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    Rhodamine B

    ACTIVE PHARMA INGREDIENTS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 3,330Xls

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    2D Structure
    Also known as: 81-88-9, Basic violet 10, Brilliant pink b, Tetraethylrhodamine, Rhodamine o, Rheonine b
    Molecular Formula
    C28H31ClN2O3
    Molecular Weight
    479.0  g/mol
    InChI Key
    PYWVYCXTNDRMGF-UHFFFAOYSA-N
    FDA UNII
    K7G5SCF8IL
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [9-(2-carboxyphenyl)-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;chloride
    2.1.2 InChI
    InChI=1S/C28H30N2O3.ClH/c1-5-29(6-2)19-13-15-23-25(17-19)33-26-18-20(30(7-3)8-4)14-16-24(26)27(23)21-11-9-10-12-22(21)28(31)32;/h9-18H,5-8H2,1-4H3;1H
    2.1.3 InChI Key
    PYWVYCXTNDRMGF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](CC)CC)C=C3O2)C4=CC=CC=C4C(=O)O.[Cl-]
    2.2 Other Identifiers
    2.2.1 UNII
    K7G5SCF8IL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Rhodamine B Acetate

    2. Rhodamine B Chloride

    3. Rhodamine B Dihydride

    4. Tetraethylrhodamine

    2.3.2 Depositor-Supplied Synonyms

    1. 81-88-9

    2. Basic Violet 10

    3. Brilliant Pink B

    4. Tetraethylrhodamine

    5. Rhodamine O

    6. Rheonine B

    7. Rhodamine Fb

    8. Calcozine Red Bx

    9. Symulex Magenta F

    10. Rhodamine

    11. Rhodamine B Chloride

    12. Rhodamine S

    13. Geranium Lake N

    14. Rhodamine Ba

    15. Rhodamine Bf

    16. Rhodamine Bl

    17. Rhodamine Bn

    18. Rhodamine Bs

    19. Rhodamine Bx

    20. Rhodamine Bxl

    21. Rhodamine Bxp

    22. Edicol Suppa Rose Bs

    23. Acid Brilliant Pink B

    24. Symulex Pink F

    25. Adc Rhodamine B

    26. Rhodamine Fb Cl

    27. Ikada Rhodamine B

    28. Rhodamine B Extra

    29. Basic Rose Extract

    30. Iragen Red L-u

    31. Aizen Rhodamine Bh

    32. Akiriku Rhodamine B

    33. Takaoka Rhodamine B

    34. Mitsui Rhodamine Bx

    35. Rhodamine Ba Export

    36. Aizen Rhodamine Bhc

    37. Basonyl Red 545

    38. C.i. Basic Violet 10

    39. Diabasic Rhodamine B

    40. Elcozine Rhodamine B

    41. D And C Red No. 19

    42. Edicol Supra Rose B

    43. Rhodamine B Extra S

    44. C.i. 45170

    45. Rhodamine, Blue Shade

    46. Edicol Supra Rose Bs

    47. Rhodamine Lake Red B

    48. Ci Food Red 15

    49. Rhodamine, Tetraethyl-

    50. Basic Rose Red

    51. Cerise Toner X1127

    52. C.i. Food Red 15

    53. 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium Chloride

    54. Cogilor Red 321.10

    55. Eriosin Rhodamine B

    56. Hexacol Rhodamine B Extra

    57. D&c Red 19

    58. Red No. 213

    59. Violet Zasadita 10

    60. Food Red 15

    61. Rhodamine B 20-7470

    62. Rhodamine B Extra M 310

    63. Fd And C Red No. 19

    64. Symulex Rhodamine B Toner F

    65. Rhodamine B500 Hydrochloride

    66. Calcozine Rhodamine Bxp

    67. 11411 Red

    68. Sicilian Cerise Toner A-7127

    69. C.i. No. 45170

    70. Cosmetic Brilliant Pink Bluish D Conc

    71. Ci 45170

    72. Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, Chloride

    73. Mfcd00011931

    74. K7g5scf8il

    75. Tetraethyldiamino-o-carboxyphenyl Xanthenyl Chloride

    76. Chebi:52334

    77. 9-o-carboxyphenyl-6-diethylamino-3-ethylimino-3-isoxanthene, 3-ethochloride

    78. Nsc-10475

    79. Rhodamineb

    80. Basic Violet 10;brilliant Pink B;rhodamine O;tetraethylrhodamine

    81. [9-(2-carboxyphenyl)-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;chloride

    82. Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, Chloride (1:1)

    83. (9-(o-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene) Diethylammonium Chloride

