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    Technical details about Sodium Bisulfite, learn more about the structure, uses, toxicity, action, side effects and more

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    Sodium Bisulfite

    APIs // Active Pharmaceutical Ingredients

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    2D Structure
    1. Also known as: 7631-90-5, Sodium hydrogen sulfite, Sodium hydrogensulfite, Sodium bisulphite, Sulfurous acid, monosodium salt, Sodium sulhydrate
    Molecular Formula
    HNaO3S
    Molecular Weight
    104.06  g/mol
    InChI Key
    DWAQJAXMDSEUJJ-UHFFFAOYSA-M
    FDA UNII
    TZX5469Z6I
    Sodium bisulfite has been used externally for parasitic skin diseases and as a gastrointestinal antiseptic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;hydrogen sulfite
    2.1.2 InChI
    InChI=1S/Na.H2O3S/c;1-4(2)3/h;(H2,1,2,3)/q+1;/p-1
    2.1.3 InChI Key
    DWAQJAXMDSEUJJ-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    OS(=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    TZX5469Z6I
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 7631-90-5

    2. Sodium Hydrogen Sulfite

    3. Sodium Hydrogensulfite

    4. Sodium Bisulphite

    5. Sulfurous Acid, Monosodium Salt

    6. Sodium Sulhydrate

    7. Monosodium Sulfite

    8. Sodium Hydrogen Sulphite

    9. Monosodic Sulphite

    10. Nahso3

    11. Liquid Of Sodium Bisulfite

    12. Ins No.222

    13. Tzx5469z6i

    14. Chembl1689285

    15. Chebi:26709

    16. Ins-222

    17. Sulfurous Acid, Sodium Salt (1:1)

    18. Nsc-60680

    19. E-222

    20. Uantax Sbs

    21. Sodium Bisulfite, Mixture Of Nahso3 And Na2s2o5

    22. Caswell No. 750

    23. Hydrogen Sodium Sulfite

    24. Sodium Bisulfite [jan]

    25. Sodium Hydrosulfite(dot)

    26. Mfcd00003530

    27. Bisulfite De Sodium [french]

    28. Ccris 3950

    29. Hsdb 724

    30. Sodium Hydrogensulphite

    31. Einecs 231-548-0

    32. Nsc 60680

    33. Epa Pesticide Chemical Code 078201

    34. Sodium Bisulfite [jan:nf]

    35. Sodiumbisulfit

    36. Unii-tzx5469z6i

    37. Sodium Hydrogensulphite (aqueous Solution)

    38. Ai3-08582

    39. Sodium Hydrogen Sulfite, Solution

    40. Sodium Bi-sulphite

    41. Sodiumhydrogensulfit

    42. Saures Natriumsulfit

    43. Natriumhydrogensulfit

    44. Sodiumhydrogensulphite

    45. Sodium Hydogen Sulfite

    46. Primaeres Natriumsulfit

    47. Sodium Hydrogen-sulfite

    48. Sodium;hydrogen Sulfite

    49. E222

    50. Sodium Bisulfite (tn)

    51. Sodium Bisulfite (jp17)

    52. Ec 231-548-0

    53. Sodium Hydrogen Sulfite Solution (45% Or Less)

    54. Dsstox_cid_14902

    55. Dsstox_gsid_47218

    56. Sodium Bisulfite [ii]

    57. Sodium Bisulfite [mi]

    58. Sodium Bisulfite, Acs Reagent

    59. Sodium Bisulfite [fcc]

    60. Sodium Bisulfite [hsdb]

    61. Sodium Bisulfite [inci]

    62. Dtxsid8034902

    63. Sodium Bisulfite [vandf]

    64. Sodium Bisulfite [mart.]

    65. Sodium Bisulfite [who-dd]

    66. Tox21_303826

    67. Akos015856800

    68. Db14015

    69. Ncgc00357103-01

    70. Sodium Bisulfite Solution, Purum, ~40%

    71. Bp-12336

    72. Sodium Bisulfite Aqueous Solution 35-40%

    73. Sodium Bisulfite, 37-40% Aqueous Solution

    74. Ft-0698943

    75. D02059

    76. Q407891

    77. Sodium Hydrogensulfite, Mixture Of Nahso3 And Na2s2o5

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 104.06 g/mol
    Molecular Formula HNaO3S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass103.95440935 g/mol
    Monoisotopic Mass103.95440935 g/mol
    Topological Polar Surface Area79.6 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity33.9
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mutagens; Anti-Infective Agents, Local; Antioxidants

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    DIETARY SUPPLEMENTS

    Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 1054

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    Antioxidants

    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

    Mutagens

    Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)

    5.2 Absorption, Distribution and Excretion

    EIGHTY TO 90% OF AN INTRAPERITONEAL DOSE IN RATS CAN BE ACCOUNTED FOR AS URINARY SULFATE IN 4 HR.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-123

    Approx 50% of the ingested bisulfite is absorbed from rat gut.

    American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1408

    Bisulfite is oxidized in vivo to sulfate, principally by hepatic sulfite oxidase, with lesser amounts metabolized by the kidneys, intestines, heart, & lungs. Some 70 to 95% of the radioactivity assoc with a 50 mg/kg oral bisulfite dose appeared in rodent & monkey urine within 3 days as sulfate. Only a small fraction (8-10%) of the absorbed bisulfite was eliminated intact.

    American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1408

    5.3 Metabolism/Metabolites

    Bisulfite is oxidized in vivo to sulfate, principally by hepatic sulfite oxidase, with lesser amounts metabolized by the kidneys, intestines, heart, & lungs.

    American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1408

    Rat liver contains 10 to 20 times more sulphite oxidase activity than does human liver.

    American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1409

    5.4 Mechanism of Action

    Sodium bisulfite is a mutagen that can specifically deaminate more than 96% of the cytosine residues in single-stranded DNA via formation of a 5,6-dihydrocytosine-6-sulfonate intermediate.

    PMID:7443525 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC324387 Wang RY et al; Nucleic Acids Res 8 (20): 4777-90 (1980)

    Bisulfite concn of 100 mM caused nearly complete inhibition of dNTP incorporation in calf thymus DNA. Preincubation of the various DNA synthesis assay components in 100 mM bisulfite showed that only preincubation of DNA polymerase I caused inhibition of DNA synthesis. There was a 7.5-fold decrease in the fidelity of DNA synthesis. It is hypothesized that sulfitolysis of the one disulfide group in DNA polymerase I by bisulfite might be responsible for reduced polymerase activity and accuracy. Effects of bisulfite on mutation frequency might be mediated by effects on the fidelity of DNA repair systems.

    PMID:6352068 Mallon RG, Rossman TG; Chem Biol Interact 46 (1): 101-8 (1983)

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