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    Sodium Alginate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: Sodium alginate, 9005-38-3, Natriumglucuronat, Schembl20919851, Ft-0621962, Ft-0670280
    Molecular Formula
    C6H9NaO7
    Molecular Weight
    216.12  g/mol
    InChI Key
    MSXHSNHNTORCAW-UHFFFAOYSA-M
    Salts and esters of ALGINIC ACID that are used as HYDROGELS; DENTAL IMPRESSION MATERIALS, and as absorbent materials for surgical dressings (BANDAGES, HYDROCOLLOID). They are also used to manufacture MICROSPHERES and NANOPARTICLES for DIAGNOSTIC REAGENT KITS and DRUG DELIVERY SYSTEMS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate
    2.1.2 InChI
    InChI=1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1
    2.1.3 InChI Key
    MSXHSNHNTORCAW-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1(C(C(OC(C1O)O)C(=O)[O-])O)O.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Alginate

    2. Alginate, Barium

    3. Alginate, Calcium

    4. Alginate, Copper

    5. Alginate, Potassium

    6. Alginate, Sodium

    7. Alginate, Sodium Calcium

    8. Alginates

    9. Alginic Acid, Barium Salt

    10. Alginic Acid, Calcium Salt

    11. Alginic Acid, Copper Salt

    12. Alginic Acid, Potassium Salt

    13. Alginic Acid, Sodium Salt

    14. Alloid G

    15. Barium Alginate

    16. Calcium Alginate

    17. Calcium Alginate, Sodium

    18. Calginat

    19. Copper Alginate

    20. Kalrostat

    21. Kalrostat 2

    22. Kaltostat

    23. Poly(mannuronic Acid), Sodium Salt

    24. Potassium Alginate

    25. Sodium Alginate

    26. Sodium Calcium Alginate

    27. Vocoloid

    28. Xantalgin

    2.2.2 Depositor-Supplied Synonyms

    1. Sodium Alginate

    2. 9005-38-3

    3. Natriumglucuronat

    4. Schembl20919851

    5. Ft-0621962

    6. Ft-0670280

    7. Sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate

    2.3 Create Date
    2005-09-18
    3 Chemical and Physical Properties
    Molecular Weight 216.12 g/mol
    Molecular Formula C6H9NaO7
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count1
    Exact Mass216.02459690 g/mol
    Monoisotopic Mass216.02459690 g/mol
    Topological Polar Surface Area130 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity210
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count5
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mesh Heading: Radiation-protective agents, hemostatics, biocompatible materials

    National Library of Medicine, SIS; ChemIDplus Record for Algin (9005-38-3). Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

    EXPTL USE: Alginate therapy (20 mg Na alginate; 40 mg manucol SS/LD/2) applied immediately after single oral contaminantion with radiostrontium (0.2-0.4 uCi/mL) reduced skeletal retention of radiostrontium.

    KADIC M; VETERINARIA (SARAJAVO) 24 (2) 219-34 (1975)

    EXPTL USE: Alginated bread fed to mice increased (85)Sr concentration in blood, decreased urinary excretion and increased fecal excretion.

    VAN DER BORGHT ET AL; MINER METAB LAB, STUDIECENT KERNENERG CENT ETUDE ENERG NUCL, MOL, BELG

    EXPTL USE: Absorption in mice of strontium, barium, and radium was depressed more than that of calcium by alginates tested, include sodium alginate.

    HUMPHREYS ET AL; INT CONF STRONTIUM METAB (PAP) 2ND; VOL CONF-720818, 1973, 309-314

    For more Therapeutic Uses (Complete) data for ALGIN (8 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Apparently ... not decomposed or absorbed appreciably when ingested ...

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-155

    When propyleneglycol (14)C alginate or (14)C propylene glycol alginate ... dosed to mice, unhydrolyzed ester and alginate residue ... unabsorbed from GI tract; but any hydrolyzed propyleneglycol ... absorbed ... metabolized and eliminated ... single dose ... 1 g/kg ... excreted ... feces ... 5 days ...

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 343

    ... After a dose of 5 g/kg, traces of label were still present in rectum. Alginate prepared from laminaria digitata was unabsorbed by rats fed at a level of 10% of their daily diet.

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 343