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    Ridinilazole

    DEVELOPMENTS

    DIGITAL CONTENT

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    2D Structure
    Also known as: 308362-25-6, Ridinilazole [inn], Smt19969, Smt-19969, Ridinilazole [usan], Chembl3753858
    Molecular Formula
    C24H16N6
    Molecular Weight
    388.4  g/mol
    InChI Key
    UHQFBTAJFNVZIV-UHFFFAOYSA-N
    FDA UNII
    06DX01190R
    Ridinilazole is a narrow-spectrum antibiotic with potential activity against Clostridioides difficile infection (CDI). Upon oral administration, ridinilazole exerts its bactericidal activity against C. difficile through inhibition of cell division. This suppresses bacterial toxin production and inhibits the associated inflammatory response. Compared to other antibiotics that treat C. difficile, ridinilazole does not deplete intestinal bacteria and preserves the intestinal bacterial activity and the associated bile acid metabolome.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-pyridin-4-yl-6-(2-pyridin-4-yl-3H-benzimidazol-5-yl)-1H-benzimidazole
    2.1.2 InChI
    InChI=1S/C24H16N6/c1-3-19-21(29-23(27-19)15-5-9-25-10-6-15)13-17(1)18-2-4-20-22(14-18)30-24(28-20)16-7-11-26-12-8-16/h1-14H,(H,27,29)(H,28,30)
    2.1.3 InChI Key
    UHQFBTAJFNVZIV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC2=C(C=C1C3=CC4=C(C=C3)N=C(N4)C5=CC=NC=C5)NC(=N2)C6=CC=NC=C6
    2.2 Other Identifiers
    2.2.1 UNII
    06DX01190R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (2,2' Bis(4-pyridyl) 3h,3'h 5,5' Bibenzimidazole

    2. 2,2'-dipyridin-4-yl-1h,1'h-5,5'-bibenzimidazole

    3. Smt19969

    2.3.2 Depositor-Supplied Synonyms

    1. 308362-25-6

    2. Ridinilazole [inn]

    3. Smt19969

    4. Smt-19969

    5. Ridinilazole [usan]

    6. Chembl3753858

    7. 5,5'-bi-1h-benzimidazole, 2,2'-di-4-pyridinyl-

    8. 06dx01190r

    9. 2,2'-di(pyridin-4-yl)-1h,1'h-5,5'-bibenzo[d]imidazole

    10. 2-pyridin-4-yl-6-(2-pyridin-4-yl-3h-benzimidazol-5-yl)-1h-benzimidazole

    11. 2,2'-di(pyridin-4-yl)-1h,1'h-5,5'-bi(benzimidazole)

    12. P-pyben

    13. Unii-06dx01190r

    14. Ridinilazole [who-dd]

    15. Schembl413723

    16. Schembl17867397

    17. Schembl19235713

    18. Gtpl10853

    19. Dtxsid101028337

    20. Smt19969smt19969

    21. Bdbm50134759

    22. Mfcd28963972

    23. Who 10075

    24. Zinc113778168

    25. Cs-6591

    26. Db15308

    27. Lx-0216

    28. Hy-16753

    29. D80826

    30. Q25102246

    31. 2,2'-dipyridin-4-yl-1h,1'h-5,5'-bibenzimidazole

    32. 2,2'-bis(4-pyridyl)-3h,3'h-5,5'-bibenzimidazole

    33. 2-(pyridin-4-yl)-6-[2-(pyridin-4-yl)-1h-1,3-benzodiazol-5-yl]-1h-1,3-benzodiazole

    2.4 Create Date
    2007-08-09
    3 Chemical and Physical Properties
    Molecular Weight 388.4 g/mol
    Molecular Formula C24H16N6
    XLogP33.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass388.14364454 g/mol
    Monoisotopic Mass388.14364454 g/mol
    Topological Polar Surface Area83.1 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity524
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of Clostridium difficile infection

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)