1. Dipotassium Hydrogen Phosphate
2. K2hpo4
3. Kd2po4
4. Potassium Acid Phosphate
5. Potassium Dideuterium Phosphate
6. Potassium Monohydrogen Phosphate
7. Potassium Phosphate
8. Potassium Phosphate (k-h2po4)
9. Potassium Phosphate (k-h3po4(1:2))
10. Potassium Phosphate (k2-hpo4)
11. Potassium Phosphate (k3-po4)
12. Potassium Phosphate, Dibasic
13. Potassium Phosphate, Monobasic
14. Potassium Phosphate, Unspecified Form
1. 7778-77-0
2. Potassium Phosphate Monobasic
3. Monopotassium Phosphate
4. Monobasic Potassium Phosphate
5. Potassium Acid Phosphate
6. Potassium Phosphate, Monobasic
7. Monopotassiumphosphate
8. Phosphoric Acid, Monopotassium Salt
9. Potassium Dihydrogen Orthophosphate
10. Monopotassium Monophosphate
11. Monopotassium Orthophosphate
12. Monopotassium Dihydrogen Phosphate
13. Potassium Dihydrogenorthophosphate
14. Potassium Biphosphate
15. Potassium Dihydrogenphosphate
16. Potassium;dihydrogen Phosphate
17. Sorensen's Potassium Phosphate
18. Potassium Phosphate (k(h2po4))
19. Kh2po4
20. Orthophosphoric Acid, Monopotassium Salt
21. Chebi:63036
22. Mfcd00011401
23. 4j9fj0hl51
24. Mkp
25. Monopotassium Dihydrogen Monophosphate
26. Monopotassium Dihydrogen Orthophosphate
27. Phosphoric Acid, Potassium Salt (1:1)
28. Potassium Phosphate Monobasic (anhydrous)
29. Chlorine Titrimeter Reagent
30. Buffer Solution, Ph 6.00
31. Buffer Solution, Ph 7.00
32. Buffer Solution, Ph 7.40
33. Mfcd00147253
34. Potassium Dihydrogen Orthophosphate(v)
35. Hsdb 5046
36. Buffer Solution, Ph 7.00, Color-coded Yellow
37. Potassium Orthophosphate, Dihydrogen
38. Einecs 231-913-4
39. Epa Pesticide Chemical Code 076413
40. Potassium Hydrogen Phosphate (kh2po4)
41. Unii-4j9fj0hl51
42. Potassium Phosphate, Monobasic [nf]
43. Mono Potassium Phosphate
44. Mono-potassium Phosphate
45. Ec 231-913-4
46. Potassium Phosphate,monobasic
47. Potassium Di-hydrogen Phosphate
48. Chembl1200925
49. Dtxsid0035667
50. Ins No.340(i)
51. Unii-b7862wz632
52. Ins-340(i)
53. Potassium Phosphate [inci]
54. Potassium Dihydrogen Phosphate,(s)
55. Einecs 240-213-8
56. Bdbm50004328
57. Akos015902364
58. Akos028109678
59. B7862wz632
60. Db09413
61. Phosphoric Acid, Potassium Salt (1:?)
62. Potassium Phosphate, Monobasic (jan/nf)
63. E-340(i)
64. Potassium Dihydrogen Phosphate, Puratronic?
65. Potassium Phosphate, Monobasic [ii]
66. Potassium Phosphate, Monobasic [mi]
67. B7291
68. Ft-0645117
69. Monobasic Potassium Phosphate [mart.]
70. Potassium Phosphate, Monobasic [fcc]
71. Potassium Phosphate, Monobasic [hsdb]
72. Potassium Phosphate, Monobasic [jan]
73. Potassium Phosphate,monobasic [vandf]
74. Monobasic Potassium Phosphate [usp-rs]
75. Potassium Phosphate Monobasic [who-dd]
76. D02050
77. Potassium Phosphate Monobasic, Trace Metals Grade
78. Q415049
79. Potassium Dihydrogen Phosphate [ep Monograph]
80. Potassium Phosphate, 0.2m Buffer Solution, Ph 7.0
81. Potassium Phosphate, 0.2m Buffer Solution, Ph 7.2
82. Potassium Phosphate, 0.2m Buffer Solution, Ph 7.4
83. Potassium Phosphate, 0.2m Buffer Solution, Ph 7.5
