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    Pentylenetetrazole

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    PharmaCompass
    $ API Ref.Price (USD/KG) : 770Xls

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    2D Structure
    Also known as: Pentylenetetrazol, Pentylenetetrazole, 54-95-5, Metrazole, Cardiazol, 1,5-pentamethylenetetrazole
    Molecular Formula
    C6H10N4
    Molecular Weight
    138.17  g/mol
    InChI Key
    CWRVKFFCRWGWCS-UHFFFAOYSA-N
    FDA UNII
    WM5Z385K7T
    A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine
    2.1.2 InChI
    InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
    2.1.3 InChI Key
    CWRVKFFCRWGWCS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCC2=NN=NN2CC1
    2.2 Other Identifiers
    2.2.1 UNII
    WM5Z385K7T
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cardiazol

    2. Corasol

    3. Corazol

    4. Corazole

    5. Korazol

    6. Korazole

    7. Leptazole

    8. Metrazol

    9. Metrazole

    10. Pentamethylenetetrazole

    11. Pentazol

    12. Pentetrazole

    13. Pentylenetetrazol

    14. Pentylenetetrazole

    2.3.2 Depositor-Supplied Synonyms

    1. Pentylenetetrazol

    2. Pentylenetetrazole

    3. 54-95-5

    4. Metrazole

    5. Cardiazol

    6. 1,5-pentamethylenetetrazole

    7. Cardiazole

    8. Corazole

    9. Korazol

    10. Metrazol

    11. Pentetrazole

    12. Coranormol

    13. Korazole

    14. Leptazol

    15. Leptazole

    16. Cardiol

    17. Cenazol

    18. Corazol

    19. Coryvet

    20. Pentazol

    21. Pentamethylenetetrazole

    22. Cardiotonicum

    23. Pentamethazol

    24. Pentamethylenetetrazol

    25. Cardifortan

    26. Cardosal

    27. Cardosan

    28. Coratoline

    29. Corvasol

    30. Deumacard

    31. Diovascole

    32. Kardiazol

    33. Phrenazol

    34. Ventrazol

    35. Corasol

    36. Gewazol

    37. 6,7,8,9-tetrahydro-5h-tetrazolo[1,5-a]azepine

    38. Pentamethazolum

    39. Angiazol

    40. Centrazole

    41. Coranormal

    42. Corsedrol

    43. Deamocard

    44. Nauranzol

    45. Naurazol

    46. Nedcardol

    47. Neocardol

    48. Neurazol

    49. Pemetesan

    50. Penetrasol

    51. Pentacard

    52. Pentazolum

    53. Pentemesan

    54. Pentrazol

    55. Pentrolone

    56. Pentrozol

    57. Petrazole

    58. Phrenazone

    59. Tetracor

    60. Tetrazol

    61. Yetrazol

    62. Corisan

    63. Cortis

    64. Corvis

    65. Opticor

    66. Vasorex

    67. Cerebro-nicin

    68. Novo Cora-vinco

    69. Cenalene-m

    70. Metalex-p

    71. Corazole (analeptic)

    72. Delzol-w

    73. Pentamethylene-1,5-tetrazole

    74. Tetrazole, Pentamethylene-

    75. Tt87

    76. Penetratsol

    77. Pentetrazolum

    78. Stellacardiol

    79. Stillcardiol

    80. Angioton

    81. Lepazol

    82. Penetiazol

    83. Pentacor

    84. Petazol

    85. Petezol

    86. Alpha,beta-cyclopentamethylenetetrazole

    87. Ptz

    88. 6,7,8,9-tetrahydro-5-azepotetrazole

    89. Tetrazole, (1,5-pentanediyl)-

    90. Pentametilentetrazolo

    91. Pentetrazol [inn]

    92. 6,7,8,9-tetrahydro-5h-tetrazoloazepine

    93. 5h-tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-

    94. Cardiozol

    95. Su-zol

    96. Pentamethylenetetrazal

    97. Nsc-5729

    98. Nsc-66489

    99. 1,2,3,3a-tetrazacyclohepta-8a,2-cyclopentadiene

    100. 5h-tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-

    101. .alpha.,.beta.-cyclopentamethylenetetrazole

    102. Wm5z385k7t

    103. Chebi:34910

    104. Nsc5729

    105. 6,7,8,9-tetrahydro-5h-tetrazolo(1,5-a)azepine

    106. Nsc66489

    107. Pentetrazol (inn)

    108. 7,8,9,10-tetrazabicyclo(5.3.0)-8,10-decadiene

    109. 7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene

    110. Cas-54-95-5

    111. Ncgc00015827-06

    112. Pentetratsol

    113. Corazolum

    114. Pentrazole

    115. Tetrazole,5-pentanediyl)-

    116. Wln: T57 Annnn&tj

    117. Pmt

    118. Pentetrazolo [dcit]

    119. Pentetrazolo

    120. 6,8,9-tetrahydro-5-azepotetrazole

    121. 6,8,9-tetrahydro-5h-tetrazoloazepine

    122. Pentetrazolum [inn-latin]

    123. 5h-tetrazoloazepine,7,8,9-tetrahydro-

    124. 5h-tetrazolo[1, 6,7,8,9-tetrahydro-

    125. Pentametilentetrazolo [italian]

    126. 1,3,3a-tetrazacyclohepta-8a,2-cyclopentadiene

