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    Technical details about Radgocitabine, learn more about the structure, uses, toxicity, action, side effects and more

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    Radgocitabine

    DEVELOPMENTS

    PharmaCompass

    Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

    One Pharma aims to be one of the leading generic companies in Europe.

    2D Structure
    1. Also known as: 135598-68-4, Tas-109, Radgocitabine, (2r,3s,4s,5r)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile, Tas 109, 00m634hd2v
    Molecular Formula
    C10H12N4O4
    Molecular Weight
    252.23  g/mol
    InChI Key
    DCYBPMFXJCWXNB-JWIUVKOKSA-N
    FDA UNII
    00M634HD2V
    Radgocitabine is an analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile
    2.1.2 InChI
    InChI=1S/C10H12N4O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17)/t5-,6+,8-,9+/m0/s1
    2.1.3 InChI Key
    DCYBPMFXJCWXNB-JWIUVKOKSA-N
    2.1.4 Canonical SMILES
    C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)C#N
    2.1.5 Isomeric SMILES
    C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)C#N
    2.2 Other Identifiers
    2.2.1 UNII
    00M634HD2V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2'-cyano-2'-deoxyarabinofuranosylcytosine

    2. 2'-cyano-2'deoxy-1-beta-d-arabinofuranosylcytosine

    2.3.2 Depositor-Supplied Synonyms

    1. 135598-68-4

    2. Tas-109

    3. Radgocitabine

    4. (2r,3s,4s,5r)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile

    5. Tas 109

    6. 00m634hd2v

    7. 2'-cyano-2'-deoxy-1-(beta-d-arabinofuranosyl)cytosine

    8. (2r,3s,4s,5r)-2-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile

    9. Unii-00m634hd2v

    10. Radgocitabine [who-dd]

    11. Radgocitabine [inn]

    12. Chembl337450

    13. Schembl1006241

    14. Dtxsid30159474

    15. Chebi:145435

    16. Dfp10917

    17. Ex-a1611

    18. Hy-16445a

    19. 4-amino-l-(2-cyano-2-deoxy-beta-d-arabinofuranosyl)- 2(1h)-pyrimidinone

    20. Akos030573293

    21. Cs-6837

    22. Db11667

    23. Ns00069241

    24. A857813

    25. 1-(2-deoxy-2-cyano-beta-d-arabinofuranosyl)cytosine

    26. Q27231358

    27. 1-(2-c-cyano-2-deoxy-beta-d-arabino-pentofuranosyl) Cytosine

    28. 2'-c-cyano-2'-deoxy-1-beta-d-arabino-pentofuranosyl-cytosine

    29. 2'-cyano-2'-deoxy-1-(.beta.-d-arabinofuranosyl)cytosine

    30. 4-amino-1-(2-cyano-2-deoxy-beta-d-arabinofuranosyl)pyrimidin-2(1h)-one

    31. 2(1h)-pyrimidinone, 4-amino-1-(2-cyano-2-deoxy-.beta.-d-arabinofuranosyl)-

    32. 4-amino-l-(2-cyano-2-deoxy-.beta.-d-arabinofuranosyl)- 2(1h)-pyrimidinone

    33. (2r,3s,4s,5r)-2-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-3-carbonitrile

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 252.23 g/mol
    Molecular Formula C10H12N4O4
    XLogP3-2.4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area132
    Heavy Atom Count18
    Formal Charge0
    Complexity466
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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