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    Pseudoephedrine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Pseudoephedrine hcl, 345-78-8, Otrinol, Rhinalair, Tussaphed, Novafed
    Molecular Formula
    C10H16ClNO
    Molecular Weight
    201.69  g/mol
    InChI Key
    BALXUFOVQVENIU-KXNXZCPBSA-N
    FDA UNII
    6V9V2RYJ8N
    A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10+;/m0./s1
    2.1.3 InChI Key
    BALXUFOVQVENIU-KXNXZCPBSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)NC.Cl
    2.1.5 Isomeric SMILES
    C[C@@H]([C@H](C1=CC=CC=C1)O)NC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    6V9V2RYJ8N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ephedrine Threo Isomer

    2. Isoephedrine

    3. Pseudoephedrine

    4. Pseudoephedrine Hcl

    5. Sudafed

    6. Threo Isomer Of Ephedrine

    2.3.2 Depositor-Supplied Synonyms

    1. Pseudoephedrine Hcl

    2. 345-78-8

    3. Otrinol

    4. Rhinalair

    5. Tussaphed

    6. Novafed

    7. Sudafed

    8. Sudomyl

    9. First Sign

    10. D-pseudoephedrine Hydrochloride

    11. Besan

    12. Sudafed Hydrochloride

    13. (+)-pseudoephedrine Hydrochloride

    14. Pseudophedrine Hydrochloride

    15. Galsud

    16. Efidac 24

    17. 1s,2s-(+)-pseudoephedrine Hydrochloride

    18. Nsc-33634

    19. Nsc-106567

    20. 6v9v2ryj8n

    21. L(+)-pseudoephedrine Hydrochloride

    22. Sinufed

    23. Coadvil

    24. Symptom 2

    25. D-(alpha-(1-methylamino)ethyl)benzyl Alcohol Hydrochloride

    26. Sudafed 12 Hour

    27. Pseudoephedrine, (+)-

    28. Pseudoephedrine, L-(+)-

    29. Suphedrine

    30. Nexafed

    31. Dorcol

    32. Histalet Syrup

    33. L-(+)-pseudoephedrine Hydrochloride

    34. Sun Mark Sinus

    35. Deconsal Ii

    36. Chebi:8604

    37. Sudafed Liquid, Children's

    38. Pediacare Decongestant Drops

    39. Sudafed 24 Hour

    40. (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol Hydrochloride

    41. Benzenemethanol, Hydrochloride, S-(r,r)-

    42. Wln: Qyr & Y1 & M1 & Gh-l

    43. Dimetapp Decongestant

    44. Actifed Sinus Daytime

    45. Cpdd 0050

    46. Benzenemethanol, Hydrochloride, [s-(r*,r*)]-

    47. Einecs 206-462-1

    48. Pseudoephedrine Hydrochloride [usan]

    49. Nsc 33634

    50. Unii-6v9v2ryj8n

    51. Nsc 106567

    52. (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

    53. Topcare 12 Hour Decongestant

    54. D-[.alpha.-(1-methylamino)ethyl]benzyl Alcohol Hydrochloride

    55. Ornex And Maximum Strength Ornex

    56. Sudafed (tn)

    57. Galpseud

    58. Pseudoephedrine, Hydrochloride, L-(+)-

    59. Pseudoephedrine Hydrochloride [usan:usp]

    60. Tylenol Sinus Medication, Maximum Strength

    61. Isoephedrine Hydrochloride

    62. Contac Day & Night Allergy Sinus Day Caplets

    63. Psi-ephedrine Hydrochloride

    64. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (s-(r*,r*))-

    65. Ec 206-462-1

    66. Schembl33285

    67. Mls001304069

    68. Spectrum1500516

    69. Chembl1200724

    70. Sine-off Maximum Strength No Drowsiness Formula Caplets

    71. Dtxsid10889343

    72. Hms1920n04

    73. Pharmakon1600-01500516

    74. Nsc33634

    75. Pseudoephedrine Hydrochloride (usp)

    76. Ccg-39241

    77. Nsc106567

    78. Nsc759616

    79. Akos027383893

    80. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (s-(r*,r*))-, Hydrochloride

