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    Profenamine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Profenamine hydrochloride, 1094-08-2, Ethopropazine hcl, Lysivane, Pardisol, Parfezin
    Molecular Formula
    C19H25ClN2S
    Molecular Weight
    348.9  g/mol
    InChI Key
    VXPCQISYVPFYRK-UHFFFAOYSA-N
    FDA UNII
    O00T1I1VRN
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
    2.1.3 InChI Key
    VXPCQISYVPFYRK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    O00T1I1VRN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ethopropazine

    2. Lysivane

    3. Parsidol

    4. Parsitan

    5. Profenamine

    6. Profenamine Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. Profenamine Hydrochloride

    2. 1094-08-2

    3. Ethopropazine Hcl

    4. Lysivane

    5. Pardisol

    6. Parfezin

    7. Parphezein

    8. Dibutil

    9. Profenamine Hcl

    10. Profenamine Monohydrochloride

    11. Isothazine Hydrochloride

    12. 10-(2-(diethylamino)propyl)phenothiazine Monohydrochloride

    13. Parsidol Hydrochloride

    14. Parsidol Monohydrochloride

    15. Nsc-64074

    16. Nsc-169467

    17. O00t1i1vrn

    18. Ethopropazine (hydrochloride)

    19. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Monohydrochloride

    20. Ethopropazine Monohydrochloride

    21. Chembl1200970

    22. Chebi:31568

    23. N,n-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride

    24. 42957-54-0

    25. Parphezin

    26. N,n-diethyl-1-(10h-phenothiazin-10-yl)propan-2-amine Hydrochloride

    27. Dsstox_cid_25347

    28. Dsstox_rid_80815

    29. Dsstox_gsid_45347

    30. Parsidol (van)

    31. Lysivane Hydrochloride

    32. 10-(2-(diethylamino)propyl)-phenothiazin Hydrochloride

    33. Profenamine Hydrochloride (jan)

    34. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Hydrochloride

    35. Profenamine Hydrochloride [jan]

    36. Einecs 214-134-4

    37. Nsc 64074

    38. Unii-o00t1i1vrn

    39. Nsc 169467

    40. Sr-05000001626

    41. Prophenamine Hydrochloride

    42. 10h-phenothiazine-10-ethanamine,n-diethyl-.alpha.-methyl-, Monohydrochloride

    43. Ethopropazine Hydrochloride [usp]

    44. Parsidol (tn)

    45. Prestwick_195

    46. Einecs 256-019-1

    47. L-10-(2-diethylaminopropyl)phenothiazine Hydrochloride

    48. Ncgc00016562-01

    49. 10-phenothiazineethylamine, N,n-diethyl-alpha-methyl-, Hydrochloride

    50. Cas-1094-08-2

    51. Schembl123703

    52. Spectrum1500293

    53. Dtxsid4045347

    54. Hms1570h21

    55. Hms1920o04

    56. Pharmakon1600-01500293

    57. Bcp12225

    58. Nsc64074

    59. Phenothiazine, 10-(2-(diethylamino)propyl)-, Monohydrochloride

    60. Tox21_110496

    61. Tox21_500873

    62. Ccg-40202

    63. Nsc169467

    64. Nsc757029

    65. 10h-phenothiazine-10-ethanamine, N,n-diethyl-alpha-methyl-, Monohydrochloride

    66. Akos015901042

    67. Tox21_110496_1

    68. Lp00873

    69. Nsc-757029

    70. Ethopropazine Hydrochloride [mi]

    71. Ncgc00094678-01

    72. Ncgc00094678-02

    73. Ncgc00178860-06

    74. Ncgc00261558-01

    75. Profenamine Hydrochloride [mart.]

    76. Profenamine Hydrochloride [who-dd]

    77. Ethopropazine Hydrochloride [vandf]

    78. Db-040867

    79. Hy-107922

    80. Cs-0030870

    81. Ft-0625740

    82. D01118

    83. Ethopropazine Hydrochloride [orange Book]

    84. Ethopropazine Hydrochloride, >=98% (hplc), Powder

    85. Sr-05000001626-2

    86. Q27114444

    87. 10h-phenothiazine-10-ethanamine,n,n-diethyl-a-methyl-,hydrochloride(1:1)

    88. 10h-phenothiazine-10-ethanamine, N,n-diethyl-.alpha.-methyl-, Hydrochloride (1:1)

    89. Ethopropazine Hydrochloride;profenamine Hcl; Ethopropazine Hcl; 10-[2-diethylaminopropyl]phenothiazine

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 348.9 g/mol
    Molecular Formula C19H25ClN2S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass348.1426977 g/mol
    Monoisotopic Mass348.1426977 g/mol
    Topological Polar Surface Area31.8 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity322
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Adrenergic Antagonists

    Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE. (See all compounds classified as Adrenergic Antagonists.)

    Histamine Antagonists

    Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)