1. 1,4 Diazacyclohexane
2. 1,4 Piperazine
3. 1,4-diazacyclohexane
4. 1,4-piperazine
5. Piperazine
6. Piperazine Diacetate
7. Piperazine Dihydrochloride
8. Piperazine Hexahydrate
9. Piperazine Hydrate
10. Piperazine Hydrobromide
11. Piperazine Hydrochloride
12. Piperazine Phosphate
13. Piperazine Phosphate (1:1)
14. Piperazine Phosphate Anhydrous
15. Piperazine Salt
16. Piperazine Sulfate
17. Piperazine Tartrate
18. Piperazine Tartrate (1:1), (r-(r*,r*))-isomer
19. Piperazine Tartrate, (r-(r*,r*))-isomer
20. Piperazinium Oleate
21. Pripsen
1. Piperazine Hydrochloride
2. 7542-23-6
3. Piperazine, Monohydrochloride
4. Piperazine Hcl
5. 6094-40-2
6. Piperazine;hydrochloride
7. Unii-7n36jha4p6
8. 7n36jha4p6
9. Piperazine Hydrochloride Hydrate
10. Einecs 231-422-5
11. Dtxsid2064739
12. Piperazine, Hydrochloride (1:1)
13. Einecs 228-042-7
14. Purina Liquid Dog Wormer
15. Schembl7690
16. Piperazine Hydrochloride Salt
17. Dtxcid1047782
18. Piperazine Hydrochloric Acid Salt
19. 8006-71-1
20. Db-309178
21. Ns00081249
22. Ns00082816
23. Piperazine Monohydrochloride [green Book]
24. A845331
25. Q27268592
1. Piperazine Hydrochloride
2. Piperazine Dihydrochloride
| Molecular Weight | 122.60 g/mol |
|---|---|
| Molecular Formula | C4H11ClN2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | g/mol |
| Monoisotopic Mass | g/mol |
| Topological Polar Surface Area | 24.1 |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 26.5 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
Antinematodal Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
MEDICATION (VET): HIGHLY EFFECTIVE AS ANTHELMINTIC FOR REMOVAL OF LARGE ROUNDWORMS, ASCARIDS, FROM POULTRY AND SWINE NODULAR WORMS (OESOPHAGOSTOMUM SPP) FROM SWINE, SHEEP AND CATTLE; AND PINWORMS AND SMALL STRONGYLES IN HORSES.
Spencer, E.Y. Guide to the Chemicals Used in Crop Protection. 6th ed. Publication 1093, Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1973., p. 416
CLINICALLY, THE DRUG IS HIGHLY EFFECTIVE AGAINST BOTH ASCARIS LUMBRICOIDES & ENTEROBIUS (OXYURIS) VERMICULARIS. A LARGE NUMBER OF SUBSTITUTED PIPERAZINE DERIVATIVES EXHIBIT ANTIHELMINTIC ACTIVITY, BUT APART FROM DIETHYLCARBAMAZINE NONE HAS FOUND A PLACE IN HUMAN THERAPEUTICS.
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 966
PIPERAZINE PREPN ARE ALWAYS GIVEN ORALLY. PRIOR FASTING OR SUMPPLEMENTARY TREATMENT WITH CATHARTICS OR ENEMAS IS UNECESSARY.
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 967
For more Therapeutic Uses (Complete) data for PIPERAZINE HYDROCHLORIDE (9 total), please visit the HSDB record page.
VET: VAPORS & SKIN OR EYE CONTACT WITH CONCN MATERIAL MUST BE AVOIDED.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 460
Adequate and well-controlled studies in humans have not been done. Piperazine has been used without apparent adverse effects during pregnancy. In three cases of first trimester exposures to piperazine by pregnant women, no malformations were seen in the fetuses. However, because a study showed that orally administered piperazine undergoes partial conversion to a potentially carcinogenic nitrosamine derivative, it is recommended that piperazine be given to pregnant women only if clearly indicated and then only if alternative drugs are not available.
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 2960
PIPERAZINE IS CONTRAINDICATED IN PATIENTS A WITH HISTORY OF EPILEPSY. NEUROTOXIC EFFECTS HAVE OCCURRED IN INDIVIDUALS WITH RENAL DYSFUNCTION BECAUSE URINARY EXCRETION IS MAIN ROUTE OF ELIMINATION OF THE DRUG.
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 967
There has been a report of cross-reactivity between piperazine and ethylenediamine, a substance used as a stabilizer in topical creams. Piperazine can cause a contact allergy that could be life-threatening in a person who has been sensitized to ethylenediamine either by topical application or by occupational exposure. Although rare, adverse dermatologic problems also may occur due to the cross-sensitivity of these two medications.
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 2960
It is contraindicated in patients with renal or hepatic insufficiency or epilepsy. /Piperazine citrate/
American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 1754
2= SLIGHTLY TOXIC; PROBABLE ORAL LETHAL DOSE (HUMAN) 5-15 G/KG, BETWEEN 1 PINT & 1 QT FOR 70 KG PERSON (150 LB).
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-390
Antinematodal Agents
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)
NOT ABSORBED THROUGH SKIN IN ACUTE TOXIC AMT.
Spencer, E.Y. Guide to the Chemicals Used in Crop Protection. 6th ed. Publication 1093, Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1973., p. 416
PIPERAZINE IS PARTLY METABOLIZED IN AN UNKNOWN MANNER IN MAN, SINCE ONLY 15% OF 2 G DOSES ARE EXCRETED UNCHANGED. /PIPERAZINE/
WILLIAMS RT; 2ND ED, CHAPMAN AND HALL, 614 (1959)
ANTHELMINTIC ACTION IS BY NARCOTIZING AND IMMOBILIZING INTERNAL PARASITES.
Spencer, E.Y. Guide to the Chemicals Used in Crop Protection. 6th ed. Publication 1093, Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1973., p. 416
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