    84. Ethanaminium, N-(9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)-n-ethyl-, Chloride

    85. Rhodamine B500

    86. Basonyl Red 540

    87. Basonyl Red 545fl

    88. Ci Basic Violet 10

    89. Rhodamine S [russian]

    90. D&c Red No.19

    91. Fd&c Red No. 19

    92. D&c Red No. 19

    93. N-(9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)-n-ethylethanaminium Chloride

    94. N-[9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene]-n-ethylethanaminium Chloride

    95. D & C Red No.19

    96. Ethanaminium, N-[9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene]-n-ethyl-, Chloride

    97. Violet Zasadita 10 [czech]

    98. Nsc41837

    99. Ccris 3985

    100. Hsdb 5244

    101. Rhodamine B (c.i. 45170)

    102. Einecs 201-383-9

    103. Unii-k7g5scf8il

    104. Nsc 10475

    105. Rhodamines

    106. Rhodamine?b

    107. [9-(o-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene] Diethylammonium Chloride

    108. Rhodamine B 500

    109. Rhodamine B Solution

    110. Calcozine Rhodamine Bl

    111. Calcozine Rhodamine Bx

    112. Rhodamine B [mi]

    113. Rhodamine B [hsdb]

    114. Rhodamine B [iarc]

    115. Dsstox_cid_22369

    116. Dsstox_rid_80008

    117. Ethanaminium, N-(9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)-n-ethyl-,chloride

    118. Dsstox_gsid_42369

    119. Schembl16280

    120. Aka213 [inci]

    121. D & C Red No. 19

    122. Aka213

    123. Chembl428971

    124. Dtxsid6042369

    125. Rose B W 3005

    126. Aka-213

    127. Amy3544

    128. Basic Violet 10 [inci]

    129. Hy-y0016

    130. Nsc10475

    131. Tox21_301450

    132. Nsc-41837

    133. Akos000283060

    134. D&c Red No. 19 (delisted)

    135. Ccg-269534

    136. Cs-7637

    137. Fd&c Red No. 19 (delisted)

    138. Ammonium, (9-(o-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)diethyl-, Chloride

    139. Cas-81-88-9

    140. N-(9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)-n-e- Thylethanaminium Chloride

    141. Ncgc00255803-01

    142. As-17153

    143. C.i. 749

    144. Ethanaminium, N-(9-(2-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene)-n-e- Thyl-, Chloride

    145. Sy010955

    146. D&c Red No. 19 (delisted) [ii]

    147. Diethyl-m-aminophenolphthalein Hydrochloride

    148. Fd&c Red No. 19 (delisted) [ii]

    149. Ft-0622587

    150. R0014

    151. R0040

    152. C19517

    153. D88566

    154. Q429022

    155. Rhodamine B Chloride 100 Microg/ml In Acetonitrile

    156. 9-(2-carboxyphenyl)-3,6-bis(diethylamino) Xanthylium Chloride

    157. 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthenium Chloride

    158. 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthyliumchloride

    159. Wln: T C666 Bo Eyj Euk2&2 Ir Bvq& Mn2&2 &q &g

    160. [9-(o-carboxyphenyl)-6-(diethylamino)-3h-xanthen-3-ylidene] Diethyl-ammonium Chloride

    161. Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, Chloride (1:1), Dimer

    162. 14728-79-1

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 479.0 g/mol
    Molecular Formula C28H31ClN2O3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass478.2023205 g/mol
    Monoisotopic Mass478.2023205 g/mol
    Topological Polar Surface Area52.8 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity811
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Fluorescent Dyes

    Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)

    4.2 Absorption, Distribution and Excretion

    ... WAS METABOLIZED SIMILARLY IN DOGS, RATS & RABBITS, AS EVIDENCED BY CHROMATOGRAPHIC ANALYSIS OF THEIR URINE & FECAL EXTRACTS. CMPD WAS EXTENSIVELY ABSORBED FROM GI TRACT: OF 1% GIVEN IN DIET, ONLY 3-5% WAS RECOVERED UNCHANGED IN URINE & FECES.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V16 227 (1978)

    RHODAMINE B EXHIBITS HIGH PLASMA PROTEIN BINDING.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V16 228 (1978)

    INTENSITY OF DYE COLOR IN PANCREATIC JUICE OF DOGS DECR IN ORDER: BASIC FUCHSINE, ACRIDINE RED, NEW FUCHSINE, RHODAMINE B, PHENOL RED, RHODAMINE 6G.

    PMID:4469707 HONG SS; YONSEI MED J 15 (2): 51 (1974)

    The adsorption equilibrium (as determined by Langmuir's or Freundlich's equations) of microbial suspensions containing Rhodamine B, and melting temperature of Rhodamine B-calf thymus DNA solution were determined. The adsorption constant of dye to cells for Rhodamine B was 6.86 cal/mol (adsorptive affinity in Langmuir's equation) and 2.86 (for the constant K in Freundlich's equation). Melting temperature values for Rhodamine B calf thymus DNA solution increased with dye concentration.

    PMID:2495832 Ogawa T et al; Bull Environ Contam Toxicol 42 (3): 402-8 (1989)

    4.3 Metabolism/Metabolites

    ... DE-ETHYLATED ENZYMATICALLY; 2 OF 3 OBSERVED METABOLITES WERE IDENTIFIED AS N,N'-DIETHYL-3,6-DIAMINOFLUORAN & 3,6-DIAMINOFLUORAN.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V16 228 (1978)