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    Perflubron

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 423-55-2, 1-bromoperfluorooctane, Perfluorooctyl bromide, 1-bromoheptadecafluorooctane, Perfluoro-n-octyl bromide, Liquivent
    Molecular Formula
    C8BrF17
    Molecular Weight
    498.96  g/mol
    InChI Key
    WTWWXOGTJWMJHI-UHFFFAOYSA-N
    FDA UNII
    Q1D0Q7R4D9
    Perflubron is a synthetic radiopaque liquid form of perfluorooctyl bromide. Used as a contrast agent for magnetic resonance imaging (MRI), perflubron is also used as a liquid ventilation agent to improve pulmonary gas exchange and lung compliance and may be used in surgery to reduce or eliminate the need for donor blood. Ventilation with perfluorocarbon fluid improves lung function in conditions involving surfactant deficiency and dysfunction, including respiratory distress syndrome and adult respiratory distress syndrome. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
    2.1.2 InChI
    InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26
    2.1.3 InChI Key
    WTWWXOGTJWMJHI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(C(C(C(C(F)(F)Br)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    Q1D0Q7R4D9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Af0144

    2. Imagent Bp

    3. Imagent Gi

    4. L 1913

    5. L-1913

    6. La 11063

    7. La11063

    8. Oxygent

    9. Perflubron Emulsion

    10. Perfluoroctylbromide

    11. Perfluorooctyl Bromide

    12. Perfluorooctyl Iodide

    13. Perfluorooctylbromide

    14. Perfluorooctyliodide

    15. Pfob

    2.3.2 Depositor-Supplied Synonyms

    1. 423-55-2

    2. 1-bromoperfluorooctane

    3. Perfluorooctyl Bromide

    4. 1-bromoheptadecafluorooctane

    5. Perfluoro-n-octyl Bromide

    6. Liquivent

    7. Perfluoroctyl Bromide

    8. Imagent Gi

    9. Perfluorooctylbromide

    10. Pfob

    11. Imagent

    12. 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane

    13. Heptadecafluoro-n-octyl Bromide

    14. Bromoperfluoroctane

    15. N-perfluorooctyl Bromide

    16. Perfluorocaprylyl Bromide

    17. Octane, 1-bromoheptadecafluoro-

    18. Q1d0q7r4d9

    19. Chebi:38803

    20. Octane, 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-

    21. Ncgc00166217-01

    22. Long's Compound

    23. Dsstox_cid_26560

    24. Dsstox_rid_81719

    25. Dsstox_gsid_46560

    26. Cas-423-55-2

    27. Einecs 207-028-4

    28. Unii-q1d0q7r4d9

    29. Perflubron [usan:usp:inn]

    30. Imagent (tn)

    31. Perfluoro-octylbromide

    32. Perflubron [mi]

    33. Perflubron (usp/inn)

    34. Perflubron [inn]

    35. Perflubron [usan]

    36. Pfobperfluorooctyl Bromide

    37. Perflubron [vandf]

    38. Heptadecafluorooctyl Bromide

    39. Bromure De N-perfluorooctyle

    40. Perflubron [mart.]

    41. Perflubron [usp-rs]

    42. Perflubron [who-dd]

    43. Schembl33826

    44. Heptadecafluoro-n-octylbromide

    45. 1-bromo-heptadecafluoro-octane

    46. Chembl1200866

    47. Dtxsid5046560

    48. Perflubron [orange Book]

    49. Cf3-(cf2)6-cf2-br

    50. Perflubron [usp Monograph]

    51. 1-bromoheptadecafluorooctane, 99%

    52. Hy-b1724

    53. Zinc8214650

    54. Tox21_112353

    55. Mfcd00042082

    56. S3501

    57. Akos015833872

    58. Tox21_112353_1

    59. Db05791

    60. Fs-4333

    61. Perfluorocaprylyl Bromide [inci]

    62. Ncgc00166217-02

    63. Db-050901

    64. Cs-0013729

    65. Ft-0607546

    66. H0946

    67. D05439

    68. A825867

    69. Sr-01000944517

    70. Q2190150

    71. Sr-01000944517-1

    72. Perflubron, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 498.96 g/mol
    Molecular Formula C8BrF17
    XLogP36.9
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count17
    Rotatable Bond Count6
    Exact Mass497.89119 g/mol
    Monoisotopic Mass497.89119 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity527
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in cardiac surgery, hemorrhage, and ileus.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Contrast Media

    Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

    Anti-Obesity Agents

    Agents that increase energy expenditure and weight loss by neural and metabolic regulation. (See all compounds classified as Anti-Obesity Agents.)

    Radiation-Sensitizing Agents

    Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells. (See all compounds classified as Radiation-Sensitizing Agents.)

    5.2 ATC Code

    V - Various

    V08 - Contrast media

    V08C - Magnetic resonance imaging contrast media

    V08CX - Other magnetic resonance imaging contrast media

    V08CX01 - Perflubron

    5.3 Mechanism of Action

    Perflubron emulsion (Oxygent) maintains hemodynamic stability during major surgery, thereby potentially reducing or avoiding intraoperative transfusions of donor blood in major surgery.Perflubron emulsion has ability to enable patients to be physiologically stable and safe at lower intraoperative Hb levels.