84. Potassium Phosphate, 0.2m Buffer Solution, Ph 7.6
85. Potassium Phosphate, 0.5m Buffer Solution, Ph 7.0
86. Potassium Phosphate, 0.5m Buffer Solution, Ph 7.4
87. Potassium Phosphate, 0.5m Buffer Solution, Ph 7.5
88. Potassium Phosphate, 0.5m Buffer Solution, Ph 7.6
89. Potassium Phosphate, Monobasic [orange Book]
90. Tis-u-sol Component Potassium Phosphate, Monobasic
91. Potassium Phosphate Monobasic Powder Suitable For Cell Culture
92. Potassium Phosphate, Monobasic Component Of Tis-u-sol
93. Potassium Phosphates Component Monobasic Potassium Phosphate
94. Monobasic Potassium Phosphate Component Of Potassium Phosphates
95. Buffer Solution, Ph 1.68 (+/-0.01 At 25?c), No Color, Specpure, Nist Traceable
| Molecular Weight | 136.086 g/mol |
|---|---|
| Molecular Formula | H2KO4P |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 0 |
| Exact Mass | 135.93277702 g/mol |
| Monoisotopic Mass | 135.93277702 g/mol |
| Topological Polar Surface Area | 80.6 Ų |
| Heavy Atom Count | 6 |
| Formal Charge | 0 |
| Complexity | 61.9 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
The solution is intended to provide phosphate ion, (PO4-3) for addition to large volume infusion fluids for intravenous use. Potassium Phosphates Injection, USP, 3 mM P/mL, is indicated as a source of phosphorus, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. The concomitant amount of potassium (4.4 mEq/mL) must be calculated into total electrolyte content of such prepared solutions.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
Urinary acidification by potassium and sodium phosphates combination and monobasic potassium phosphate augments the efficacy of methenamine mandelate and methenamine hippurate, which are dependent upon an acid medium for antibacterial activity. Phosphates eliminate the odor, rash, and turbidity present with ammoniacal urine associated with urinary tract infections. However, use of phosphates for urea splitting urinary tract infections may predispose to struvite stones that form in alkaline urine. /Included in US product labeling/
Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 2453
Potassium and sodium phosphates combination and monobasic potassium phosphate have been used to reduce urinary calcium concentration and help prevent precipitation of calcium deposits in the urinary tract. /Included in US product labeling/
Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 2453
At the renal distal tubule, the secretion of hydrogen by the tubular cell in exchange for sodium in the tubular urine converts dibasic phosphate salts to monobasic phosphate salts. Therefore, large amounts of acid can be excreted without lowering the pH of the urine to a degree that would block hydrogen transport by a high concentration gradient between the tubular cell and luminal fluid. /Phosphates/
Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 2453
For more Therapeutic Uses (Complete) data for MONOPOTASSIUM DIHYDROGEN PHOSPHATE (7 total), please visit the HSDB record page.
