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    Ranitidine Bismuth Citrate

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PATENTS & EXCLUSIVITIES

    ANALYTICAL

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    2D Structure
    Also known as: Ranitidine bismutrex, Tritec, Gr 122311x, Gr-122311x, 7aj51i17kg, 128345-62-0
    Molecular Formula
    C19H27BiN4O10S
    Molecular Weight
    712.5  g/mol
    InChI Key
    XAUTYMZTJWXZHZ-UHFFFAOYSA-K
    FDA UNII
    7AJ51I17KG
    Ranitidine Bismuth Citrate is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    bismuth;1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;;+3/p-3
    2.1.3 InChI Key
    XAUTYMZTJWXZHZ-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Bi+3]
    2.2 Other Identifiers
    2.2.1 UNII
    7AJ51I17KG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Azanplus

    2. Gr 122311x

    3. Gr-122311x

    4. Gr122311x

    5. Pylorid

    6. Raniberl

    7. Tritec

    2.3.2 Depositor-Supplied Synonyms

    1. Ranitidine Bismutrex

    2. Tritec

    3. Gr 122311x

    4. Gr-122311x

    5. 7aj51i17kg

    6. 128345-62-0

    7. Ranitidine (bismuth Citrate)

    8. Azamplus

    9. Elicodil

    10. Helirad

    11. Pylorisan

    12. Unii-7aj51i17kg

    13. Ranitidine Bismuth Citrate [usan]

    14. Ranitidine Bismuth Citrate [usan:ban]

    15. Schembl415304

    16. Chembl2111286

    17. Dtxsid801027716

    18. Ranitidine Bismuth Citrate [mi]

    19. N-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine, Compound With Bismuth(3(+)) Citrate (1:1)

    20. Ranitidine Bismuth Citrate [vandf]

    21. Ranitidine Bismuth Citrate [mart.]

    22. Ranitidine Bismuth Citrate [who-dd]

    23. Ranitidine Bismuth Citrate [orange Book]

    24. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3(+)) Salt (1:1), Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1)

    25. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3+) Salt (1:1), Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1)

    26. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3+) Salt, Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1:1)

    27. N-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine, Compound With Bismuth(3+) Citrate (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 712.5 g/mol
    Molecular Formula C19H27BiN4O10S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count11
    Exact Mass712.12519 g/mol
    Monoisotopic Mass712.12519 g/mol
    Topological Polar Surface Area252 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity558
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count1
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine H2 Antagonists

    Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    4.2 ATC Code

    A - Alimentary tract and metabolism

    A02 - Drugs for acid related disorders

    A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)

    A02BA - H2-receptor antagonists

    A02BA07 - Ranitidine bismuth citrate