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    Propoxycaine

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 550-83-4, Propoxycaine hcl, Propoxycaine (hydrochloride), Ravocaine hydrochloride, 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate;hydrochloride, Nsc-760044
    Molecular Formula
    C16H27ClN2O3
    Molecular Weight
    330.8  g/mol
    InChI Key
    GITPCGSPKUQZTE-UHFFFAOYSA-N
    FDA UNII
    K490D39G46
    A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)ethyl 4-amino-2-propoxybenzoate;hydrochloride
    2.1.2 InChI
    InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
    2.1.3 InChI Key
    GITPCGSPKUQZTE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCOC1=C(C=CC(=C1)N)C(=O)OCCN(CC)CC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    K490D39G46
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrochloride, Propoxycaine

    2. Propoxycaine

    3. Propoxyprocaine

    2.3.2 Depositor-Supplied Synonyms

    1. 550-83-4

    2. Propoxycaine Hcl

    3. Propoxycaine (hydrochloride)

    4. Ravocaine Hydrochloride

    5. 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate;hydrochloride

    6. Nsc-760044

    7. Propoxycaine Hydrochloride (200 Mg)

    8. Propoxycaine Hydrochloride [usp]

    9. K490d39g46

    10. Pravocaine Hydrochloride

    11. Propoxycaine Hydrochloride (usp)

    12. Ncgc00016505-01

    13. Win 3459

    14. Cas-550-83-4

    15. Einecs 208-988-7

    16. Unii-k490d39g46

    17. Blockain Hydrochloride

    18. Propoxycainehydrochloride

    19. 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate Monohydrochloride

    20. 4-amino-2-propoxybenzoic Acid 2-(diethylamino)ethyl Ester Hydrochloride

    21. Chembl1769

    22. Dsstox_cid_25325

    23. Dsstox_rid_80804

    24. Dsstox_gsid_45325

    25. Schembl24720

    26. Blockaine Hydrochloride (tn)

    27. Mls002154133

    28. Dtxsid6045325

    29. 3-benzoylpropionicacidoxime

    30. Hms1571c20

    31. Pharmakon1600-01505572

    32. Hy-b1243

    33. Tox21_110462

    34. Nsc760044

    35. Ccg-213485

    36. Cs-4955

    37. Nsc 760044

    38. Propoxycaine Hydrochloride [mi]

    39. Benzoic Acid, 4-amino-2-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride

    40. Propoxycainehydrochloride(200mg)

    41. As-82901

    42. Propoxycaine Hydrochloride [mart.]

    43. Smr001233440

    44. Propoxycaine Hydrochloride [who-dd]

    45. D02099

    46. Propoxycaine Hydrochloride [orange Book]

    47. Propoxycaine Hydrochloride [usp Impurity]

    48. Sr-01000841224

    49. Sr-01000841224-2

    50. Q27281938

    51. 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate Hydrochloride

    52. 4-amino-2-propoxybenzoesaure-ss-diathylamino-athylester-hydrochlorid

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 330.8 g/mol
    Molecular Formula C16H27ClN2O3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass330.1710204 g/mol
    Monoisotopic Mass330.1710204 g/mol
    Topological Polar Surface Area64.8 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity295
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)