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    Pemirolast

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 100299-08-9, Alamast, Pemirolast potassium salt, Pemilaston, Alegysal, Bmy 26517
    Molecular Formula
    C10H7KN6O
    Molecular Weight
    266.30  g/mol
    InChI Key
    NMMVKSMGBDRONO-UHFFFAOYSA-N
    FDA UNII
    497A17OUUE
    Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one
    2.1.2 InChI
    InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
    2.1.3 InChI Key
    NMMVKSMGBDRONO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    497A17OUUE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one

    2. 9-tbx

    3. Alamast

    4. Bmy 26517

    5. Bmy-26517

    6. Pemirolast

    7. Pemirolast Potassium Salt

    2.3.2 Depositor-Supplied Synonyms

    1. 100299-08-9

    2. Alamast

    3. Pemirolast Potassium Salt

    4. Pemilaston

    5. Alegysal

    6. Bmy 26517

    7. Bmy-26517

    8. Twt-8152

    9. 497a17ouue

    10. Tbx

    11. 100299-08-9 (potassium)

    12. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one, Potassium Salt

    13. Potassium 5-(9-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-1-ide

    14. 4h-pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1h-tetrazol-5-yl)-, Potassium Salt

    15. Dsstox_cid_26623

    16. Dsstox_rid_81773

    17. Dsstox_gsid_46623

    18. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one Potassium Salt

    19. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt

    20. Ccris 3562

    21. Cas-100299-08-9

    22. Pemirolast Potassium [usan:jan]

    23. Ncgc00167434-01

    24. Unii-497a17ouue

    25. Pemilaston (tn)

    26. Alegysal (tn)

    27. Alamast (tn)

    28. Permirolast Potassium

    29. Pemirolast Potassium- Bio-x

    30. Alamast, Pemirolast Potassium

    31. Schembl865789

    32. Chembl1201050

    33. Dtxsid7046623

    34. Hms3713g17

    35. Pemirolast Potassium [jan]

    36. Pemirolast Potassium [usan]

    37. Bcp21138

    38. Pemirolast Potassium (jp17/usan)

    39. Pemirolast Potassium [vandf]

    40. Tox21_112438

    41. Bdbm50248065

    42. De-068

    43. Pemirolast (bmy 26517) Potassium

    44. Pemirolast Potassium [mart.]

    45. Permirolast Potassium [vandf]

    46. S4008

    47. Pemirolast Potassium [who-dd]

    48. Akos015901748

    49. Pemirolast Potassium Salt [mi]

    50. Tox21_112438_1

    51. Ac-8303

    52. Ccg-220358

    53. Hs-0020

    54. Pemirolast Potassium, >=98% (hplc)

    55. Sb18793

    56. Ncgc00167434-02

    57. Ac-22387

    58. Bp164244

    59. Pemirolast Potassium [orange Book]

    60. Ft-0631005

    61. P1995

    62. P2547

    63. D01088

    64. T71519

    65. 299p089

    66. J-000087

    67. Q27259246

    68. 9-methyl-3-(2h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt;alamast

    69. Potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 266.30 g/mol
    Molecular Formula C10H7KN6O
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count1
    Exact Mass266.03184035 g/mol
    Monoisotopic Mass266.03184035 g/mol
    Topological Polar Surface Area72.3 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity495
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine Antagonists

    Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)