Please Wait
Applying Filters...
menu
    • menu
    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients, & custom-made solutions to our customers.

    Virtual Booth

    Contact Supplier

    Inke S.A: APIs manufacturing plant.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-21

    Virtual Booth

    Contact Supplier

    AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-14

    Virtual Booth

    Contact Supplier

    Menu

    Pegargiminase

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Peg21, 351342-08-0, Ho-peg20-oh, 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol, Peg 20, Mfcd09910396
    Molecular Formula
    C40H82O21
    Molecular Weight
    899.1  g/mol
    InChI Key
    ZHMUMDLGQBRJIW-UHFFFAOYSA-N
    Pegargiminase is an agent consisting of the arginine-degrading enzyme arginine deiminase combined with polyethylene glycol (20,000 MW) (ADI-PEG 20) with potential antineoplastic activity. Upon administration, pegargiminase breaks down the amino acid arginine into citrulline. Although arginine is a nonessential amino acid for normal human cells, certain cancer cells are autotrophic for arginine and need arginine in order to survive. Depletion of arginine may lead to an inhibition of cellular proliferation in those cancer cells. ADI is coupled to PEG in order to enhance this agent's half-life.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    2.1.2 InChI
    InChI=1S/C40H82O21/c41-1-3-43-5-7-45-9-11-47-13-15-49-17-19-51-21-23-53-25-27-55-29-31-57-33-35-59-37-39-61-40-38-60-36-34-58-32-30-56-28-26-54-24-22-52-20-18-50-16-14-48-12-10-46-8-6-44-4-2-42/h41-42H,1-40H2
    2.1.3 InChI Key
    ZHMUMDLGQBRJIW-UHFFFAOYSA-N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Adi Peg20

    2. Adi-peg20

    3. Pegylated Arginine Deiminase

    2.2.2 Depositor-Supplied Synonyms

    1. Peg21

    2. 351342-08-0

    3. Ho-peg20-oh

    4. 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

    5. Peg 20

    6. Mfcd09910396

    7. 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

    8. Pegylated Arginine Deiminase

    9. Pegargiminasum

    10. Pegargiminasa

    11. 9fo

    12. Eicosa-ethylene Glycol

    13. Adi-peg

    14. Adi-ss

    15. Adipeg20

    16. 0b7pyq9yrt

    17. Arginine Deiminase Pegylated

    18. Pegargiminase [inn]

    19. Pegargiminase [usan:inn]

    20. Adi-peg 20

    21. Adi-peg-20

    22. Pegargiminase [usan]

    23. Pegargiminase [who-dd]

    24. Schembl4595689

    25. Dtxsid301018299

    26. Akos040741840

    27. Bp-23437

    28. Da-56666

    29. Ms-31676

    30. Sy272914

    31. Hy-141236

    32. Cs-0115035

    33. Ns00076660

    34. C70465

    35. 1394129-74-8

    36. Pentakis(n-(4-(.omega.-methoxypoly(oxyethylene))-4-oxobutanoyl))-(111-glutamic Acid,209-serine)arginine Deiminase (adi, Arginine Dihydrolase, Ad) From Mycoplasma Hominis

    37. Pentakis(n-(4-(omega-methoxypoly(oxyethylene))-4-oxobutanoyl))-(111-glutamic Acid,209-serine)arginine Deiminase (adi, Arginine Dihydrolase, Ad) From Mycoplasma Hominis

    2.3 Create Date
    2007-02-09
    3 Chemical and Physical Properties
    Molecular Weight 899.1 g/mol
    Molecular Formula C40H82O21
    XLogP3-3.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count21
    Rotatable Bond Count58
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area216
    Heavy Atom Count61
    Formal Charge0
    Complexity693
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in melanoma and hepatocellular carcinoma.