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2D Structure
Also known as: 125-04-2, A-hydrocort, Hydrocortisone 21-hemisuccinate sodium salt, Cortop, Solu-cortef, Arcocort
Molecular Formula
C25H33NaO8
Molecular Weight
484.5  g/mol
InChI Key
HHZQLQREDATOBM-CODXZCKSSA-M
FDA UNII
50LQB69S1Z

Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
2.1.2 InChI
InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
2.1.3 InChI Key
HHZQLQREDATOBM-CODXZCKSSA-M
2.1.4 Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
2.1.5 Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
2.2 Other Identifiers
2.2.1 UNII
50LQB69S1Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. A-hyrocort

2. Cortisol Hemisuccinate

3. Cortisol Succinate

4. Cortisol Succinate, Sodium Salt

5. Cortisol-21-(hydrogen Succinate)

6. Hydrocortisone 21-sodium Succinate

7. Hydrocortisone Hemisuccinate

8. Hydrocortisone Hemisuccinate Anhydrous

9. Hydrocortisone Succinate

10. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-

11. Solu-cortef

12. Sopolcort H

13. Sopolkort

2.3.2 Depositor-Supplied Synonyms

1. 125-04-2

2. A-hydrocort

3. Hydrocortisone 21-hemisuccinate Sodium Salt

4. Cortop

5. Solu-cortef

6. Arcocort

7. Buccalsone

8. Corlan

9. Emi-corlin

10. Cortisol 21-(sodium Succinate)

11. Flebocortid

12. Hycorace

13. Intracort

14. Nordicort

15. Oralsone

16. Solu-hizon

17. Solu-glyc

18. Hydrocortisone 21-sodium Succinate

19. Ef-cortelan Soluble

20. 50lqb69s1z

21. Chebi:5782

22. Cortisol Sodium Succinate

23. Hydrocortisone Hemisuccinate

24. Cortisol Sodium Hemisuccinate

25. Sodium Hydrocortisone Succinate

26. Cortisol Hemisuccinate Sodium Salt

27. Hydrocortisone Sodium Hemisuccinate

28. Hydrocortisone 21-sodium Succinide

29. Sodium Hydrocortisone 21-succinate

30. Nsc-9152

31. Hydrocortisone 21-hemisuccinate Sodium

32. Hydrocortisone Sodium 21-hemisuccinate

33. Sodium Hydrocortisone 21-hemisuccinate

34. Hydrocortisone Hemisuccinate Sodium Salt

35. Dsstox_cid_28932

36. Dsstox_rid_83198

37. Dsstox_gsid_49006

38. Hydrocortisone 21-succinate Sodium Salt

39. Sodium 17-hydroxycorticosterone 21-succinate

40. Hidrokortizon

41. U 4905

42. Nositrol

43. Rapicort

44. Lycortin-s

45. Cas-125-04-2

46. Sodium;4-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate

47. Flebocortid [inj.]

48. Hydro-adreson Aquosum

49. Ncgc00022248-03

50. Idrocortisone B. I. L.

51. Unii-50lqb69s1z

52. Hydrocortisone Succinate,sodium Salt

53. Einecs 204-725-5

54. A-hydrocort (tn)

55. Solu-cortef (tn)

56. Hydrocortisone 21-(sodium Succinate)

57. Mfcd00069472

58. Hydrocortisone-21-hemisuccinate Sodium

59. Hydrocortisone-21-hemisuccinate Sodium Salt

60. Cortisol 21-hemisuccinate Sodium Salt

61. Hydrocortisone Sodium Succinate [usp:ban:jan]

62. Schembl93508

63. Hydrocortisoni Natrii Succinas

64. Mls000069545

65. Chembl1200495

66. Dtxsid2049006

67. Cortisol 21-hemisuccinate Sodium

68. Hms2234h22

69. Succinic Acid Hydrocortisone Sodium

70. Tox21_113501

71. Akos024386298

72. Tox21_113501_1

73. Cortisol, Succinate, Sodium Salt

74. Ncgc00022248-04

75. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11.beta.)-

76. Smr000058768

77. Eu-0100623

78. Hydrocortisone Sodium Succinate (jp17/usp)

79. Hydrocortisone Sodium Succinate [jan]

80. U4905

81. C08178

82. D00978

83. F20569

84. H 2270

85. Hydrocortisone Sodium Succinate [mart.]

86. Hydrocortisone Sodium Succinate [vandf]

87. Hydrocortisone 21-sodium Succinate [mi]

88. Hydrocortisone Sodium Succinate [who-dd]

89. Hydrocortisone Sodium Succinate [who-ip]

90. Cortisol, 21-(hydrogen Succinate), Monosodium Salt

91. Hydrocortisone Sodium Succinate [orange Book]

92. Hydrocortisone Sodium Succinate [usp Monograph]

93. Hydrocortisoni Natrii Succinas [who-ip Latin]

94. Q27106890

95. Hydrocortisone 21-hemisuccinate Sodium Salt, >=90% (hplc)

96. Hydrocortisone 21-hemisuccinate Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

97. (11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxypregn-14-ene-3,20-dione, Monosodium Salt

98. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11beta)-

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 484.5 g/mol
Molecular Formula C25H33NaO8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass484.20731229 g/mol
Monoisotopic Mass484.20731229 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count34
Formal Charge0
Complexity915
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameA-hydrocort
PubMed HealthHydrocortisone (Injection)
Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
Active IngredientHydrocortisone sodium succinate
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/vial
Market StatusPrescription
CompanyHospira

2 of 4  
Drug NameSolu-cortef
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Drug LabelSOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
Active IngredientHydrocortisone sodium succinate
Dosage FormInjectable
RouteInjection
Strengtheq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
Market StatusPrescription
CompanyPharmacia And Upjohn

3 of 4  
Drug NameA-hydrocort
PubMed HealthHydrocortisone (Injection)
Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
Active IngredientHydrocortisone sodium succinate
Dosage FormInjectable
RouteInjection
Strengtheq 100mg base/vial
Market StatusPrescription
CompanyHospira

4 of 4  
Drug NameSolu-cortef
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Drug LabelSOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
Active IngredientHydrocortisone sodium succinate
Dosage FormInjectable
RouteInjection
Strengtheq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
Market StatusPrescription
CompanyPharmacia And Upjohn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]