1. Anodynin
2. Phenazone
3. Pyramidone
1. Phenazone
2. 60-80-0
3. Phenazon
4. Antipyrin
5. Analgesine
6. Anodynine
7. Anodynin
8. Azophen
9. Fenazone
10. 2,3-dimethyl-1-phenyl-5-pyrazolone
11. Antipirin
12. Antipyrinum
13. Phenozone
14. Apirelina
15. Azophene
16. Methozin
17. Parodyne
18. Phenazonum
19. Phenylone
20. Pyrazophyl
21. Sedatine
22. Sedatin
23. Dimethyloxychinizin
24. Dimethyloxyquinazine
25. Oxydimethylquinazine
26. Azophenum
27. Phenylon
28. 3-antipyrine
29. Fenazon [czech]
30. Fenazona
31. 3h-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-
32. Fenazona [inn-spanish]
33. Phenazone (pharmaceutical)
34. Fenazon
35. 1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one
36. Oxydimethylquinizine
37. 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-one
38. 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
39. 1-phenyl-2,3-dimethyl-5-pyrazolone
40. 1-phenyl-2,3-dimethylpyrazole-5-one
41. Chebi:31225
42. Nsc 7945
43. Phenazone;phenazon
44. 1,5-dimethyl-2-phenylpyrazol-3-one
45. Phenazone [inn]
46. T3cha1b51h
47. Phenazone (inn)
48. Nsc-7945
49. 1,5-dimethyl-2-phenyl-2,3-dihydro-1h-pyrazol-3-one
50. Cas-60-80-0
51. Ncgc00016274-04
52. Dsstox_cid_1117
53. Dsstox_rid_75949
54. Dsstox_gsid_21117
55. Antipyrine [jan]
56. Phenazonum [inn-latin]
57. Smr000238140
58. Ccris 1369
59. Antipyrine [usp:jan]
60. Sr-05000001566
61. Einecs 200-486-6
62. Unii-t3cha1b51h
63. Antipyrien
64. 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-one; Phenazone
65. Ai3-15293
66. .beta.-antipyrine
67. Prestwick_26
68. Antipyrine Crystals
69. Mfcd00003146
70. Component Of Auralgan
71. 1,5-dimethyl-2-phenyl-pyrazol-3-one
72. Spectrum_000058
73. Antipyrine [mi]
74. Prestwick0_000029
75. Prestwick1_000029
76. Prestwick2_000029
77. Prestwick3_000029
78. Spectrum2_000088
79. Spectrum3_000305
80. Spectrum4_000152
81. Spectrum5_000842
82. Antipyrine [vandf]
83. Antipyrinum [hpus]
84. Antipyrine (jp17/usp)
85. Epitope Id:124927
86. Phenazone [mart.]
87. Ec 200-486-6
88. Phenazone [who-dd]
89. 1,5-dimethyl-2-phenyl-1h-pyrazol-3(2h)-one
90. Antipyrine [usp-rs]
91. Schembl20452
92. Bspbio_000097
93. Bspbio_001870
94. Kbiogr_000624
95. Kbioss_000438
96. Mls001331753
97. Mls001332401
98. Mls001332402
99. Mls002154179
100. Divk1c_000484
101. Spectrum1500128
102. Spbio_000016
103. Spbio_002018
104. Antipyrine, Analytical Standard
105. Bpbio1_000107
106. Chembl277474
107. Phenazone [ep Impurity]
108. Dtxsid6021117
109. Phenazone [ep Monograph]
110. Hms501i06
111. Kbio1_000484
112. Kbio2_000438
113. Kbio2_003006
114. Kbio2_005574
115. Kbio3_001370
116. Zinc61044
117. Antipyrine [usp Impurity]
118. Nsc7945
119. Antipyrine, >=99.0% (rt)
120. Ninds_000484
121. Antipyrine [usp Monograph]
122. Hms1568e19
123. Hms1920e09
124. Hms2091k09
125. Hms2095e19
126. Hms2272g04
127. Hms3652c09
128. Hms3712e19
129. Hms3885c11
130. Pharmakon1600-01500128
131. Wln: T5nnvj A1 Br& E1
132. Hy-b0171
133. Tox21_110342
134. Tox21_201600
135. Tox21_303026
136. Antipyrine, Sigma Reference Standard
137. Bdbm50103600
138. Ccg-38904
139. Nsc755874
140. S3173
141. Stk328171
142. 1,5-dimethyl-2-phenyl-3-pyrazolone
143. Phenazone 100 Microg/ml In Methanol
144. Akos000588788
145. Tox21_110342_1
146. Cs-2044
147. Db01435
148. Nsc-755874
149. Idi1_000484
150. Phenazone 10 Microg/ml In Acetonitrile
151. Antipyrine, Analytical Reference Material
152. Antipyrine, Tested According To Ph.eur.
153. Ncgc00016274-01
154. Ncgc00016274-02
155. Ncgc00016274-03
156. Ncgc00016274-05
157. Ncgc00016274-06
158. Ncgc00016274-07
159. Ncgc00016274-09
160. Ncgc00016274-10
161. Ncgc00094591-01
162. Ncgc00094591-02
163. Ncgc00094591-03
164. Ncgc00178937-01
165. Ncgc00178937-02
166. Ncgc00256527-01
167. Ncgc00259149-01
168. As-13248
169. Sbi-0051287.p003
170. Antipyrine, Vetec(tm) Reagent Grade, 98%
171. D1876
172. Ft-0609690
173. Ft-0662246
174. Sw196343-3
175. A19580
176. Bim-0051287.0001
177. D01776
178. H11233
179. Propyphenazone Impurity A [ep Impurity]
180. 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one
181. A936893
182. Af-960/00437050
183. Q415578
184. Q-201552
185. Sr-05000001566-1
186. Sr-05000001566-3
187. Brd-k46937689-001-05-1
188. Brd-k46937689-001-08-5
189. Z56869297
190. 2-trideuteromethyl-3-methyl-1-phenyl-3-pyrazolin-5-one
191. F2173-0728
192. 1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one #
193. Phenazone, European Pharmacopoeia (ep) Reference Standard
194. Antipyrine, United States Pharmacopeia (usp) Reference Standard
| Molecular Weight | 188.23 g/mol |
|---|---|
| Molecular Formula | C11H12N2O |
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 188.094963011 g/mol |
| Monoisotopic Mass | 188.094963011 g/mol |
| Topological Polar Surface Area | 23.6 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 267 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes. In combination with benzocaine in otic solutions, antipyrine is indicated for the symptomatic relief of acute otitis media arising from various etiologies.
Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
N - Nervous system
N02 - Analgesics
N02B - Other analgesics and antipyretics
N02BB - Pyrazolones
N02BB01 - Phenazone
S - Sensory organs
S02 - Otologicals
S02D - Other otologicals
S02DA - Analgesics and anesthetics
S02DA03 - Phenazone
Antipyrine has known human metabolites that include 3-hydroxy-methylantipyrine, 4-hydroxy-antipyrine, and Norantipyrine.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
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