1. Sodium Chloride, (22)na
2. Sodium Chloride, (24)nacl
1. 7647-14-5
2. Salt
3. Table Salt
4. Halite
5. Saline
6. Rock Salt
7. Common Salt
8. Dendritis
9. Purex
10. Sodium Chloric
11. Iodized Salt
12. Top Flake
13. Sodium Chloride (nacl)
14. Hyposaline
15. Sodium Monochloride
16. Flexivial
17. Gingivyl
18. Slow Sodium
19. Sea Salt
20. Nacl
21. Ss Salt
22. Sodiumchloride
23. Natriumchlorid
24. Adsorbanac
25. Hypersal
26. Sodium;chloride
27. Trisodium Trichloride
28. White Crystal
29. H.g. Blending
30. Salt (ingredient)
31. Colyte
32. Isotonic Saline
33. Sodium Chloride (na4cl4)
34. Caswell No. 754
35. Normal Saline
36. Natrum Muriaticum
37. Extra Fine 200 Salt
38. Extra Fine 325 Salt
39. Sodium Chloride Brine, Purified
40. Arm-a-vial
41. Ccris 982
42. Dendritic Salt
43. Hsdb 6368
44. Epa Pesticide Chemical Code 013905
45. 14762-51-7
46. Sodium Chloride Solution
47. Mfcd00003477
48. Nsc-77364
49. Sodium Chloride, Hypertonic
50. Ls-1700
51. 10% Sodium Chloride Injection
52. Chebi:26710
53. 451w47iq8x
54. Ayr
55. Buffer Solution, Tisab
56. Sodium Chloride, Ultra Dry
57. Sodium Chloride Solution, 5 M
58. Natriumchlorid [german]
59. Broncho Saline
60. Sodium, Reference Standard Solution
61. Halite (nacl)
62. Sodium Chloride, Acs Reagent, >=99.0%
63. Sodium-36 Chloride
64. Einecs 231-598-3
65. Nsc 77364
66. Sodium Chloride Physiological Solution, Bioultra, Tablet
67. Sodium Chloride (na36cl)
68. Sodium Chloride [usp:jan]
69. Isotonic
70. Kochsalz
71. Mafiron
72. Rocksalt
73. Titrisol
74. Cloruro Sodico
75. Sodium-chloride
76. Solsel
77. Unii-451w47iq8x
78. Natrii Chloridum
79. Saline Solution
80. Sea Water
81. Watesal A
82. Uzushio Biryuu M
83. Chlorure De Sodium
84. Adsorbanac (tn)
85. Brinewate Superfine
86. Sodium Chloride In Plastic Container
87. Sodium Chloride Salt
88. Canners 999
89. Sodium Chloride Acs
90. Nacl Solution, 1m
91. 0.9% Saline
92. Sodium Chloride 3% In Plastic Container
93. Sodium Chloride 5% In Plastic Container
94. Suprasel Nitrite
95. 0.9% Saline Solution
96. Saline, Sodium Chloride
97. Sodium Chloride, Tablet
98. Sodium Chloride (8ci)
99. Sodium Chloride 0.9% In Plastic Container
100. Mono-sodium Chloride Salt
101. 0.9% Nacl
102. Sodium Chloride 0.45% In Plastic Container
103. Sodium Chloride 23.4% In Plastic Container
104. Sodium Chloride, Isotonic
105. Unii-vr5y7pdt5w
106. Salt (6ci,7ci)
107. Vr5y7pdt5w
108. Special Salt 100/95
109. Nacl 0.9%
110. Wln: Na G
111. Ec 231-598-3
112. Sodium Chloride [ii]
113. Sodium Chloride [mi]
114. Sodium Chloride 0.9% In Sterile Plastic Container
115. Sodium Chloride, Acs Reagent
116. B1655 [langual]
117. Sodium Chloride [jan]
118. Rns60 Component Saline
119. Sodium Chloride (jp17/usp)
120. Sodium Chloride [hsdb]
121. Sodium Chloride [inci]
122. Sodium Chloride Solution, 1 M
123. Sodium Chloride Solution, 2 M
124. Sodium Chloride, Optical Grade
125. Sodium Chloride [vandf]
126. Sodium Chloride Anhydrous
127. Bacteriostatic Sodium Chloride 0.9% In Plastic Container
128. Chembl1200574
129. Dtxsid3021271
130. Natrum Muriaticum [hpus]
131. Rns-60 Component Saline
132. Sodium Chloride Biochemical Grade
133. 7647-14-5 (solid)
