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    Propyphenazone

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Isopropyl phenazone, 479-92-5, Isopropylantipyrine, Isopropylphenazone, 4-isopropylantipyrine, Isopropyrine
    Molecular Formula
    C14H18N2O
    Molecular Weight
    230.31  g/mol
    InChI Key
    PXWLVJLKJGVOKE-UHFFFAOYSA-N
    FDA UNII
    OED8FV75PY
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one
    2.1.2 InChI
    InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
    2.1.3 InChI Key
    PXWLVJLKJGVOKE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    OED8FV75PY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one

    2. 4-isopropylantipyrine

    3. Commotional

    4. Demex

    5. Hewedolor Propy

    6. Isoprochin P

    7. Isopropylphenazone

    8. Propylphenazone

    2.3.2 Depositor-Supplied Synonyms

    1. Isopropyl Phenazone

    2. 479-92-5

    3. Isopropylantipyrine

    4. Isopropylphenazone

    5. 4-isopropylantipyrine

    6. Isopropyrine

    7. Isopropylantipyrin

    8. Larodon

    9. Isopropylantipyrinum

    10. Propifenazona

    11. Propyphenazonum

    12. Propyphenazon

    13. Budirol

    14. Cibalgina

    15. Yoshipyrin

    16. 1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one

    17. 1-phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one

    18. 1-phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one

    19. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

    20. Antipyrine, 4-isopropyl-

    21. Chebi:135538

    22. 3h-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-

    23. Oed8fv75py

    24. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

    25. 2,3-dimethyl-4-isopropyl-1-phenyl-3h-pyrazolin-5-one

    26. 3-pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-

    27. 3-pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-

    28. 1,5-dimethyl-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3h-pyrazol-3-one

    29. Propyphenazone (4-isopropylantipyrine)

    30. 4-isopropylantipyrine;isopropylphenazone

    31. Propyphenazone (inn)

    32. 4-isopropyl-1,5-dimethyl-2-phenyl-1h-pyrazol-3(2h)-one

    33. Ncgc00164612-01

    34. Isopropchin

    35. Propifenazone

    36. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

    37. Dsstox_cid_3529

    38. Dsstox_rid_77065

    39. Propyphenazone [inn]

    40. 4-isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone

    41. Dsstox_gsid_23529

    42. Propifenazone [dcit]

    43. Causyth

    44. Propifenazona [inn-spanish]

    45. Propyphenazonum [inn-latin]

    46. Cas-479-92-5

    47. 4-isopropylphenazone

    48. Ccris 6716

    49. Propyphenazone [inn:ban:dcf]

    50. Einecs 207-539-2

    51. Unii-oed8fv75py

    52. Brn 0204533

    53. Yoshipyrin (tn)

    54. 5-pyrazolone, 1-phenyl-2,3-dimethyl-4-isopropyl-

    55. Propyphenazone,(s)

    56. Chemdiv2_002457

    57. Epitope Id:124928

    58. Propyphenazone [mi]

    59. Isopropylantipyrine (jp17)

    60. Schembl23393

    61. 5-24-01-00408 (beilstein Handbook Reference)

    62. Mls004773970

    63. Chembl28318

    64. Propyphenazone [mart.]

    65. Propyphenazone [who-dd]

    66. Dtxsid6023529

    67. Isopropylantipyrine [jan]

    68. Pxwlvjlkjgvoke-uhfffaoysa-

    69. Zinc49151

    70. Hms1375p15

    71. Hy-a0273

    72. Tox21_112233

    73. Mfcd00053368

    74. Propyphenazone [ep Monograph]

    75. S5309

    76. Stk766727

    77. 1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

    78. Akos001725335

    79. Tox21_112233_1

    80. Ccg-266797

    81. Cs-5533

    82. Db13524

    83. Ncgc00164612-02

    84. Ac-12099

    85. Bs-16890

    86. Propyphenazone 1.0 Mg/ml In Acetonitrile

    87. Propyphenazone 100 Microg/ml In Methanol

    88. Smr001495368

    89. Ft-0654525

    90. I0656

    91. D01380

    92. D91192

    93. Q425111

    94. Sr-01000536454

    95. 4-isopropylantipyrine, Analytical Reference Material

    96. Sr-01000536454-1

    97. W-106059

    98. 4-isopropyl-1,5-dimethyl-2-phenyl-3-pyrazolone

    99. Propyphenazone, European Pharmacopoeia (ep) Reference Standard

    100. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one #

    101. Propyphenazone, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 230.31 g/mol
    Molecular Formula C14H18N2O
    XLogP31.7
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass230.141913202 g/mol
    Monoisotopic Mass230.141913202 g/mol
    Topological Polar Surface Area23.6 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity340
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    4.2 ATC Code

    N - Nervous system

    N02 - Analgesics

    N02B - Other analgesics and antipyretics

    N02BB - Pyrazolones

    N02BB04 - Propyphenazone