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1. Afo 150
2. Imagent
3. Imavist
4. Perfluoro-n-hexane
5. Perfluorohexane
1. Perfluorohexane
2. 355-42-0
3. Tetradecafluorohexane
4. Hexane, Tetradecafluoro-
5. Perfluoro-n-hexane
6. Flutec Pp1
7. Perfluorohexanes
8. N-tetradecafluorohexane
9. N-perfluorohexane
10. Fluorinert Fc72
11. Af0150
12. Perfluoro-compound Fc-72
13. Fluorinert Fc-72
14. 1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluorohexane
15. Fluorinertr(fc-72)
16. Fx3wj41cmx
17. Chebi:39427
18. Perfluorohexane(s)
19. Af-0150
20. Fluorinert(r) Fc-72
21. Ncgc00166122-01
22. Fluorinert(tm) (fc-72)(r)
23. Hexane, 1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluoro-
24. Perflexane [usan:inn]
25. Hexane, 1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluoro-, Homopolymer
26. 25916-42-1
27. Einecs 206-585-0
28. Unii-fx3wj41cmx
29. Per-fluorohexane
30. Imagent?
31. Imavist?
32. Hsdb 7871
33. Fc-72
34. Mfcd00000437
35. Perflexane [usan]
36. Pp 1 (fluorocarbon)
37. Perflexane [inn]
38. N-perfluorohexane Emulsion
39. Perflexane (usan/inn)
40. Perflexane [vandf]
41. Perflexane [mart.]
42. Tetradecafluorohexane, 99%
43. Dsstox_cid_26548
44. Dsstox_rid_81709
45. Perflexane [who-dd]
46. Perflexane-lipid Microspheres
47. Perfluorohexane [mi]
48. Dsstox_gsid_46548
49. Schembl33789
50. Perfluorohexane [inci]
51. Afo145
52. Afo150
53. Chembl1200607
54. Dtxsid7046548
55. Perflexane [orange Book]
56. Fluorinert Fc72fluorinert Fc72
57. Zjijajxflbmlck-uhfffaoysa-
58. Zinc6827705
59. Tox21_112328
60. Akos005258316
61. Af 0150
62. Db09531
63. As-56640
64. Bp-21389
65. Cas-355-42-0
66. Ft-0676292
67. P0839
68. D05437
69. D92023
70. A822857
71. Q3291714
72. W-109529
73. Perfluorohexane A Mixture Of Perfluorinated Hexanes, 95%
74. Tetradecafluorohexane A Mixture Of Perfluorinated Hexanes
75. 1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluorohexane #
76. Tetradecafluorohexane, A Mixture Of Perfluorinated Hexanes, 95%
| Molecular Weight | 338.04 g/mol |
|---|---|
| Molecular Formula | C6F14 |
| XLogP3 | 5.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 3 |
| Exact Mass | 337.9776443 g/mol |
| Monoisotopic Mass | 337.9776443 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 319 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Diagnostic aid (Ultrasound contrast agent).
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1332
Imagent is an IV injected contrast echocardiography agent designed to image the left ventricle after traversing the pulmonary circulation.
PMID:16785016 Kirkton SD et al; Ultrasound in Med & Biol 32 (6): 949-59 (2006)
... Patients with varying degrees of coronary artery stenosis on quantitative angiography underwent high-mechanical-index myocardial contrast echocardiography at 15 Hz to allow measurement of phasic changes in aBV in large intramyocardial vessels using either Definity (group 1; n=22) or Imagent (group 2; n=22) ... A systolic/diastolic aBV signal ratio of >0.34 provided a sensitivity and specificity of 80% and 71%, respectively, for the detection of >75% coronary stenosis in group 1 patients, whereas a ratio of >0.43 provided a sensitivity and specificity of 89% and 74%, respectively, for the detection of >75% stenosis in group 2 patients. Both the presence and severity of a physiologically significant coronary stenosis can be detected at rest by measuring the increase in aBV on myocardial contrast echocardiography that occurs distally to the stenosis without recourse to any form of stress.
PMID:16103241 Wei K et al; Circulation 112 (8): 1154-60 (2005)
... Twelve patients /were examined. with transcranial ultrasound angiography (t USA) via the temporal bone window after an IV bolus injection of a perfluorocarbon-based microbubble contrast agent (Imagent). The aim was to display the intracranial vessel segments of the middle cerebral artery (M1, M2 and M3), the anterior cerebral artery (A1 and A2), the posterior cerebral artery (P1, P2 and P3) and the internal carotid artery (C1/2 and C3/4). t USA is a B-mode phase inversion imaging technique that uses wideband harmonic signals for image generation ... t USA provides detailed anatomical display at native B-mode spatial resolution with fewer artifacts, yielding improved delineation of intracranial vessels that are in the 1- to 2-mm range.
PMID:16085089 Holscher T et al; Ultrasound in Med & Biol 31 (8): 1001-6 (2005)
For more Therapeutic Uses (Complete) data for Perfluoro-n-hexane (16 total), please visit the HSDB record page.
The metabolism and pharmacokinetic characteristics of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124), 1-chloro-1,1-difluoroethane (HCFC-142b), and perfluorohexane (PFH) were studied in rats. The study was part of a program to investigate possible health hazards presented by candidate Halon replacements for use as a fire extinguishant. Male Fischer-344-rats and Sprague-Dawley-rats were exposed nose only to 10,000 parts per million (ppm) HCFC-123, HCFC-124, HCFC-142b, or PFH for 2 hours. Urine samples were collected for 24 hours. The rats were killed 0 or 24 hours after exposure and the tissue distribution of the compounds and their metabolites was determined by gas chromatography and fluorine-19 nuclear magnetic resonance spectroscopy. HCFC-123, HCFC-124, HCFC-142b, and PFH were detected in all tissues of rats killed immediately after exposure. ... Most tissue concentrations of the halocarbons and metabolites were below the detection limit in rats examined 24 hours post exposure. ... No PFH metabolites were detected /in urine/. ...
Dodd DE et al; Toxicology Letters 68 (1/2): 37-47 (1993)
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