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    Roxatidine Acetate Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 93793-83-0, Roxatidine acetate hcl, Altat, Gastralgin, Hoe 760, Tzu-0460
    Molecular Formula
    C19H29ClN2O4
    Molecular Weight
    384.9  g/mol
    InChI Key
    FEWCTJHCXOHWNL-UHFFFAOYSA-N
    FDA UNII
    60426GOR1E
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
    2.1.3 InChI Key
    FEWCTJHCXOHWNL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    60426GOR1E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hoe 760

    2. Hoe-760

    3. N-(3-(3-(n(1)-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide

    4. Tzu 0460

    5. Tzu-0460

    2.3.2 Depositor-Supplied Synonyms

    1. 93793-83-0

    2. Roxatidine Acetate Hcl

    3. Altat

    4. Gastralgin

    5. Hoe 760

    6. Tzu-0460

    7. Hoe-760

    8. Roxatidine (acetate Hydrochloride)

    9. Pifatidine Hydrochloride

    10. Nsc-760384

    11. Hoe 062 [roxatidine]

    12. 60426gor1e

    13. 2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamide Hydrochloride

    14. 2-acetoxy-n-[3-[3-(1-piperidinomethylphenoxy]propyl]acetamide Hydrochloride

    15. Mfcd00941429

    16. 98793-83-0

    17. Neo H2

    18. Dsstox_cid_26670

    19. Dsstox_rid_81809

    20. Dsstox_gsid_46670

    21. Aceroxatidine Hydrochloride

    22. 2-oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethyl Acetate Hydrochloride

    23. 2-oxo-2-(3-(3-(piperidin-1-ylmethyl)phenoxy)propylamino)ethyl Acetate Hydrochloride

    24. Smr000469144

    25. Tzu 0460

    26. Cas-93793-83-0

    27. Ccris 3347

    28. Ncgc00167499-01

    29. Xarcin

    30. Unii-60426gor1e

    31. Sr-01000763240

    32. Altat (tn)

    33. Roxatidine Acetate Hydrochloride [usan:jan]

    34. 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamide Acetate (ester) Hydrochloride

    35. Acetamide, 2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-, Monohydrochloride

    36. Acetamide, 2-hydroxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)-, Acetate, Hydrochloride

    37. N-(3-((alpha-piperidino-m-tolyl)oxy)propyl)glycolamide Acetate (ester), Monohydrochloride

    38. Mls001401443

    39. Mls002153806

    40. Schembl667643

    41. Chembl2104871

    42. Dtxsid2046670

    43. Chebi:32107

    44. Hy-b0305a

    45. Akp-004

    46. Amy8936

    47. Pharmakon1600-01502334

    48. Bcp10517

    49. N-(3-(3-(n(1)-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide

    50. Tox21_112500

    51. Tox21_112954

    52. Nsc760384

    53. S1880

    54. 2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamidehydrochloride

    55. Akos015894912

    56. Tox21_112500_1

    57. Ab07712

    58. Ccg-101016

    59. Nc00266

    60. Nsc 760384

    61. [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] Acetate;hydrochloride

    62. 2-(acetyloxy)-n-[3-[3-(1-piperidinyl-methyl)phenoxy]propyl]- Acetamide Monohydrochloride

    63. 2-oxo-2-[[3-[3-(1-piperidylmethyl)phenoxy]propyl]amino]ethyl Acetate Hydrochloride

    64. Acetamide, 2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl-, Monohydrochloride

    65. Ncgc00167499-02

    66. Ac-26444

    67. Acetamide, 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)-, Acetate (ester), Hydrochloride

    68. As-14306

    69. Sy111342

    70. Ft-0630983

    71. R0178

    72. Roxatidine Acetate Hydrochloride [mi]

    73. Sw197646-3

    74. Roxatidine Acetate Hydrochloride (jp17/usan)

    75. Roxatidine Acetate Hydrochloride [jan]

    76. C90611

    77. D01467

    78. Roxatidine Acetate Hydrochloride [usan]

    79. 2-oxo-2-(3-(3-(piperidin-1-ylmethyl)phenoxy

    80. Roxatidine Acetate Hydrochloride [mart.]

    81. Roxatidine Acetate Hydrochloride [who-dd]

    82. 793r830

    83. A844708

    84. Sr-01000763240-4

    85. Q27263158

    86. 2-acetoxy-n-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide Hydrochloride

    87. 2-oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethylacetatehydrochloride

    88. N-(3-((.alpha.-piperidino-m-tolyl)oxy)propyl)glycolamide Acetate Monohydrochloride

    89. [2-oxidanylidene-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] Ethanoate Hydrochloride

    90. Acetic Acid [2-oxo-2-[3-[3-(1-piperidinylmethyl)phenoxy]propylamino]ethyl] Ester Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 384.9 g/mol
    Molecular Formula C19H29ClN2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass384.1815851 g/mol
    Monoisotopic Mass384.1815851 g/mol
    Topological Polar Surface Area67.9 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity410
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine H2 Antagonists

    Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)