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1. D 21266
2. D-21266
3. Octadecyl-(1,1-dimethyl-4-piperidylio)phosphate
1. 157716-52-4
2. Krx-0401
3. 1,1-dimethylpiperidin-1-ium-4-yl Octadecyl Phosphate
4. Perifosine (krx-0401)
5. (1,1-dimethylpiperidin-1-ium-4-yl) Octadecyl Phosphate
6. Nsc 639966
7. Perifosine [inn]
8. D 21266
9. Nsc-639966
10. 1,1-dimethylpiperidinium-4-yl Octadecyl Phosphate
11. Krx 0401
12. Nsc639966
13. D-21266
14. Chebi:67272
15. 2gwv496552
16. Ncgc00187909-01
17. Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, Inner Salt
18. 1,1-dimethylpiperidin-1-ium-4-yl Octadecyl Phosphate.
19. Piperidinium, 4-((hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethyl-, Inner Salt
20. Nka17
21. Unii-2gwv496552
22. Octadecyl-(1,1-dimethyl-4-piperidylio)phosphate
23. 4-((hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethylpiperidinium Inner Salt
24. Perifosine [mi]
25. Dsstox_cid_28872
26. Dsstox_rid_83141
27. Perifosine [who-dd]
28. Dsstox_gsid_48946
29. Schembl93872
30. Chembl372764
31. Gtpl7424
32. Dtxsid3048946
33. Bcp00245
34. Ex-a2229
35. Yhi-1003
36. Tox21_113365
37. Bdbm50431630
38. Mfcd00927554
39. Nsc800842
40. S1037
41. Piperidinium,1-dimethyl-, Inner Salt
42. Akos005146344
43. Ccg-269358
44. Cs-0209
45. Db06641
46. Ex-3388
47. Gs-3834
48. Nsc-800842
49. Ncgc00187909-02
50. Ncgc00187909-13
51. Ac-25019
52. Am808092
53. Hy-50909
54. Cas-157716-52-4
55. Ft-0651459
56. P2831
57. A23834
58. D21266
59. Octadecyl-(1,1-dimethyl-4-piperidylio) Phosphate
60. J-500086
61. Q3411917
62. Perifosine; Krx-0401; Nsc 639966; D21266
63. 1,1-dimethylpiperidinium-4-yl Octadecyl Phosphate, Inner Salt
64. 4-hydroxy-1,1-dimethylpiperidinium Hydroxide, Octadecyl Hydrogen Phosphate, Inner Salt
Molecular Weight | 461.7 g/mol |
---|---|
Molecular Formula | C25H52NO4P |
XLogP3 | 8.3 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 4 |
Rotatable Bond Count | 20 |
Exact Mass | 461.36339614 g/mol |
Monoisotopic Mass | 461.36339614 g/mol |
Topological Polar Surface Area | 58.6 Ų |
Heavy Atom Count | 31 |
Formal Charge | 0 |
Complexity | 454 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer.
Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.