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    Sibutramine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 267Xls

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    2D Structure
    Also known as: 125494-59-9, Sibutramine hydrochloride monohydrate, Reductil, Sibutramine hydrochloride hydrate, Sibutramine hydrochloride [usan], Bts 54524
    Molecular Formula
    C17H29Cl2NO
    Molecular Weight
    334.3  g/mol
    InChI Key
    KFNNPQDSPLWLCX-UHFFFAOYSA-N
    FDA UNII
    OGM0YHD1WF
    Sibutramine Hydrochloride is the hydrochloride salt form of sibutramine, a phenethylamine derivative with appetite depressant property. Sibutramine hydrochloride metabolites M1 and M2 competitively inhibit the reuptake of norepinephrine, serotonin, and to a lesser degree dopamine by pre-synaptic nerve terminals, thereby promoting a sense of satiety, leading to a decrease in calorie intake, and possibly an increase in resting metabolic rate. This agent does not exhibit anticholinergic or antihistaminic effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine;hydrate;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2
    2.1.3 InChI Key
    KFNNPQDSPLWLCX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C.O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    OGM0YHD1WF
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (r)-ddms

    2. Bts 54 524

    3. Bts 54524

    4. Bts-54524

    5. Di-desmethylsibutramine

    6. Didesmethylsibutramine

    7. Mono-desmethylsibutramine

    8. N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-n,n-dimethylamine Hcl

    9. Reductil

    10. Sibutramine

    11. Sibutramine Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 125494-59-9

    2. Sibutramine Hydrochloride Monohydrate

    3. Reductil

    4. Sibutramine Hydrochloride Hydrate

    5. Sibutramine Hydrochloride [usan]

    6. Bts 54524

    7. Ogm0yhd1wf

    8. Bts-54524

    9. Sibutramine (hydrochloride Monohydrate)

    10. Sibutramine Hydrochloride Civ

    11. 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine;hydrate;hydrochloride

    12. Sibutramine Hydrochloride Hydrate (jan)

    13. Cyclobutanemethanamine, 1-(4-chlorophenyl)-n,n-dimethyl-alpha-(2-methylpropyl)-, Hydrochloride, Hydrate (1:1:1)

    14. Sibutramine, Hydrochloride Monohydrate

    15. Sibutramine Hydrochloride Hydrate [jan]

    16. Unii-ogm0yhd1wf

    17. Meridia (tn)

    18. Sibutramine Hcl H2o

    19. Cpd000472527

    20. Schembl42301

    21. (+-)-1-(p-chlorophenyl)-alpha-isobutyl-n,n-dimethylcyclobutanemethylamine Hydrochloride Monohydrate

    22. Mls001424319

    23. Sibutramine Hydrochloride,(s)

    24. Chembl3989830

    25. Sibutramine Hydrochloride (usp)

    26. Dtxsid00925148

    27. Kes-524

    28. Bcp07236

    29. Akos015855356

    30. Ac-4218

    31. Ccg-101169

    32. Ks-1192

    33. 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethyl-butan-1-amine Hydrate Hydrochloride

    34. Sibutramine Hydrochloride [mart.]

    35. Sibutramine Hydrochloride [vandf]

    36. Bs164401

    37. Cyclobutanemethanamine, 1-(4-chlorophenyl)-n,n-dimethyl-alpha-(2-methylpropyl)-, Hydrochloride, Monohydrate, (+-)-

    38. Hy-14470

    39. Smr000472527

    40. 1-(1-(4-chlorophenyl)cyclobutyl)-n,n,3

    41. Db-049918

    42. Trimethylbutan-1-amine Hydrochloride Hydrate

    43. 1-(1-(4-chlorophenyl)cyclobutyl)-n,n,3-

    44. Ft-0651268

    45. Sibutramine Hydrochloride Monohydrate- Bio-x

    46. D02571

    47. Sibutramine Hydrochloride [orange Book]

    48. Sibutramine Hydrochloride [usp Impurity]

    49. 485s007

    50. A805388

    51. Sibutramine Hydrochloride Monohydrate [mi]

    52. Sibutramine Hydrochloride Monohydrate [hsdb]

    53. Q27285644

    54. Sibutramine Hydrochloride Monohydrate [who-dd]

    55. Sibutramine Hydrochloride Monohydrate, >=98% (hplc), Solid

    56. 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethyl-1-butanamine Hydrate Hydrochloride

    57. N,n-dimethyl-1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutylamine Hydrochloride Monohydrate

    58. N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine Hydrochloride Monohydrate

    59. Sibutramine Hydrochloride Monohydrate 1.0 Mg/ml In Methanol (as Anhydrous Free Base)

    60. (+/-)-1-(p-chlorophenyl)-.alpha.-isobutyl-n,n-dimethylcyclobutanemethylamine Hydrochloride Monohydrate

    61. 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine--hydrogen Chloride--water (1/1/1)

    62. Cyclobutanemethanamine, 1-(4-chlorophenyl)-n,n-dimethyl-.alpha.-(2-methylpropyl)-, Hydrochloride, Hydrate (1:1:1)

    63. Cyclobutanemethanamine, 1-(4-chlorophenyl)-n,n-dimethyl-a-(2-methylpropyl)-, Hydrochloride, Monohydrate, (+/-)-

    64. Sibutramine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 334.3 g/mol
    Molecular Formula C17H29Cl2NO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass333.1626199 g/mol
    Monoisotopic Mass333.1626199 g/mol
    Topological Polar Surface Area4.2 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity275
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidepressive Agents

    Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

    Appetite Depressants

    Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)