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2D Structure
Also known as: 179474-85-2, Resolor, Prucalopride succinat, Prucalopride (succinate), R-108512, Butanedioic acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
Molecular Formula
C22H32ClN3O7
Molecular Weight
486.0  g/mol
InChI Key
QZRSNVSQLGRAID-UHFFFAOYSA-N
FDA UNII
4V2G75E1CK

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid
2.1.2 InChI
InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)
2.1.3 InChI Key
QZRSNVSQLGRAID-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
4V2G75E1CK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-amino-5-chloro-n-(1-(3-methoxypropyl)-4-piperidinyl)-2,3-dihydro-1-benzofuran-7-carboxamide

2. Motegrity

3. Prucalopride

4. R 093877

5. R093877

6. Resolor

7. Resotran

8. Resotrans

2.3.2 Depositor-Supplied Synonyms

1. 179474-85-2

2. Resolor

3. Prucalopride Succinat

4. Prucalopride (succinate)

5. R-108512

6. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

7. Prucalopride Succinate [usan]

8. Prucalopride (as Succinate)

9. 4v2g75e1ck

10. 179474-85-2 (succinate)

11. 4-amino-5-chloro-n-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide Succinate

12. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-(1-(3-methoxypropyl)-4-piperidinyl)-7-benzofurancarboxamide (1:1)

13. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

14. Prucalopride Succinate (usan)

15. Resotran

16. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic Acid

17. Resolor (tn)

18. Unii-4v2g75e1ck

19. R-93877

20. Resolor Succinate

21. Motegrity (tn)

22. Prucalopridesuccinate

23. R 108512

24. Mls006011219

25. Schembl1230437

26. Chembl2105748

27. Dtxsid701027749

28. Hms3652b21

29. Hms3885j13

30. Bcp09320

31. Mfcd00948731

32. S4247

33. Akos015994741

34. Prucalopride Succinate [mart.]

35. Ccg-269590

36. Cs-3907

37. Ks-1283

38. Prucalopride Succinate [who-dd]

39. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic Acid

40. Ac-29960

41. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarb

42. Hy-12694

43. Smr004702981

44. Db-065276

45. Prucalopride Succinate [orange Book]

46. Ft-0745512

47. Sw219198-1

48. D10152

49. A812449

50. J-519956

51. Q27260539

52. B0084-470898

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 486.0 g/mol
Molecular Formula C22H32ClN3O7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass485.1928781 g/mol
Monoisotopic Mass485.1928781 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count33
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Resolor is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)


Serotonin 5-HT4 Receptor Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS. (See all compounds classified as Serotonin 5-HT4 Receptor Agonists.)


5.2 ATC Code

A06AX05