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    2D Structure
    Also known as: Cobicistat & elvitegravir & emtricitabine & tenofovir disoproxil fumarate, Cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate, Cobicistat and elvitegravir and emtricitabine and tenofovir disoproxil fumarate, Quad, Quad pill, Quad tablet
    Molecular Formula
    C94H120ClF2N16O27PS3
    Molecular Weight
    2106.7  g/mol
    InChI Key
    FMCLRHTZMTUYMI-JFQFMQNHSA-N
    A pharmaceutical preparation of the ANTI-HIV AGENTS elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate that is used in the treatment of HIV INFECTIONS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid;6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid;1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
    2.1.2 InChI
    InChI=1S/C40H53N7O5S2.C23H23ClFNO5.C19H30N5O10P.C8H10FN3O3S.C4H4O4/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35;1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25;1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5;5-3(6)1-2-4(7)8/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49);4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30);7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1,5-6,13H,2-3H2,(H2,10,11,14);1-2H,(H,5,6)(H,7,8)/b;;;;2-1+/t32-,33-,36+;19-;14-;5-,6+;/m1110./s1
    2.1.3 InChI Key
    FMCLRHTZMTUYMI-JFQFMQNHSA-N
    2.1.4 Canonical SMILES
    CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F.C(=C/C(=O)O)\C(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination

    2. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate

    3. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate Drug Combination

    4. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

    5. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate Drug Combination

    6. Genvoya

    7. Pill, Quad

    8. Quad Pill

    2.2.2 Depositor-Supplied Synonyms

    1. Cobicistat & Elvitegravir & Emtricitabine & Tenofovir Disoproxil Fumarate

    2. Cobicistat + Elvitegravir + Emtricitabine + Tenofovir Disoproxil Fumarate

    3. Cobicistat And Elvitegravir And Emtricitabine And Tenofovir Disoproxil Fumarate

    4. Quad

    5. Quad Pill

    6. Quad Tablet

    7. Evg-cobi-ftc-tdf

    8. Cobicistat, Elvitegravir, Emtricitabine, Tenofovir

    9. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil

    10. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate

    11. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate

    12. Cobicistat Mixture With Elvitegravir And Emtricitabine And Tenofovir Disoproxil

    13. Cobicistat Mixture With Elvitegravir, Emtricitabine And Tenofovir Disoproxil Fumarate

    14. Elvitegravir Mixture With Cobicistat And Emtricitabine And Tenofovir Disoproxil Fumarate

    15. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

    16. 1430117-57-9

    2.3 Create Date
    2009-10-19
    3 Chemical and Physical Properties
    Molecular Weight 2106.7 g/mol
    Molecular Formula C94H120ClF2N16O27PS3
    Hydrogen Bond Donor Count10
    Hydrogen Bond Acceptor Count40
    Rotatable Bond Count48
    Exact Mass2105.7098720 g/mol
    Monoisotopic Mass2104.7065172 g/mol
    Topological Polar Surface Area655 Ų
    Heavy Atom Count144
    Formal Charge0
    Complexity3010
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameStribild
    PubMed HealthElvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
    Drug ClassesAnti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
    Drug LabelSTRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
    Active Ingredientelvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
    Dosage FormTablet
    RouteOral
    Strength200mg; 150mg; 300mg
    Market StatusPrescription
    CompanyGilead Sciences

    2 of 2  
    Drug NameStribild
    PubMed HealthElvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
    Drug ClassesAnti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
    Drug LabelSTRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
    Active Ingredientelvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
    Dosage FormTablet
    RouteOral
    Strength200mg; 150mg; 300mg
    Market StatusPrescription
    CompanyGilead Sciences

    4.2 Drug Indication

    Treatment of human immunodeficiency virus 1 (HIV 1) infection in adults aged 18 years and over who are antiretroviral treatment-nave or are infected with HIV 1 without known mutations associated with resistance to any of the three antiretroviral agents in Stribild.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-HIV Agents

    Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)

    5.2 ATC Code

    J05AR09