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    Propiomazine

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
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    2D Structure
    Also known as: Largon, Propiomazine hcl, 1240-15-9, Chebi:8492, 70bo17yr03, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-1-propanone monohydrochloride
    Molecular Formula
    C20H25ClN2OS
    Molecular Weight
    376.9  g/mol
    InChI Key
    UGVNGSMLNPWNNA-UHFFFAOYSA-N
    FDA UNII
    70BO17YR03
    Propiomazine Hydrochloride is the hydrochloride salt form of propiomazine, a phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine H1 receptors; Its antipsychotic effect is attributed to antagonistic activities at dopamine and 5-HT2 receptors.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C20H24N2OS.ClH/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;/h6-12,14H,5,13H2,1-4H3;1H
    2.1.3 InChI Key
    UGVNGSMLNPWNNA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    70BO17YR03
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Largon

    2. Propiomazine

    2.3.2 Depositor-Supplied Synonyms

    1. Largon

    2. Propiomazine Hcl

    3. 1240-15-9

    4. Chebi:8492

    5. 70bo17yr03

    6. 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-1-propanone Monohydrochloride

    7. 1-propanone, 1-(10-(2-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-, Monohydrochloride

    8. 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride

    9. Unii-70bo17yr03

    10. Propiomazine Hydrochloride [usp]

    11. Propiomazinhydrochlorid

    12. Surecn720224

    13. Schembl141677

    14. Chembl1201068

    15. Dtxsid80872383

    16. Propiomazine Hydrochloride [mi]

    17. (+/-)-propiomazine Hydrochloride

    18. Propiomazine Hydrochloride [mart.]

    19. Propiomazine Hydrochloride [vandf]

    20. Propiomazine Hydrochloride [who-dd]

    21. Propiomazine Hydrochloride, (+/-)-

    22. C07384

    23. Propiomazine Hydrochloride [orange Book]

    24. Q27108092

    25. 1-propanone, 1-(10-(2-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 376.9 g/mol
    Molecular Formula C20H25ClN2OS
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count5
    Exact Mass376.1376123 g/mol
    Monoisotopic Mass376.1376123 g/mol
    Topological Polar Surface Area48.8 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity441
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2