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    Technical details about Seladelpar, learn more about the structure, uses, toxicity, action, side effects and more

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    Seladelpar

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass

    Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

    One Pharma aims to be one of the leading generic companies in Europe.

    2D Structure
    1. Also known as: 851528-79-5, Mbx-8025, Seladelpar [inn], Seladelpar [usan], Rwj-800025, Chembl230158
    Molecular Formula
    C21H23F3O5S
    Molecular Weight
    444.5  g/mol
    InChI Key
    JWHYSEDOYMYMNM-QGZVFWFLSA-N
    FDA UNII
    7C00L34NB9
    Seladelpar (MBX-8025) has been used in trials studying the treatment of Hyperlipidemia.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid
    2.1.2 InChI
    InChI=1S/C21H23F3O5S/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26/h4-10,17H,3,11-13H2,1-2H3,(H,25,26)/t17-/m1/s1
    2.1.3 InChI Key
    JWHYSEDOYMYMNM-QGZVFWFLSA-N
    2.1.4 Canonical SMILES
    CCOC(COC1=CC=C(C=C1)C(F)(F)F)CSC2=CC(=C(C=C2)OCC(=O)O)C
    2.1.5 Isomeric SMILES
    CCO[C@H](COC1=CC=C(C=C1)C(F)(F)F)CSC2=CC(=C(C=C2)OCC(=O)O)C
    2.2 Other Identifiers
    2.2.1 UNII
    7C00L34NB9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)sulfanyl)-2-methylphenoxy)acetic Acid

    2.3.2 Depositor-Supplied Synonyms

    1. 851528-79-5

    2. Mbx-8025

    3. Seladelpar [inn]

    4. Seladelpar [usan]

    5. Rwj-800025

    6. Chembl230158

    7. 7c00l34nb9

    8. Mbx 8025

    9. 851528-79-5 (free Base)

    10. (r)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic Acid

    11. (+)-mbx-8025

    12. ((4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic Acid

    13. 2-[4-[(2r)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic Acid

    14. Acetic Acid, (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)-

    15. Acetic Acid, 2-(4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)-

    16. Seladelpar (usan/inn)

    17. Seladelpar [usan:inn]

    18. Seladelpar [who-dd]

    19. Schembl392331

    20. Unii-7c00l34nb9

    21. Gtpl11137

    22. Mbx8025

    23. Dtxsid001045332

    24. Bjb52879

    25. Ex-a1512

    26. Bdbm50213714

    27. Akos037649258

    28. Db12390

    29. Compound 3r [pmid: 17524639]

    30. Ac-36246

    31. Bs-17646

    32. Hy-19522

    33. Mbx-8025; Rwj-800025

    34. Cs-0015622

    35. C76734

    36. D11256

    37. A914807

    38. Q27268037

    39. (r)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propylthio)-2-methylphenoxy)acetic Acid

    40. (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)sulfanyl)-2-methylphenoxy)acetic Acid Peroxisome Proliferator Activated Receptor (ppar) Agonist,antihyperlipidaemic

    41. (r)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)-thio)-2-methylphenoxy)acetic Acid

    42. Acetic Acid, (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)- ((4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic Acid

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 444.5 g/mol
    Molecular Formula C21H23F3O5S
    XLogP35.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count11
    Exact Mass444.12182949 g/mol
    Monoisotopic Mass444.12182949 g/mol
    Topological Polar Surface Area90.3 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity511
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of primary biliary cholangitis

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Hypolipidemic Agents

    Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

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