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    Rilmenidine Phosphate

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
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    2D Structure
    Also known as: 85409-38-7, Rilmenidine dihydrogen phosphate, Rilmenidine (phosphate), S 3341-3, 2-oxazolamine, n-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1), N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid
    Molecular Formula
    C10H19N2O5P
    Molecular Weight
    278.24  g/mol
    InChI Key
    ZJCOWRFWZOAVFY-UHFFFAOYSA-N
    FDA UNII
    59QD64Q32M
    Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid
    2.1.2 InChI
    InChI=1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4)
    2.1.3 InChI Key
    ZJCOWRFWZOAVFY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC1C(C2CC2)NC3=NCCO3.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    59QD64Q32M
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(n-(dicyclopropylmethyl)amino)oxazoline

    2. 2-(n-(dicyclopropylmethyl)amino)oxazoline Phosphate Salt

    3. Hyperium

    4. Oxaminozoline

    5. Rilmenidine

    6. S 3341

    7. S 3341 3

    8. S-3341

    9. S-3341-3

    10. S3341

    11. S33413

    2.3.2 Depositor-Supplied Synonyms

    1. 85409-38-7

    2. Rilmenidine Dihydrogen Phosphate

    3. Rilmenidine (phosphate)

    4. S 3341-3

    5. 2-oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, Phosphate (1:1)

    6. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric Acid

    7. 59qd64q32m

    8. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine Phosphate

    9. Rilmenidinephosphate

    10. Einecs 287-106-2

    11. Unii-59qd64q32m

    12. 4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamine Phosphate (1:1)

    13. 2-oxazolamine, 4,5-dihydro-n-(dicyclopropylmethyl)-, Phosphate (1:1)

    14. (dicyclopropylmethyl)(4,5-dihydro-2-oxazolyl)ammonium Dihydrogen Phosphate

    15. Schembl1231349

    16. Dtxsid50234616

    17. Rilmenidine For System Suitability

    18. Rilmenidine Phosphate [mi]

    19. Bcp13443

    20. Mfcd00875846

    21. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine; Phosphoric Acid

    22. Rilmenidine Hydrogen Phosphate

    23. S7548

    24. Rilmenidine Phosphate [mart.]

    25. Akos015900521

    26. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric Acid

    27. Rilmenidine Phosphate [who-dd]

    28. Ccg-267224

    29. Hy-100490b

    30. As-15125

    31. Cs-0020190

    32. Ft-0656776

    33. A14256

    34. S-3341

    35. 409r387

    36. A841323

    37. S-3341-3

    38. W-104082

    39. Q27261715

    40. Rilmenidine Dihydrogen Phosphate [ep Monograph]

    41. (5-methylpyridin-2-yl)piperidin-4-yl-aminedihydrochloride

    42. 2-((dicyclopropylmethyl)amino)-2-oxazoline Phosphate

    43. Dicyclopropylmethyl-(4,5-dihydrooxazol-2-yl)ammonium Phosphate

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 278.24 g/mol
    Molecular Formula C10H19N2O5P
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass278.10315871 g/mol
    Monoisotopic Mass278.10315871 g/mol
    Topological Polar Surface Area111 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity269
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)