Potassium Phosphates Injection is contraindicated in diseases where high potassium, high phosphorus or low calcium levels may be encountered.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
Hypophosphatemia should be avoided during periods of total parenteral nutrition, or other lengthy periods of intravenous infusions. Serum phosphorus levels should be regularly monitored, and appropriate amounts of phosphorus should be added to the infusions to maintain normal serum phosphorus levels. Intravenous infusion of inorganic phosphorus may be accompanied by a decrease in the serum level and urinary excretion of calcium. The normal level of serum inorganic phosphorus is 3.0 to 4.5 mg/dL in adults and 4.0 to 7.0 mg/dL in children.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
To avoid potassium or phosphorus intoxication, infuse solutions containing potassium phosphates slowly. In patients with severe renal or adrenal insufficiency, administration of Potassium Phosphates Injection may cause potassium intoxication. Infusing high concentrations of phosphorus may cause hypocalcemia, and calcium levels should be monitored.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
Solutions which contain potassium ions should be used with great care if at all, in patients with hyperkalemia, severe renal failure and in conditions in which potassium retention is present.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
For more Drug Warnings (Complete) data for MONOPOTASSIUM DIHYDROGEN PHOSPHATE (16 total), please visit the HSDB record page.
Used in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;
Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Potassium is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism. Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.
Buffers
A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)
Cariostatic Agents
Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed) (See all compounds classified as Cariostatic Agents.)
Absorption
Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.
Route of Elimination
Renal (90%) and fecal (10%) Phosphates Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.
Volume of Distribution
Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells.
Clearance
Phosphates are rapidly cleared by dialysis. Dialysis can also be used to treat other electrolyte abnormalities such as hypernatremia, hypocalcemia, and hypomagnesemia.
Intravenously infused phosphorus not taken up by the tissues is excreted almost entirely in the urine.
US Natl Inst Health; DailyMed. Current Medication Information for POTASSIUM PHOSPHATES (potassium phosphate, monobasic and potassium phosphate, dibasic) injection, solution (Februrary 2011). Available from, as of August 5, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50936b86-2879-4b88-8b15-895afa82e6bf
Potassium salts are well absorbed from the GI tract. ... Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells. In healthy adults, plasma potassium concentrations generally range from 3.5-5 mEq/L. Plasma concentrations up to 7.7 mEq/L may be normal in neonates. ... Potassium is excreted mainly by the kidneys. The cation is filtered by the glomeruli, reabsorbed in the proximal tubule, and secreted in the distal tubule, the site of sodium-potassium exchange. Tubular secretion of potassium is also influenced by chloride ion concentration, hydrogen ion exchange, acid-base equilibrium, and adrenal hormones. Healthy patients on potassium-free diets usually excrete 40-50 mEq of potassium daily. ... Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed. /Potassium Supplements/
American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011
More than 90% of plasma phosphate is freely filtered at the glomerulus, and 80% is actively reabsorbed, predominatly in the initial segment of the proximal convoluted tubule but also in th e proximal straight tubule (pars recta). ... Parathyroid hormone (PTH) increases urinary phosphate excretion by blocking phosphate absorption. Expansion of plasma volume increases urinary phosphate excretion. /Phosphate/
Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 1649
Transport of phosphate from the intestinal lumen is an active, energy-dependent process ... In adults, about two-thirds of the ingested phosphate is absorbed and is excreted almost entirely into the urine. In growing children, phosphate balance is positive, and plasma concentrations of phosphate in plasma are higher in children than in adults. /Phosphates/
Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 1649
For more Absorption, Distribution and Excretion (Complete) data for MONOPOTASSIUM DIHYDROGEN PHOSPHATE (6 total), please visit the HSDB record page.
In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.
hosphorus has a number of important functions in the biochemistry of the body. The bulk of the body's phosphorus is located in the bones, where it plays a key role in osteoblastic and osteoclastic activities. Enzymatically catalyzed phosphate-transfer reactions are numerous and vital in the metabolism of carbohydrate, lipid and protein, and a proper concentration of the anion is of primary importance in assuring an orderly biochemical sequence. ln addition, phosphorus plays an important role in modifying steady-state tissue concentrations of calcium. Phosphate ions are important buffers of the intracellular fluid, and also play a primary role in the renal excretion of the hydrogen ion. Oral administration of inorganic phosphates increases serum phosphate levels. Phosphates lower urinary calcium levels in idiopathic hypercalciuria.
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