Please Wait
Applying Filters...
menu
    • menu
    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Sodium Acetate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS & EXCLUSIVITIES

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 1Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 127-09-3, Acetic acid, sodium salt, Sodium acetate anhydrous, Acetic acid sodium salt, Sodium acetate, anhydrous, Anhydrous sodium acetate
    Molecular Formula
    C2H3NaO2
    Molecular Weight
    82.03  g/mol
    InChI Key
    VMHLLURERBWHNL-UHFFFAOYSA-M
    FDA UNII
    NVG71ZZ7P0
    The trihydrate sodium salt of acetic acid, which is used as a source of sodium ions in solutions for dialysis and as a systemic and urinary alkalizer, diuretic, and expectorant.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;acetate
    2.1.2 InChI
    InChI=1S/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
    2.1.3 InChI Key
    VMHLLURERBWHNL-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC(=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    NVG71ZZ7P0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Sodium Acetate Trihydrate

    2. Sodium Acetate, Anhydrous

    2.3.2 Depositor-Supplied Synonyms

    1. 127-09-3

    2. Acetic Acid, Sodium Salt

    3. Sodium Acetate Anhydrous

    4. Acetic Acid Sodium Salt

    5. Sodium Acetate, Anhydrous

    6. Anhydrous Sodium Acetate

    7. Sodium Ethanoate

    8. Fema No. 3024

    9. Sodium-acetate

    10. Acetic Acid, Sodium Salt (1:1)

    11. Sodium;acetate

    12. Mfcd00012459

    13. Natriumacetat

    14. Sodium Acetate,anhydrous

    15. Nvg71zz7p0

    16. Chebi:32954

    17. Sodii Acetas

    18. Natriumazetat

    19. Nsc-77459

    20. Natrium Aceticum

    21. Octan Sodny [czech]

    22. Caswell No. 741a

    23. Natriumacetat [german]

    24. Chembl1354

    25. Fema Number 3024

    26. Octan Sodny

    27. Naoac

    28. Hsdb 688

    29. Sodium Acetate In Plastic Container

    30. Einecs 204-823-8

    31. Nsc 77459

    32. Unii-nvg71zz7p0

    33. Epa Pesticide Chemical Code 044006

    34. Sodiumacetate

    35. Sodium Aceate

    36. Acona

    37. Scfa

    38. Ch3coona

    39. Acetic Acidsodium Salt

    40. Sodium Acetate Solution

    41. Short Chain Fatty Acids

    42. Sodium Acetate ,(s)

    43. Ch3co2na

    44. Dsstox_cid_7044

    45. Ec 204-823-8

    46. Dsstox_rid_78290

    47. Sodium Acetate [mi]

    48. Dsstox_gsid_27044

    49. Sodium Acetate, Acs Reagent

    50. Sodium Acetate [fhfi]

    51. Sodium Acetate [hsdb]

    52. Dtxsid2027044

    53. Sodium Acetate [who-dd]

    54. Sodium Acetate Solution, 0.3 M

    55. Sodium Acetate, Biochemical Grade

    56. Sodium Acetate Anhydrous Acs Usp

    57. Tox21_202741

    58. Sodium Acetate Anhydrous [ii]

    59. Akos003052995

    60. Akos015837569

    61. Sodium Acetate, Bioxtra, >=99.0%

    62. Db09395

    63. Sodium Acetate, Reagentplus(r), 99%

    64. Sodium Acetate, For Hplc, >=99.5%

    65. Sodium Acetate,anhydrous [vandf]

    66. Acetate, 1m Buffer Solution, Ph, 3.0

    67. Acetate, 1m Buffer Solution, Ph, 3.5

    68. Acetate, 1m Buffer Solution, Ph, 4.0

    69. Acetate, 1m Buffer Solution, Ph, 5.0

    70. Acetate, 1m Buffer Solution, Ph, 5.5

    71. Ncgc00260289-01

    72. Sodium Acetate, Ar, Anhydrous, >=99%

    73. Sodium Acetate, Lr, Anhydrous, >=98%

    74. Cas-127-09-3

    75. E262

    76. Sodium Acetate, Acs Reagent, >=99.0%

    77. B7296

    78. Ft-0635282

    79. Ft-0659959

    80. Ft-0689166

    81. S0559

    82. Sodium Acetate Anhydrous, >99%, Fcc, Fg

    83. Sodium Acetate Anhydrous [orange Book]

    84. Sodium Acetate, 99.995% Trace Metals Basis

    85. Sodium Acetate, Saj First Grade, >=98.0%

    86. Sodium Acetate, Trace Metals Grade, 99.99%

    87. Sodium Acetate Anhydrous Acs Grade 12kg

    88. Sodium Acetate, Jis Special Grade, >=98.5%

    89. Sodium Acetate, Vetec(tm) Reagent Grade, 98%

    90. Sodium Acetate Anhydrous [usp Monograph]

    91. A805637

    92. Q339940

    93. J-005463

    94. Sodium Acetate, For Hplc, 99.0-101.0% (nt)

    95. Sodium Acetate, Puriss., Anhydrous, >=98%, Powder

    96. Sodium Acetate, Anhydrous, Reagentplus(r), >=99.0%

    97. Sodium Acetate, Anhydrous, For Molecular Biology, >=99%

    98. Sodium Acetate, For Electrophoresis, >=99%, Crystalline

    99. Sodium Acetate, 1m Aqueous Solution, Ph 4.5, Rnase Free

    100. Sodium Acetate, 3m Aqueous Solution, Ph 4.5, Autoclaved

    101. Sodium Acetate, 3m Aqueous Solution, Ph 5.2, Autoclaved

    102. Sodium Acetate, 3m Aqueous Solution, Ph 5.2, Rnase Free

    103. Sodium Acetate, 3m Aqueous Solution, Ph 7.0, Autoclaved

    104. Sodium Acetate, 3m Aqueous Solution, Ph 7.0, Rnase Free

    105. Sodium Acetate, Meets Usp Testing Specifications, Anhydrous

