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    Procyclidine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 288Xls

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    2D Structure
    Also known as: 1508-76-5, Kemadrin, Procyclidine hcl, Procyclidine (hydrochloride), Tricyclamol hydrochloride, (r)-tricylamol iodide
    Molecular Formula
    C19H30ClNO
    Molecular Weight
    323.9  g/mol
    InChI Key
    ZFSPFXJSEHCTTR-UHFFFAOYSA-N
    FDA UNII
    CQC932Z7YW
    A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
    2.1.3 InChI Key
    ZFSPFXJSEHCTTR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    CQC932Z7YW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Arpicolin

    2. Hydrochloride, Procyclidine

    3. Kemadren

    4. Kemadrin

    5. Mucinil

    6. Osnervan

    7. Procyclid

    8. Procyclidine

    9. Tricyclamol

    2.3.2 Depositor-Supplied Synonyms

    1. 1508-76-5

    2. Kemadrin

    3. Procyclidine Hcl

    4. Procyclidine (hydrochloride)

    5. Tricyclamol Hydrochloride

    6. (r)-tricylamol Iodide

    7. (+-)-procyclidine Hydrochloride

    8. 30953-84-5

    9. Nsc-757293

    10. 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride

    11. Cqc932z7yw

    12. Mls000028556

    13. 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride

    14. (+/-)-procyclidine Hydrochlorid

    15. Procyclidine Hydrochloride [usp]

    16. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride (1:1)

    17. Smr000058821

    18. 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Hydrochloride

    19. Dsstox_cid_25357

    20. Dsstox_rid_80823

    21. Dsstox_gsid_45357

    22. Procyclidine Hydrochloride (usp)

    23. Chebi:8449

    24. Einecs 216-141-8

    25. Alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanol Hydrochloride

    26. Unii-cqc932z7yw

    27. Sr-01000000095

    28. Kemadrin (tn)

    29. Prestwick_125

    30. Opera_id_270

    31. Ncgc00016585-01

    32. Cas-1508-76-5

    33. Chembl1761

    34. Mls001076129

    35. Mls002222170

    36. Schembl121684

    37. Spectrum1500507

    38. Dtxsid8045357

    39. Regid_for_cid_207841

    40. Hms1570j09

    41. Hms1920l10

    42. Pharmakon1600-01500507

    43. Hy-b1487

    44. Tox21_110508

    45. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride

    46. Ccg-39236

    47. Mfcd00079236

    48. Nsc757293

    49. 1-pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, Hydrochloride

    50. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Monohydrochloride

    51. Tox21_110508_1

    52. Cs-5893

    53. Nc00585

    54. Nsc 757293

    55. Procyclidine Hydrochloride [mi]

    56. Ncgc00018186-07

    57. Ncgc00094769-01

    58. Ncgc00094769-02

    59. Ncgc00094769-03

    60. Ncgc00094769-04

    61. Bs-42188

    62. Procyclidine Hydrochloride [mart.]

    63. Procyclidine Hydrochloride [vandf]

    64. Procyclidine Hydrochloride [usp-rs]

    65. Procyclidine Hydrochloride [who-dd]

    66. Ft-0674043

    67. Sw196436-3

    68. D00782

    69. Procyclidine Hydrochloride [orange Book]

    70. 508p765

    71. Procyclidine Hydrochloride [usp Monograph]

    72. J-008753

    73. Sr-01000000095-4

    74. 5-isopropyl-3-methylisoxazole-4-carboxylicacid

    75. Q27108083

    76. ( Inverted Exclamation Marka)-procyclidine Hydrochlorid

    77. ( Inverted Exclamation Marka)-procyclidine Hydrochloride

    78. (r)-1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Hydrochloride

    79. .alpha.-cyclohexyl-.alpha.-phenyl-1-pyrrolidinepropanol Hydrochloride

    80. Procyclidine Hydrochloride (1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride)

    81. Procyclidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 323.9 g/mol
    Molecular Formula C19H30ClNO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass323.2015923 g/mol
    Monoisotopic Mass323.2015923 g/mol
    Topological Polar Surface Area23.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity301
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)