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    Perazine Maleate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    $ API Ref.Price (USD/KG) : 303Xls

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    2D Structure
    Also known as: 14516-56-4, Perazine maleate, Perazine maleate [jan], Perazine maleate (jan), 3vg1507988, (z)-but-2-enedioic acid;10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
    Molecular Formula
    C28H33N3O8S
    Molecular Weight
    571.6  g/mol
    InChI Key
    PQDKNYWKLCFCJU-SPIKMXEPSA-N
    FDA UNII
    3VG1507988
    A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
    2.1.2 InChI
    InChI=1S/C20H25N3S.2C4H4O4/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23;2*5-3(6)1-2-4(7)8/h2-5,7-10H,6,11-16H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
    2.1.3 InChI Key
    PQDKNYWKLCFCJU-SPIKMXEPSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    3VG1507988
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dihydrochloride, Perazine

    2. Maleate, Perazine

    3. Perazine

    4. Perazine Dihydrochloride

    5. Perazine Maleate

    6. Perazine Maleate (1:1)

    7. Perazine Maleate (1:2)

    8. Pernazine

    9. Taxilan

    2.3.2 Depositor-Supplied Synonyms

    1. 14516-56-4

    2. Perazine Maleate

    3. Perazine Maleate [jan]

    4. Perazine Maleate (jan)

    5. 3vg1507988

    6. (z)-but-2-enedioic Acid;10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

    7. Unii-3vg1507988

    8. Chebi:31979

    9. Perazine Dimaleate [who-dd]

    10. D01412

    11. Q27258087

    12. Perazine Dimaleate 1.0 Mg/ml In Dimethyl Sulfoxide (as Free Base)

    13. 10h-phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-, (z)-2-butenedioate (1:2)

    14. Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-, Maleate (1:2)

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 571.6 g/mol
    Molecular Formula C28H33N3O8S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count8
    Exact Mass571.19883619 g/mol
    Monoisotopic Mass571.19883619 g/mol
    Topological Polar Surface Area184 Ų
    Heavy Atom Count40
    Formal Charge0
    Complexity493
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)