    127. Pentylenetetrazol [nf]

    128. 7,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene

    129. Sr-01000076073

    130. Nsc 5729

    131. Einecs 200-219-3

    132. Nsc 66489

    133. Brn 0135492

    134. Unii-wm5z385k7t

    135. Pentavet

    136. Pentylentetrazole

    137. Ai3-23994

    138. Cenalene M

    139. Delzol W

    140. Prestwick_382

    141. Mfcd00005939

    142. Pentamethylene Tetrazole

    143. Spectrum_000393

    144. Specplus_000787

    145. 5h-tetrazoloazepine, 6,7,8,9-tetrahydro-

    146. Prestwick0_000162

    147. Prestwick1_000162

    148. Prestwick2_000162

    149. Prestwick3_000162

    150. Spectrum2_001121

    151. Spectrum3_001408

    152. Spectrum4_000242

    153. Spectrum5_001338

    154. Lopac-p-6500

    155. Biomol-nt_000269

    156. Coryvet [veterinary] (tn)

    157. Dsstox_cid_21091

    158. Dsstox_rid_79624

    159. Pentetrazol [mart.]

    160. Dsstox_gsid_41091

    161. Lopac0_000940

    162. Schembl22674

    163. 1, 5-pentamethylenetetrazole

    164. 1,5-pentamethylene Tetrazole

    165. Bspbio_000023

    166. Bspbio_003056

    167. Kbiogr_000644

    168. Kbioss_000873

    169. Pentetrazol [who-dd]

    170. 4-26-00-01713 (beilstein Handbook Reference)

    171. Divk1c_006883

    172. Spectrum2300347

    173. Spbio_000981

    174. Spbio_001944

    175. Pentylenetetrazole [mi]

    176. Bpbio1_000027

    177. Bpbio1_000860

    178. Chembl116943

    179. Zinc1905

    180. Dtxsid7041091

    181. Kbio1_001827

    182. Kbio2_000873

    183. Kbio2_003441

    184. Kbio2_006009

    185. Kbio3_002276

    186. Pentylenetetrazol [vandf]

    187. Hms1568b05

    188. Hms2093p18

    189. Hms2095b05

    190. Hms3262l22

    191. Hms3269n13

    192. Hms3414p17

    193. Hms3678p15

    194. Hms3712b05

    195. Hms3885p08

    196. Pharmakon1600-02300347

    197. Amy22325

    198. Hy-b1242

    199. Tox21_110234

    200. Tox21_500940

    201. Ccg-40268

    202. Nsc759592

    203. S4587

    204. Stl356056

    205. Akos005207166

    206. Cs-4890

    207. Db13415

    208. Lp00940

    209. Nsc-759592

    210. Sb17494

    211. Sdccgsbi-0050914.p004

    212. Ncgc00015827-01

    213. Ncgc00015827-02

    214. Ncgc00015827-03

    215. Ncgc00015827-04

    216. Ncgc00015827-05

    217. Ncgc00015827-07

    218. Ncgc00015827-08

    219. Ncgc00015827-09

    220. Ncgc00015827-17

    221. Ncgc00094246-01

    222. Ncgc00094246-02

    223. Ncgc00094246-03

    224. Ncgc00094246-04

    225. Ncgc00094246-05

    226. Ncgc00261625-01

    227. As-47604

    228. 6,7,8, 9-tetrahydro-5h-tetrazoloazepine

    229. Sbi-0050914.p003

    230. Ab00052439

    231. B7152

    232. Eu-0100940

    233. P0046

    234. 5h-tetrazoloazepine, 6,7,8, 9-tetrahydro-

    235. D07409

    236. F14615

    237. P 6500

    238. Ab00052439_04

    239. Q412391

    240. 1,2,3, 3a-tetrazacyclohepta-8a,2-cyclopentadiene

    241. 1,8,9,10-tetrazabicyclo[5.3.0]deca-7,9-diene

    242. 6,7,8,9-tetrahydro-5h-tetraazolo[1,5-a]azepine

    243. 6,7,8,9-tetrahydro-5h-tetrazolo[1,5 -a]azepine

    244. Sr-01000076073-1

    245. Sr-01000076073-3

    246. Sr-01000076073-5

    247. 6,7,8,9-tetrahydro-5h-tetraazolo[1,5-a]azepine #

    248. 7,8,9,10-tetrazabicyclo[5.3.0]deca-8,10-diene

    249. Brd-k57718010-001-01-0

    250. Brd-k57718010-001-08-5

    251. {5h-tetrazolo[1,5-a]azepine,} 6,7,8,9-tetrahydro-

    252. 7,8,9, {10-tetrazabicyclo[5.3.0]-8,10-decadiene}

    253. 20192-24-9

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 138.17 g/mol
    Molecular Formula C6H10N4
    XLogP30.1
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass138.090546336 g/mol
    Monoisotopic Mass138.090546336 g/mol
    Topological Polar Surface Area43.6 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity116
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Convulsants

    Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools. (See all compounds classified as Convulsants.)

    GABA Antagonists

    Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS. (See all compounds classified as GABA Antagonists.)

    4.2 ATC Code

    R - Respiratory system

    R07 - Other respiratory system products

    R07A - Other respiratory system products

    R07AB - Respiratory stimulants

    R07AB03 - Pentetrazol