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    Pseudoephedrine, Triprolidine Drug Combination

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Pseudophedrine hydrochoride mixture with triprolidine hydrochloride, 8054-27-1, Trifed, (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol;2-[(e)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;dihydrochloride, Decondine, Dtxsid401009332
    Molecular Formula
    C29H39Cl2N3O
    Molecular Weight
    516.5  g/mol
    InChI Key
    CNBCKNGTUYBXON-PLLJCRPXSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol;2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;dihydrochloride
    2.1.2 InChI
    InChI=1S/C19H22N2.C10H15NO.2ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;1-8(11-2)10(12)9-6-4-3-5-7-9;;/h2-3,6-12H,4-5,13-15H2,1H3;3-8,10-12H,1-2H3;2*1H/b18-11+;;;/t;8-,10+;;/m.0../s1
    2.1.3 InChI Key
    CNBCKNGTUYBXON-PLLJCRPXSA-N
    2.1.4 Canonical SMILES
    CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.CC(C(C1=CC=CC=C1)O)NC.Cl.Cl
    2.1.5 Isomeric SMILES
    CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.C[C@@H]([C@H](C1=CC=CC=C1)O)NC.Cl.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Actifed

    2. Pseudoephedrine - Triprolidine

    3. Pseudoephedrine, Triprolidine Drug Combination

    4. Trifed

    2.2.2 Depositor-Supplied Synonyms

    1. Pseudophedrine Hydrochoride Mixture With Triprolidine Hydrochloride

    2. 8054-27-1

    3. Trifed

    4. (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol;2-[(e)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;dihydrochloride

    5. Decondine

    6. Dtxsid401009332

    7. Triprolidine And Pseudoephedrine

    8. Triprolidine Mixture With Pseudoephedrine

    9. Pseudoephedrine Mixture With Triprolidine

    10. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphas)-, Mixt. With 2-((1e)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine Monohydrochloride

    11. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (s-(r*,r*))-, Mixt. With (e)-2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine Monohydrochloride

    12. Triprolidine And Pseudoephedrine Hydrochlorides

    13. Pseudoephedrine Hydrochloride And Triprolidine Hydrochloride

    14. Triprolidine Hydrochloride And Pseudoephedrine Hydrochloride

    2.3 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 516.5 g/mol
    Molecular Formula C29H39Cl2N3O
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count7
    Exact Mass515.2470183 g/mol
    Monoisotopic Mass515.2470183 g/mol
    Topological Polar Surface Area48.4 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity457
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Expectorants

    Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    alpha-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]