92. O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxystreptamine Sulphate (salt)

    93. O-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribofuranosyl-(1-5)-o-(2-amino-2-deoxy-alpha-d-glucopyranosyl-(1-4))-2-deoxystreptamine Sulfate (salt)

    94. Paromomycin Sulfate Is The Sulfate Salt Of An Antibiotic Substance Or Substances Produced By The Growth Of Streptomyces Rimosus Var. Paromomycinus, Or A Mixture Of Two Or More Such Salts

    95. Paromomycin Sulphate Is The Sulphate Salt Of An Antibiotic Substance Or Substances Produced By The Growth Of Streptomyces Rimosus Var. Paromomycinus, Or A Mixture Of Two Or More Such Salts

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 713.7 g/mol
    Molecular Formula C23H47N5O18S
    Hydrogen Bond Donor Count15
    Hydrogen Bond Acceptor Count23
    Rotatable Bond Count9
    Exact Mass713.26368084 g/mol
    Monoisotopic Mass713.26368084 g/mol
    Topological Polar Surface Area430 Ų
    Heavy Atom Count47
    Formal Charge0
    Complexity952
    Isotope Atom Count0
    Defined Atom Stereocenter Count19
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameParomomycin sulfate
    Drug LabelParomomycin sulfate is a broad spectrum antibiotic produced by Streptomyces riomosus var. paromomycinus. It is a white, amorphous, stable, water-soluble product. Paromomycin sulfate is designated chemically as O-2,6-Diamino-2,6-dideoxy--L-idopyrano...
    Active IngredientParomomycin sulfate
    Dosage FormCapsule
    RouteOral
    Strengtheq 250mg base
    Market StatusPrescription
    CompanySun Pharm Inds; Heritage Pharms

    2 of 2  
    Drug NameParomomycin sulfate
    Drug LabelParomomycin sulfate is a broad spectrum antibiotic produced by Streptomyces riomosus var. paromomycinus. It is a white, amorphous, stable, water-soluble product. Paromomycin sulfate is designated chemically as O-2,6-Diamino-2,6-dideoxy--L-idopyrano...
    Active IngredientParomomycin sulfate
    Dosage FormCapsule
    RouteOral
    Strengtheq 250mg base
    Market StatusPrescription
    CompanySun Pharm Inds; Heritage Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiprotozoal Agents

    Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Antiprotozoal [EPC]