    81. Nsc-759616

    82. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride, (.alpha.s)-

    83. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphas)-

    84. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (s-(theta,theta))-

    85. Pseudoephedrine Hydrochloride [mi]

    86. Smr000718787

    87. (+)-pseudoephedrine Hydrochloride, >=98%

    88. P1654

    89. Pseudoephedrine Hydrochloride [mart.]

    90. Pseudoephedrine Hydrochloride [vandf]

    91. Pseudoephedrine Hydrochloride [usp-rs]

    92. Pseudoephedrine Hydrochloride [who-dd]

    93. D00485

    94. 345p788

    95. Pseudoephedrine Hydrochloride [orange Book]

    96. Myfed Component Pseudoephedrine Hydrochloride

    97. Pseudoephedrine Hydrochloride [ep Monograph]

    98. Pseudoephedrine Hydrochloride [usp Monograph]

    99. W-106727

    100. Actahist Component Pseudoephedrine Hydrochloride

    101. Actifed Component Pseudoephedrine Hydrochloride

    102. Aleve-d Component Pseudoephedrine Hydrochloride

    103. Allerfed Component Pseudoephedrine Hydrochloride

    104. Corphed Component Pseudoephedrine Hydrochloride

    105. Histafed Component Pseudoephedrine Hydrochloride

    106. Isoclor Component Pseudoephedrine Hydrochloride

    107. Pseudoephedrine Hydrochloride Component Of Myfed

    108. Q27108108

    109. Triphed Component Pseudoephedrine Hydrochloride

    110. Zyrtec-d Component Pseudoephedrine Hydrochloride

    111. Allegra-d Component Pseudoephedrine Hydrochloride

    112. Bromfed-dm Component Pseudoephedrine Hydrochloride

    113. Mucinex D Component Pseudoephedrine Hydrochloride

    114. Pseudoephedrine Hydrochloride Component Of Actifed

    115. Pseudoephedrine Hydrochloride Component Of Aleve-d

    116. Pseudoephedrine Hydrochloride Component Of Corphed

    117. Pseudoephedrine Hydrochloride Component Of Isoclor

    118. Pseudoephedrine Hydrochloride Component Of Triphed

    119. Semprex-d Component Pseudoephedrine Hydrochloride

    120. Triacin-c Component Pseudoephedrine Hydrochloride

    121. Trilitron Component Pseudoephedrine Hydrochloride

    122. (+)-pseudoephedrine Hydrochloride, Sigma Reference Standard

    123. Bromanate Dm Component Pseudoephedrine Hydrochloride

    124. Dimetane-dx Component Pseudoephedrine Hydrochloride

    125. Hycofenix Component Of Pseudoephedrine Hydrochloride

    126. Pseudoephedrine Hydrochloride Component Of Actahist

    127. Pseudoephedrine Hydrochloride Component Of Allegra-d

    128. Pseudoephedrine Hydrochloride Component Of Allerfed

    129. Pseudoephedrine Hydrochloride Component Of Bromfed-dm

    130. Pseudoephedrine Hydrochloride Component Of Histafed

    131. Pseudoephedrine Hydrochloride Component Of Hycofenix

    132. Pseudoephedrine Hydrochloride Component Of Mucinex D

    133. Pseudoephedrine Hydrochloride Component Of Semprex-d

    134. Pseudoephedrine Hydrochloride Component Of Triacin-c

    135. Pseudoephedrine Hydrochloride Component Of Trilitron

    136. Pseudoephedrine Hydrochloride Component Of Zyrtec-d

    137. Pseudoephedrine Hydrochloride; Threo-ephedrine Hydrochloride

    138. Sine-aid Ib Component Pseudoephedrine Hydrochloride

    139. (1s,2s)-2-(methylamino)-1-phenyl-1-propanol Hydrochloride

    140. Codimal-l.a. 12 Component Pseudoephedrine Hydrochloride

    141. Pseudoephedrine Hydrochloride Component Of Bromanate Dm

    142. Pseudoephedrine Hydrochloride Component Of Dimetane-dx

    143. Pseudoephedrine Hydrochloride Component Of Sine-aid Ib

    144. Advil Allergy Sinus Component Pseudoephedrine Hydrochloride

    145. Children's Advil Cold Component Pseudoephedrine Hydrochloride

    146. Children's Motrin Cold Component Pseudoephedrine Hydrochloride

    147. Pseudoephedrine Hydrochloride Component Of Advil Allergy Sinus

    148. Pseudoephedrine Hydrochloride Component Of Codimal-l.a. 12

    149. (+)-pseudoephedrine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    150. Pseudoephedrine Hydrochloride Component Of Children's Advil Cold

    151. Pseudoephedrine Hydrochloride Component Of Children's Motrin Cold

    152. Pseudoephedrine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    153. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride (1:1), (.alpha.s)-

    154. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride (1:1), (alphas)-

    155. Pseudoephedrine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    156. Pseudoephedrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    157. Pseudoephedrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 201.69 g/mol
    Molecular Formula C10H16ClNO
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass201.0920418 g/mol
    Monoisotopic Mass201.0920418 g/mol
    Topological Polar Surface Area32.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity121
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NamePseudoephedrine hydrochloride
    Drug LabelActive ingredient (in each 5 mL) Purpose Pseudoephedrine hydrochloride 15 mg .............. Nasal decongestant...
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength120mg
    Market StatusOver the Counter
    CompanyRanbaxy; Perrigo

    2 of 6  
    Drug NameSudafed 12 hour
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength120mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    3 of 6  
    Drug NameSudafed 24 hour
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength240mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    4 of 6  
    Drug NamePseudoephedrine hydrochloride
    Drug LabelActive ingredient (in each 5 mL) Purpose Pseudoephedrine hydrochloride 15 mg .............. Nasal decongestant...
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength120mg
    Market StatusOver the Counter
    CompanyRanbaxy; Perrigo

    5 of 6  
    Drug NameSudafed 12 hour
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength120mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    6 of 6  
    Drug NameSudafed 24 hour
    Active IngredientPseudoephedrine hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength240mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Nasal Decongestants

    Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    alpha-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]