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    Ritanserin

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    MARKET PLACE

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    2D Structure
    Also known as: 87051-43-2, Tiserton, Ritanserina, Ritanserine, Ritanserinum, R-55667
    Molecular Formula
    C27H25F2N3OS
    Molecular Weight
    477.6  g/mol
    InChI Key
    JUQLTPCYUFPYKE-UHFFFAOYSA-N
    FDA UNII
    145TFV465S
    A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    2.1.2 InChI
    InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
    2.1.3 InChI Key
    JUQLTPCYUFPYKE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3
    2.2 Other Identifiers
    2.2.1 UNII
    145TFV465S
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 6-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5h-thiazolo(3,2-a)pyrimidin-5-one

    2. R 55667

    3. R-55667

    4. R55667

    5. Ritanserin Hydrochloride

    6. Ritanserin Tartrate

    2.3.2 Depositor-Supplied Synonyms

    1. 87051-43-2

    2. Tiserton

    3. Ritanserina

    4. Ritanserine

    5. Ritanserinum

    6. R-55667

    7. R 55,667

    8. 6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    9. 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one

    10. Mfcd00069341

    11. 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5h-thiazolo-(3,2-a)pyrimidin-5-one

    12. Nsc-758470

    13. Mls000069360

    14. Chembl267777

    15. 6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    16. 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5h-[1,3]thiazolo[3,2-a]pyrimidin-5-one

    17. Chebi:64195

    18. 145tfv465s

    19. Ncgc00015877-06

    20. Smr000058511

    21. Dsstox_cid_22594

    22. Dsstox_rid_80055

    23. Dsstox_gsid_42594

    24. 5h-thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-

    25. 6-[2-[4-(bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    26. 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[2,3-b]pyrimidin-5-one

    27. Ritanserine [french]

    28. Ritanserinum [latin]

    29. Ritanserina [spanish]

    30. 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    31. Cas-87051-43-2

    32. Sr-01000000024

    33. Ritanserin [usan:inn:ban]

    34. Unii-145tfv465s

    35. Ritanserin, Powder

    36. Tiserton (tn)

    37. 5h-thiazolo[3,2-a]pyrimidin-5-one, 6-[2-[4-bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-

    38. 6-[2-[4-[bis(p-fluorophenyl)methylene]-piperidino]ethyl]-7-methyl-5h-thiazolo-[3,2-a]pyrimidin-5-one

    39. Spectrum_001830

    40. Ritanserin [mi]

    41. Lopac-r-103

    42. Ritanserin [inn]

    43. Opera_id_1609

    44. Ritanserin (usan/inn)

    45. Spectrum2_001560

    46. Spectrum3_001023

    47. Spectrum5_001504

    48. Ritanserin [usan]

    49. Ritanserin [vandf]

    50. Gtpl97

    51. Cid_5074

    52. Ritanserin [mart.]

    53. Ritanserin [who-dd]

    54. Lopac0_001083

    55. Regid_for_cid_5074

    56. Schembl49227

    57. Bspbio_002805

    58. Kbioss_002335

    59. Mls001148629

    60. Divk1c_000192

    61. Spbio_001440

    62. Dtxsid9042594

    63. Hms500j14

    64. Kbio1_000192

    65. Kbio2_002332

    66. Kbio2_004900

    67. Kbio2_007468

    68. Kbio3_002025

    69. Ninds_000192

    70. Hms2093e19

    71. Hms2233m22

    72. Hms3263i08

    73. Hms3268o04

    74. Hms3373o19

    75. Hms3412n14

    76. Hms3676n14

    77. Pharmakon1600-01503421

    78. Zinc538314

    79. Bcp13728

    80. Tox21_110251

    81. Tox21_501083

    82. Bdbm50001775

    83. Ccg-39338

    84. Nsc758470

    85. Nsc805597

    86. Akos015909799

    87. Tox21_110251_1

    88. Db12693

    89. Lp01083

    90. Nsc 758470

    91. Nsc-805597

    92. Sdccgsbi-0051053.p004

    93. 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thia

    94. Idi1_000192

    95. Ncgc00015877-01

    96. Ncgc00015877-02

    97. Ncgc00015877-03

    98. Ncgc00015877-04

    99. Ncgc00015877-05

    100. Ncgc00015877-07

    101. Ncgc00015877-08

    102. Ncgc00015877-09

    103. Ncgc00015877-11

    104. Ncgc00015877-15

    105. Ncgc00022447-03

    106. Ncgc00022447-04

    107. Ncgc00022447-05

    108. Ncgc00178460-01

    109. Ncgc00261768-01

    110. 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one

    111. Ac-30888

    112. Bs-49232

    113. Hy-10791

    114. Sy274388

    115. Sbi-0051053.p003

    116. Db-056967

    117. B6898

    118. Cs-0002823

    119. Eu-0101083

    120. Ft-0630948

    121. R-103

    122. D05738

    123. Ab00053288_14

    124. 051r432

    125. A848404

    126. L001003

    127. R 55667r 55667

    128. Q3937260

    129. Sr-01000000024-3

    130. Sr-01000000024-4

    131. Brd-k40887525-001-02-9

    132. Brd-k40887525-001-14-4

    133. Ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    134. 6-[2-[4-bis(4-fluorophenyl)methylene]-1-piperidinyl]-

    135. (+)-6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one

    136. (ritanserin)6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1h-indolizin-5-one

    137. (ritanserin)6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one

    138. 6-(2-(4-[bis(4-fluorophenyl)methylene]-1-piperidinyl)ethyl)-7-methyl-5h-[1,3]thiazolo[3,2-a]pyrimidin-5-one #

    139. 6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one

    140. 6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one

    141. 6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (ritanserin)

    142. 6-(2-{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(ritanserin)

    143. 6-[2-[4-[bis(4-fluorophenyl)-methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]-pyrimidin-5-one

    144. E2j

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 477.6 g/mol
    Molecular Formula C27H25F2N3OS
    XLogP35.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass477.16863993 g/mol
    Monoisotopic Mass477.16863993 g/mol
    Topological Polar Surface Area61.2 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity877
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidepressive Agents, Second-Generation

    A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)