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    Ramosetron HCl

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    Xls

    Filters

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    2D Structure
    Also known as: 132907-72-3, Ramosetron hcl, Nasea, Irribow, Ym060, Ym-060
    Molecular Formula
    C17H18ClN3O
    Molecular Weight
    315.8  g/mol
    InChI Key
    XIXYTCLDXQRHJO-RFVHGSKJSA-N
    FDA UNII
    9551LHD87E
    Ramosetron Hydrochloride is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity. Upon administration, ramosetron selectively binds to and blocks the activity of 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS), suppressing chemotherapy-induced nausea and vomiting.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1-methylindol-3-yl)-[(5R)-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methanone;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
    2.1.3 InChI Key
    XIXYTCLDXQRHJO-RFVHGSKJSA-N
    2.1.4 Canonical SMILES
    CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4.Cl
    2.1.5 Isomeric SMILES
    CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9551LHD87E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazol

    2. Methanone, (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-, Monohydrochloride, (r)-

    3. Nasea

    4. Ramosetron

    5. Ym 060

    6. Ym-060

    7. Ym060

    2.3.2 Depositor-Supplied Synonyms

    1. 132907-72-3

    2. Ramosetron Hcl

    3. Nasea

    4. Irribow

    5. Ym060

    6. Ym-060

    7. (r)-(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzo[d]imidazol-6-yl)methanone Hydrochloride

    8. Ym 060

    9. Ramosetron.hcl

    10. Ramosetron (hydrochloride)

    11. (r)-(-)-ramosetron Hydrochloride

    12. 9551lhd87e

    13. Dsstox_cid_1223

    14. (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone;hydrochloride

    15. (r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazole Hydrochloride

    16. Dsstox_rid_76021

    17. Dsstox_gsid_21223

    18. Ramosetron Hydrochloride (jan)

    19. Ramosetron Hydrochloride [jan]

    20. Ccris 7704

    21. Cas-132907-72-3

    22. (r)-(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-

    23. Unii-9551lhd87e

    24. (r)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1h-benzimidazole Hydrochloride

    25. Nasea Od

    26. (-)-(r)-5-((1-methyl-1h-indol-3-yl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazole Monohydrochloride

    27. (-)-(r)-5-[(1-methyl-1h-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1h-benzimidazole Monohydrochloride

    28. Methanone, (1-methyl-1h-indol-3-yl)((6r)-4,5,6,7-tetrahydro-1h-benzimidazol-6-yl)-, Hydrochloride (1:1)

    29. Methanone, (1-methyl-1h-indol-3-yl)[(6r)-4,5,6,7-tetrahydro-1h-benzimidazol-6-yl]-, Hydrochloride (1:1)

    30. Irribow (tn)

    31. Nasea (tn)

    32. Ramosetron Hydrochloride,(s)

    33. Methanone, (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-, Monohydrochloride, (r)-

    34. Schembl447023

    35. Chembl3181841

    36. Dtxsid3021223

    37. Chebi:32088

    38. Act02590

    39. Amy15420

    40. Hy-b0595

    41. Ym060ym-060

    42. Tox21_112441

    43. Mfcd19441800

    44. Ramosetron Hydrochloride [mi]

    45. S3723

    46. Akos015895434

    47. Tox21_112441_1

    48. Ccg-267653

    49. Ks-1311

    50. Ramosetron Hydrochloride [mart.]

    51. Ncgc00167437-02

    52. Ramosetron Hydrochloride [who-dd]

    53. (1-methyl-1h-indol-3-yl)[(5r)-4,5,6,7-tetrahydro-1h-benzimidazol-5-yl]methanone Hydrochloride

    54. (1-methyl-1h-indol-3-yl)[(6r)-4,5,6,7-tetrahydro-1h-benzimidazol-6-yl]methanone Hydrochloride

    55. Methanone, (1-methyl-1h-indol-3-yl)((5r)-4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-, Monohydrochloride

    56. R-145

    57. D02016

    58. 907r723

    59. A806524

    60. Q27271742

    61. (r)-(-)-5-[(1-methylindol-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole Hydrochloride

    62. (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone;hydrochloride.

    63. (r)-(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzo[d]imidazol-5-yl)methanone Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 315.8 g/mol
    Molecular Formula C17H18ClN3O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass315.1138399 g/mol
    Monoisotopic Mass315.1138399 g/mol
    Topological Polar Surface Area50.7 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity413
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)