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    Technical details about Polypropylene Glycol, learn more about the structure, uses, toxicity, action, side effects and more

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    Polypropylene Glycol

    DEVELOPMENTS

    PRICE INFORMATION

    PharmaCompass

    Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    2D Structure
    1. Also known as: 2-(2-hydroxypropoxy)-1-propanol, 106-62-7, 25322-69-4, 1-propanol, 2-(2-hydroxypropoxy)-, Polyoxypropylene glycol, 2-(2-hydroxypropoxy)propanol
    Molecular Formula
    C6H14O3
    Molecular Weight
    134.17  g/mol
    InChI Key
    DUFKCOQISQKSAV-UHFFFAOYSA-N
    FDA UNII
    WNY0H4G53Q
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(2-hydroxypropoxy)propan-1-ol
    2.1.2 InChI
    InChI=1S/C6H14O3/c1-5(8)4-9-6(2)3-7/h5-8H,3-4H2,1-2H3
    2.1.3 InChI Key
    DUFKCOQISQKSAV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CO)OCC(C)O
    2.2 Other Identifiers
    2.2.1 UNII
    WNY0H4G53Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(2-hydroxypropoxy)-1-propanol

    2.3.2 Depositor-Supplied Synonyms

    1. 2-(2-hydroxypropoxy)-1-propanol

    2. 106-62-7

    3. 25322-69-4

    4. 1-propanol, 2-(2-hydroxypropoxy)-

    5. Polyoxypropylene Glycol

    6. 2-(2-hydroxypropoxy)propanol

    7. Methyloxirane Homopolymer

    8. Alpha-hydro-omega-hydroxypoly(oxypropylene)

    9. Polypropylene Glycol (m W 1,200-3,000)

    10. Wny0h4g53q

    11. Polyoxypropylene

    12. Emkapyl

    13. Lineartop E

    14. Niax Ppg

    15. Desmophen 360c

    16. Polyglycol P 400

    17. Niax Ppg 425

    18. Jeffox Ppg 400

    19. Polyglycol P-2000

    20. Polyglycol P-4000

    21. Voranol P 1010

    22. Laprol 2002

    23. Niax Ppg 1025

    24. Niax Ppg 3025

    25. Polyglycol Type P250

    26. Polyglycol Type P400

    27. Polyglycol Type P750

    28. Napter E 8075

    29. Niax Polyol Ppg 4025

    30. Polyglycol Type P1200

    31. Polyglycol Type P2000

    32. Polyglycol Type P3000

    33. Propylene Oxide Homopolymer

    34. Laprol 702

    35. Poly(propylene Glycol)

    36. Unii-wny0h4g53q

    37. Propylene Oxide, Propylene Glycol Polymer

    38. Polypropylene Oxide

    39. Poly(propylene Glycol) Macromolecule

    40. Einecs 203-416-2

    41. Poly Propylene Glycol

    42. Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl))

    43. Ppg?

    44. Schembl15111

    45. Chebi:53262

    46. Dtxsid30861722

    47. 2-methyl-3-oxahexane-1,5-diol

    48. Chebi:179442

    49. Akos015899603

    50. Bs-23535

    51. Ft-0696553

    52. F71159

    53. 106h627

    54. Alpha-hydro-omega-hydroxypoly[oxy(1-methylethylene)]

    55. Q26863457

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 134.17 g/mol
    Molecular Formula C6H14O3
    XLogP3-0.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass134.094294304 g/mol
    Monoisotopic Mass134.094294304 g/mol
    Topological Polar Surface Area49.7 Ų
    Heavy Atom Count9
    Formal Charge0
    Complexity65.3
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Minimum/Potential Fatal Human Dose

    3. 3 = moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint (or 1 lb) for 70 kg person (150 lb).

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-120

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Lower mol wt /PPG's (200-1200) ... are absorbed through the skin to some extent, /but/ skin penetration ... not ... serious industrial hazard ... These ... are not like low mol wt polyethylene glycols in their physiologic activity; they are rapidly absorbed from the GI tract ...

    Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1523

    Acute skin absorption tests ... have indicated that the materials are all poorly absorbed through the skin.

    Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1525

    /Male rats maintained for 100 days on diet containing 1.0% of P750/ ... postulated that material is readily metabolized or eliminated when absorbed in small doses; this probably accounts for its lack of apparent physiological effect.

    Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1525

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