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    Rufloxacin Hydrochloride

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    2D Structure
    Also known as: 101363-10-4, Mf 934, Nsc-759835, Chebi:8909, Rufloxacin (inn), Y521xm2900
    Molecular Formula
    C17H18FN3O3S
    Molecular Weight
    363.4  g/mol
    InChI Key
    NJCJBUHJQLFDSW-UHFFFAOYSA-N
    FDA UNII
    Y521XM2900
    Rufloxacin is a quinolone antibiotic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
    2.1.2 InChI
    InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
    2.1.3 InChI Key
    NJCJBUHJQLFDSW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C2=C(C=C3C4=C2SCCN4C=C(C3=O)C(=O)O)F
    2.2 Other Identifiers
    2.2.1 UNII
    Y521XM2900
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 9-fluoro-10-(n-(4'-methyl)piperazinyl)-7-oxo-2,3-dihydro-7h-pyrido(1,2,3de)-1,4-benzothiazine-6-carboxylic Acid

    2. Mf 934

    3. Mf-934

    4. Rufloxacin Hydrobromide

    5. Rufloxacin Hydrochloride

    6. Rufloxacin Monohydrobromide

    7. Rufloxacin Monohydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 101363-10-4

    2. Mf 934

    3. Nsc-759835

    4. Chebi:8909

    5. Rufloxacin (inn)

    6. Y521xm2900

    7. 7h-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic Acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-

    8. Rufloxacine

    9. Rufloxacino

    10. Rufloxacinum

    11. Rufloxacin [inn]

    12. 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic Acid

    13. 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic Acid;9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic Acid

    14. Smr000466373

    15. Rufloxacine [french]

    16. Rufloxacinum [latin]

    17. Rufloxacino [spanish]

    18. Rufloxacin [inn:ban]

    19. Sr-01000612324

    20. Ncgc00074024-02

    21. Unii-y521xm2900

    22. Rufloxacin [mi]

    23. Rufloxacin [who-dd]

    24. Mls000759502

    25. Mls001424127

    26. Schembl135502

    27. Chembl295619

    28. Dtxsid6048412

    29. Hms2051k22

    30. Hms2090n07

    31. Hms3264m18

    32. Hms3393k22

    33. Hms3715p09

    34. Pharmakon1600-01502335

    35. Zinc538328

    36. Hy-b0902

    37. Rkl10066

    38. Bbl008945

    39. Nsc759835

    40. Stk711124

    41. Akos004120047

    42. Ccg-100908

    43. Cs-4367

    44. Db13772

    45. Nc00158

    46. Nsc 759835

    47. As-79943

    48. Ft-0631011

    49. D02474

    50. Ab00474020-18

    51. Ab00474020-20

    52. Ab00474020_21

    53. 363r104

    54. Q3942356

    55. Sr-01000612324-5

    56. Sr-01000612324-6

    57. 7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0^{5,13]trideca-5(13),6,8,11-tetraene-11-carboxylic Acid

    58. 7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic Acid

    59. 8-fluoro-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6h-1-thia-3a-aza-phenalene-5-carboxylic Acid

    60. 8-fluoro-9-(4-methylpiperazin-1-yl)-6-oxo-2,3-dihydro-6h-1-thia-3a-aza-phenalene-5-carboxylic Acid

    61. 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic Acid

    62. 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic Acid

    63. 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic Acid

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 363.4 g/mol
    Molecular Formula C17H18FN3O3S
    XLogP3-0.3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count2
    Exact Mass363.10529078 g/mol
    Monoisotopic Mass363.10529078 g/mol
    Topological Polar Surface Area89.4 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity608
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

    4.2 ATC Code

    J - Antiinfectives for systemic use

    J01 - Antibacterials for systemic use

    J01M - Quinolone antibacterials

    J01MA - Fluoroquinolones

    J01MA10 - Rufloxacin