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    Technical details about Poseltinib, learn more about the structure, uses, toxicity, action, side effects and more

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    Poseltinib

    DEVELOPMENTS

    PharmaCompass

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    2D Structure
    1. Also known as: 1353552-97-2, Poseltinib [inn], Hm71224, Ly3337641, D01e4b1u35, Poseltinib (hm-71224; ly-3337641)
    Molecular Formula
    C26H26N6O3
    Molecular Weight
    470.5  g/mol
    InChI Key
    LZMJNVRJMFMYQS-UHFFFAOYSA-N
    FDA UNII
    D01E4B1U35
    Poseltinib is an inhibitor of Bruton's tyrosine kinase (BTK) with potential anti-inflammatory activity. Upon administration, poseltinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents the activation of BTK-mediated inflammatory pathways.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
    2.1.2 InChI
    InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)
    2.1.3 InChI Key
    LZMJNVRJMFMYQS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)OC=C4
    2.2 Other Identifiers
    2.2.1 UNII
    D01E4B1U35
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. N-(3-(2-(4-(4-methylpiperazin-1-yl)anilino)furo(3,2-d)pyrimidin-4-yl)oxyphenyl)prop-2-enamide

    2.3.2 Depositor-Supplied Synonyms

    1. 1353552-97-2

    2. Poseltinib [inn]

    3. Hm71224

    4. Ly3337641

    5. D01e4b1u35

    6. Poseltinib (hm-71224; Ly-3337641)

    7. N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

    8. 2-propenamide, N-(3-((2-((4-(4-methyl-1-piperazinyl)phenyl)amino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-

    9. N-(3-((2-(4-(4-methylpiperazin-1-yl)anilino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)prop-2-enamide

    10. Unii-d01e4b1u35

    11. Gtpl9862

    12. Chembl4163691

    13. Schembl14915064

    14. Dtxsid501112972

    15. Bdbm50369724

    16. Bs-15248

    17. Hm-71224

    18. Ly333764

    19. Example 228 [wo2011162515a2]

    20. Hy-109010

    21. Cs-0030508

    22. Hm71224; Ly3337641

    23. D71176

    24. Q27275916

    2.4 Create Date
    2012-03-02
    3 Chemical and Physical Properties
    Molecular Weight 470.5 g/mol
    Molecular Formula C26H26N6O3
    XLogP34.1
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count7
    Exact Mass470.20663871 g/mol
    Monoisotopic Mass470.20663871 g/mol
    Topological Polar Surface Area95.8 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity709
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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