    106. Sodium Acetate, United States Pharmacopeia (usp) Reference Standard

    107. Sodium Acetate Solution, Bioultra, For Molecular Biology, ~3 M In H2o

    108. Sodium Acetate, Bioultra, For Luminescence, Anhydrous, >=99.0% (nt)

    109. Sodium Acetate, Puriss. P.a., Acs Reagent, Reag. Ph. Eur., Anhydrous

    110. Sodium Acetate, Anhydrous, Bioultra, For Luminescence, For Molecular Biology, >=99.0% (nt)

    111. Sodium Acetate, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99.0%

    112. Mettler-toledo Calibration Substance Me 30130599, Sodium Acetate Anhydrous, Tracable To Primary Standards (lgc)

    113. Sodium Acetate Solution, Nmr Reference Standard, 50 Mm In D2o (99.9 Atom % D), Water 1 %, Nmr Tube Size 3 Mm X 8 In.

    114. Sodium Acetate, Powder, Bioreagent, For Electrophoresis, Suitable For Cell Culture, Suitable For Insect Cell Culture, >=99%

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 82.03 g/mol
    Molecular Formula C2H3NaO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass82.00307362 g/mol
    Monoisotopic Mass82.00307362 g/mol
    Topological Polar Surface Area40.1 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity34.6
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameSodium acetate in plastic container
    Active IngredientSodium acetate anhydrous
    Dosage FormInjectable
    RouteInjection
    Strength2meq/ml
    Market StatusPrescription
    CompanyHospira

    2 of 2  
    Drug NameSodium acetate in plastic container
    Active IngredientSodium acetate anhydrous
    Dosage FormInjectable
    RouteInjection
    Strength2meq/ml
    Market StatusPrescription
    CompanyHospira

    4.2 Therapeutic Uses

    Diuretics; Expectorants; Pharmaceutic Aids

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    /FORMER USE/: HYOSCYAMUS SODIUM ACETATE, & PHENOBARBITAL ELIXIR COMBINES SMOOTH MUSCLE ANTISPASMODIC ACTION OF ... HYOSCYAMUS, WITH URINARY ALKALINIZING & DIURETIC EFFECTS OF SODIUM ACETATE, & SEDATIVE EFFECTS OF PHENOBARBITAL. /IT IS/ USED IN MANAGEMENT OF CYSTITIS & FOR BLADDER IRRITATION.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 86:00

    DOSAGE OF ELIXIR OF HYOSCYAMUS CMPD /CONTAINING SODIUM ACETATE & PHENOBARBITAL/ IS 5 ML GIVEN 3 TIMES DAILY BEFORE MEALS.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 86:00

    ... /SODIUM ACETATE/ HAS BEEN USED FOR PARENTERAL THERAPY OF ACIDOTIC CONDITIONS. IT IS BOTH A SYSTEMIC & URINARY ALKALIZER. /SODIUM ACETATE TRIHYDRATE, USP/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 772

    For more Therapeutic Uses (Complete) data for SODIUM ACETATE (8 total), please visit the HSDB record page.

    4.3 Drug Indication

    Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Sodium is the principal cation of extracellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution. Acetate ions acts as hydrogen ion acceptor which is alternative to bicarbonate.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Increased Large Intestinal Motility [PE]
    5.3 ATC Code

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05X - I.v. solution additives

    B05XA - Electrolyte solutions

    B05XA08 - Sodium acetate

    5.4 Absorption, Distribution and Excretion

    Absorption

    It is readily available in the circulation after IV administration.

    Route of Elimination

    Both the sodium and bicarbonate ions are excreted mainly in the urine. Some sodium is excreted in the feces, and small amounts may also be excreted in saliva, sweat, bile and pancreatic secretions.

    5.5 Metabolism/Metabolites

    In liver, sodium acetate is being metabolized into bicarbonate. To form bicarbonate, acetate is slowly hydrolyzed to carbon dioxide and water, which are then converted to bicarbonate by the addition of a hydrogen ion.

    THE ACETATE ION IS RAPIDLY & COMPLETELY METABOLIZED BY BODY, & CONSEQUENTLY ADMIN OF SODIUM ACETATE IS EVENTUALLY EQUIVALENT TO GIVING SODIUM BICARBONATE. /SODIUM ACETATE TRIHYDRATE, USP/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 772

    CONSTANT RATE INFUSIONS OF SODIUM ACETATE GIVEN TO VOLUNTEERS, AT 4 MMOL/KG/HR INCR PLASMA ACETATE BY ONLY 0.41 MMOL/L, INDICATING A HIGH ACETATE METABOLIZING CAPACITY IN MAN.

    KVEIM MH R ET AL; J OSLO CITY HOSP: 30 (8): 101 (1980)

    Readily metabolized outside the liver.

    American Medical Association. AMA Drug Evaluations Annual 1991. Chicago, IL: American Medical Association, 1991., p. 723

    5.6 Mechanism of Action

    It works as a source of sodium ions especially in cases of hyponatremic patients. Sodium has a primary role in regulating extracellular fluid volume. It controls water distribution, fluid and electrolyte balance and the osmotic pressure of body fluids. Sodium is also involved in nerve conduction, muscle contraction, acid-base balance and cell nutrient uptake.