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    Sevelamer Carbonate

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    Sevelamer Carbonate

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    2D Structure
    Also known as: 845273-93-0, 2-propen-1-amine polymer with (chloromethyl)oxirane carbonate, Carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine, Sevelamercarbonate, Gt-335-012, Chembl1201799
    Molecular Formula
    C7H14ClNO4
    Molecular Weight
    211.64  g/mol
    InChI Key
    PADGNZFOVSZIKZ-UHFFFAOYSA-N
    A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine
    2.1.2 InChI
    InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
    2.1.3 InChI Key
    PADGNZFOVSZIKZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C=CCN.C1C(O1)CCl.C(=O)(O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Carbonate, Sevelamer

    2. Gt335 012

    3. Gt335-012

    4. Gt335012

    5. Hydrochloride, Sevelamer

    6. Renagel

    7. Sevelamer

    8. Sevelamer Hydrochloride

    2.2.2 Depositor-Supplied Synonyms

    1. 845273-93-0

    2. 2-propen-1-amine Polymer With (chloromethyl)oxirane Carbonate

    3. Carbonic Acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

    4. Sevelamercarbonate

    5. Gt-335-012

    6. Chembl1201799

    7. Bcp13411

    8. Ex-a4743

    9. Akos037515475

    10. Hs-0081

    11. Gt335-012

    12. Gt335 012;gt335-012;gt335012;carbonate, Sevelamer

    2.3 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 211.64 g/mol
    Molecular Formula C7H14ClNO4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass211.0611356 g/mol
    Monoisotopic Mass211.0611356 g/mol
    Topological Polar Surface Area96.1 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity81.4
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Renvela is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

    Renvela is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus 1. 78 mmol/l.

    Renvela should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.

    Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

    Sevelamer carbonate Winthrop is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus > 1. 78 mmol/L.

    Sevelamer carbonate Winthrop should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Chelating Agents

    Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]
    5.3 ATC Code

    V03AE02

    V03AE02