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    Promazine

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 174Xls

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    2D Structure
    Also known as: 53-60-1, Promazine hcl, Sparine, Starazin, Talofen, Promazine (hydrochloride)
    Molecular Formula
    C17H21ClN2S
    Molecular Weight
    320.9  g/mol
    InChI Key
    JIVSXRLRGOICGA-UHFFFAOYSA-N
    FDA UNII
    U16EOR79U4
    A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
    2.1.3 InChI Key
    JIVSXRLRGOICGA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    U16EOR79U4
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrochloride, Promazine

    2. Promazine

    3. Protactyl

    4. Sinophenin

    5. Sparine

    2.3.2 Depositor-Supplied Synonyms

    1. 53-60-1

    2. Promazine Hcl

    3. Sparine

    4. Starazin

    5. Talofen

    6. Promazine (hydrochloride)

    7. Promazine Monohydrochloride

    8. Rp 4560

    9. N,n-dimethyl-3-(10h-phenothiazin-10-yl)propan-1-amine Hydrochloride

    10. Nsc-17468

    11. Promazinehydrochloride

    12. Promazine Hydrochloride [usp]

    13. Mls000069671

    14. U16eor79u4

    15. 10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride

    16. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

    17. N-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

    18. 10-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

    19. Smr000058499

    20. Dsstox_cid_26949

    21. Dsstox_rid_82026

    22. Dsstox_gsid_46949

    23. 10-(gamma-dimethylamino-n-propyl)phenothiazine Hydrochloride

    24. Promazine Hydrochloride (usp)

    25. Chebi:8460

    26. N,n-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride

    27. Chlorowodorek Promazyny

    28. Chlorowodorek Promazyny [polish]

    29. Cas-53-60-1

    30. Sr-01000000228

    31. Ncgc00015829-02

    32. Einecs 200-179-7

    33. Nsc 17468

    34. N-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

    35. 10-(3-[dimethylamino]propyl)phenothiazine Hydrochloride

    36. 10-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

    37. Unii-u16eor79u4

    38. Esparinal

    39. Verofen

    40. Ai3-28022

    41. Sr-01000000228-4

    42. Promazine Chloride

    43. Promazine-d6 Hcl

    44. Prestwick_974

    45. Sparine (tn)

    46. Romtiazin Hydrochloride

    47. Opera_id_41

    48. Sinophenin Hydrochloride

    49. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Hydrochloride

    50. Propazin (pharmaceutical)

    51. Regid_for_cid_5887

    52. Mls001148436

    53. Mls002222285

    54. Schembl123418

    55. Spectrum1500509

    56. 10-(3-dimethylaminopropyl)phenothiazine Hydrochloride

    57. Chembl1200469

    58. Dtxsid4046949

    59. Hms1570k07

    60. Hms1920l14

    61. Pharmakon1600-01500509

    62. Hy-b1225

    63. Nsc17468

    64. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Monohydrochloride

    65. Promazine Hydrochloride [mi]

    66. Tox21_110235

    67. Tox21_500961

    68. 10-h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

    69. Ccg-40284

    70. Nsc757300

    71. S5428

    72. Akos015964305

    73. Tox21_110235_1

    74. Cs-4873

    75. Ks-1384

    76. Lp00961

    77. Nsc-757300

    78. Promazine Hydrochloride [mart.]

    79. Promazine Hydrochloride [vandf]

    80. Promazine Hydrochloride [usp-rs]

    81. Promazine Hydrochloride [who-dd]

    82. Ncgc00015829-12

    83. Ncgc00094262-01

    84. Ncgc00094262-02

    85. Ncgc00094262-03

    86. Ncgc00094262-04

    87. Ncgc00094262-05

    88. Ncgc00261646-01

    89. Ac-18101

    90. Promazine Hydrochloride [green Book]

    91. Eu-0100961

    92. Ft-0674047

    93. Promazine Hydrochloride [orange Book]

    94. Promazine Hydrochloride [ep Monograph]

    95. Wln: T C666 Bn Isj B3n1&1 &gh

    96. D00797

    97. D78322

    98. P 6656

    99. Promazine Hydrochloride [usp Monograph]

    100. Sr-01000000228-2

    101. Sr-01000000228-8

    102. W-105721

    103. Q27108085

    104. Z2784093694

    105. Promazine Hydrochloride, Vetranal(tm), Analytical Standard

    106. 10-(.gamma.-dimethylamino-n-propyl)phenothiazine Hydrochloride

    107. Dimethyl[3-(10h-phenothiazin-10-yl)propyl]amine Hydrochloride

    108. Promazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    109. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Hydrochloride (1:1)

    110. N,n-dimethyl-3-(10h-phenothiazin-10-yl)-1-propanamine Hydrochloride

    111. Promazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    112. Promazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 320.9 g/mol
    Molecular Formula C17H21ClN2S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass320.1113975 g/mol
    Monoisotopic Mass320.1113975 g/mol
    Topological Polar Surface Area31.8 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity285
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)