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    propericiazine

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    PharmaCompass
    $ API Ref.Price (USD/KG) : 620Xls

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    2D Structure
    Also known as: Propericiazine, Pericyazine, 2622-26-6, Propericyazine, Neuleptil, Piperocyanomazine
    Molecular Formula
    C21H23N3OS
    Molecular Weight
    365.5  g/mol
    InChI Key
    LUALIOATIOESLM-UHFFFAOYSA-N
    FDA UNII
    3405M6FD73
    Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
    2.1.2 InChI
    InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
    2.1.3 InChI Key
    LUALIOATIOESLM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
    2.2 Other Identifiers
    2.2.1 UNII
    3405M6FD73
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aolept

    2. Neuleptil

    3. Neuleptyl

    4. Pericyazine

    5. Propericiazine

    2.3.2 Depositor-Supplied Synonyms

    1. Propericiazine

    2. Pericyazine

    3. 2622-26-6

    4. Propericyazine

    5. Neuleptil

    6. Piperocyanomazine

    7. Nemactil

    8. Neulactil

    9. Periciazinum

    10. Aolept

    11. Periciazina

    12. Periciazine [inn]

    13. Bayer 1409

    14. 10-(3-(4-hydroxypiperidino)propyl)phenothiazine-2-carbonitrile

    15. Rp 8909

    16. 2-cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine

    17. Skf 20,716

    18. 6909 Rp

    19. Ic 6002

    20. Rp 8908

    21. Wh 7508

    22. 2-cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine

    23. Propericiazine (jan)

    24. F.i. 6145

    25. Skf 20716

    26. Propericiazine;rp 8909

    27. Cyano-3 ((hydroxy-4 Piperidyl-1)-3 Propyl)-10 Phenothiazine

    28. Nsc-758641

    29. Rp-8909

    30. Chembl251940

    31. 4-piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-

    32. Chebi:31981

    33. 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile

    34. 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10h-phenothiazine-2-carbonitrile

    35. Skf-20716

    36. 3405m6fd73

    37. Ncgc00095086-01

    38. 10-(3-(4-hydroxypiperidin-1-yl)propyl)-10h-phenothiazine-2-carbonitrile

    39. Propericiazine [jan]

    40. Periciazinum [inn-latin]

    41. Periciazina [inn-spanish]

    42. 2-cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine

    43. Nelactil

    44. Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)-

    45. Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]-

    46. Neuleptil (tn)

    47. Einecs 220-071-3

    48. Brn 0576739

    49. Periciazin

    50. Unii-3405m6fd73

    51. 10-[3-(4-hydroxy-1-piperidinyl)propyl]-10h-phenothiazine-2-carbonitrile

    52. Cyano-3 ((hydroxy-4 Piperidyl-1)-3 Propyl)-10 Phenothiazine [french]

    53. 10h-phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-

    54. Spectrum_001614

    55. Starbld0016671

    56. Pericyazine [mi]

    57. Spectrum2_001604

    58. Spectrum3_000748

    59. Spectrum4_000210

    60. Spectrum5_001747

    61. Dsstox_cid_25910

    62. Dsstox_rid_81221

    63. Pericyazine [mart.]

    64. Dsstox_gsid_45910

    65. Bspbio_002336

    66. Kbiogr_000819

    67. Kbioss_002094

    68. Periciazine [who-dd]

    69. Divk1c_000874

    70. Schembl148422

    71. Spectrum1503936

    72. Spbio_001607

    73. Gtpl9216

    74. Dtxsid5045910

    75. Hms502l16

    76. Kbio1_000874

    77. Kbio2_002094

    78. Kbio2_004662

    79. Kbio2_007230

    80. Kbio3_001556

    81. Ninds_000874

    82. Hms1922m18

    83. Pharmakon1600-01503936

    84. Zinc538159

    85. Tox21_111417

    86. Bdbm50346422

    87. Ccg-39062

    88. Nsc758641

    89. Db01608

    90. Nsc 758641

    91. Rp 8909skf 20716

    92. Idi1_000874

    93. Ncgc00095086-02

    94. Ncgc00095086-03

    95. Ncgc00095086-04

    96. Hy-14263

    97. Cas-2622-26-6

    98. Sbi-0051867.p002

    99. Cs-0002963

    100. Ft-0673633

    101. D01485

    102. F77808

    103. Sr-01000872777

    104. Q2622907

    105. Sr-01000872777-1

    106. Brd-k89669299-001-02-7

    107. 10-[3-(4-hydroxy-1-piperidinyl)propyl]-10h-phenothiazine-2-carbonitrile #

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 365.5 g/mol
    Molecular Formula C21H23N3OS
    XLogP33.5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count4
    Exact Mass365.15618354 g/mol
    Monoisotopic Mass365.15618354 g/mol
    Topological Polar Surface Area75.8 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity513
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system.

    5.2 ATC Code

    N - Nervous system

    N05 - Psycholeptics

    N05A - Antipsychotics

    N05AC - Phenothiazines with piperidine structure

    N05AC01 - Periciazine

    5.3 Mechanism of Action

    Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade of the alpha adrenergic receptors as well as antagonism of the D(1) dopamine receptor.