134. Sodium Chloride [usp-rs]
135. Sodium Chloride [who-dd]
136. Sodium Chloride [who-ip]
137. Sodium Chloride, Anhydrous
138. Sodium Chloride Solution, 0.1 M
139. Sodium Chloride Solution, 0.85%
140. Sodium Chloride Solution, Isotonic
141. Nsc77364
142. Sodium Chloride, Ar, >=99.9%
143. Sodium Chloride, Lr, >=99.5%
144. Sodium Chloride, Spectroscopy Grade
145. Str02627
146. Sodium Chloride, Manac Incorporated
147. Sodium Chloride [green Book]
148. Sodium Chloride, >=99%, Ar Grade
149. Sodium Chloride [orange Book]
150. Akos024438089
151. Akos024457457
152. Sodium Chloride [ep Monograph]
153. Sodium Chloride, Bacteriostatic
154. 10% Sodium Chloride Solution In Water
155. Db09153
156. Sodium Chloride [usp Monograph]
157. Sodium Chloride Saturated Solution 26%
158. Sodium Chloride, Technical Grade, 95%
159. Sodium Chloride, Technical Grade, 97%
160. Natrii Chloridum [who-ip Latin]
161. Sodium Chloride, Ph. Eur., Usp Grade
162. Sodium Chloride, P.a., 99-100.5%
163. 32343-72-9
164. Chloride Standard Solution, 1 Mg/ml Cl-
165. Sodium Chloride, Nist(r) Srm(r) 919b
166. Sodium Chloride, Reagentplus(r), >=99%
167. Sodium Chloride, Usp, 99.0-100.5%
168. Sodium Chloride, Usp, 99.0-101.0%
169. B7288
170. Ft-0645114
171. Q2314
172. S0572
173. Sodium Chloride, 0.1n Standardized Solution
174. Sodium Chloride, Bioxtra, >=99.5% (at)
175. Sodium Chloride, Saj First Grade, >=99.0%
176. Sodium Chloride, Tested According To Ph.eur.
177. D02056
178. Sodium Chloride, 99.999% Trace Metals Basis
179. Sodium Chloride, Jis Special Grade, >=99.5%
180. Sodium Chloride, Trace Metals Grade, 99.99%
181. Isotopic Standard For Chlorine, Nist Srm 975a
182. Sodium Chloride, 5m Aqueous Solution, Autoclaved
183. Sodium Chloride, Vetec(tm) Reagent Grade, 99%
184. Sodanylium And Hydrochloric Acid, Ion(1-) (1:1)
185. Sodium Chloride, 5m Aqueous Solution, Rnase Free
186. Sodium Chloride, Puriss. P.a., >=99.5% (at)
187. Sodium Chloride, Nist(r) Srm(r) 2201, Ion-selective
188. Sodium Chloride Crystal Optic Disc, 13mm X 2mm, Unpolished
189. Sodium Chloride Crystal Optic Disc, 25mm X 5mm, Unpolished
190. Sodium Chloride Crystal Optic Disc, 32mm X 3mm, Unpolished
191. Sodium Chloride, 5m Aqueous Solution, Ph 8.0, Autoclaved
192. Sodium Chloride Crystal Optic Disc, 13mm X 1mm, Polished Both Sides
193. Sodium Chloride Crystal Optic Disc, 13mm X 2mm, Polished Both Sides
194. Sodium Chloride Crystal Optic Disc, 22mm X 4mm, Polished Both Sides
195. Sodium Chloride Crystal Optic Disc, 25mm X 2mm, Polished Both Sides
196. Sodium Chloride Crystal Optic Disc, 25mm X 4mm, Polished Both Sides
197. Sodium Chloride Crystal Optic Disc, 32mm X 3mm, Polished Both Sides
198. Sodium Chloride Crystal Optic Disc, 38mm X 6mm, Polished Both Sides
199. Sodium Chloride, Bioultra, For Molecular Biology, >=99.5% (at)
200. Sodium Chloride, Puriss. P.a., >=99.5% (at), Powder Or Crystals
201. Sodium Chloride, Reagent Grade, >=98%, +80 Mesh Particle Size
202. Sodium Chloride, United States Pharmacopeia (usp) Reference Standard
203. Sodium Standard For Aas, Ready-to-use, Traceable To Bam, In H2o
204. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm, Unpolished
205. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm, Unpolished
206. Sodium Chloride Crystal Optic Rectangle, 41mm X 23mm X 6mm, Unpolished
207. Sodium Chloride Solution, Bioultra, For Molecular Biology, ~5 M In H2o
208. Sodium Chloride Solution, Technical, ~26% (saturated In Water At 20c, At)
209. Sodium Chloride, Anhydrous, Beads, -10 Mesh, 99.99% Trace Metals Basis
210. Sodium Chloride, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis
211. Sodium Chloride, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.5%
212. Sodium Chloride, Random Crystals, Optical Grade, 99.98% Trace Metals Basis
213. Sodium Chloride Crystal Optic Disc, 32mm X 3mm (drilled), Polished Both Sides
214. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm (drilled), Polished Both Sides
215. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm, Polished Both Sides
216. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm, Polished Both Sides
217. Sodium Chloride Solution, 0.9% In Water, Bioxtra, Suitable For Cell Culture
218. Sodium Chloride, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), >=99%
219. Sodium Chloride, Anhydrous, Redi-dri(tm), Free-flowing, Acs Reagent, >=99%
220. Sodium Chloride, Bioperformance Certified, >=99% (titration), Cell Culture Tested
221. Sodium Chloride, Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.0-100.5%
222. Sodium Chloride, Pharmaceutical Secondary Standard; Certified Reference Material
223. Sodium Chloride, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.5%
224. Sodium Atomic Spectroscopy Standard Concentrate 1.00 G Na, 1.00 G/l, For 1 L Standard Solution, Analytical Standard
225. Sodium Atomic Spectroscopy Standard Concentrate 10.00 G Na, 10.00 G/l, For 1 L Standard Solution, Analytical Standard
226. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm (drilled), Polished Both Sides
227. Sodium Chloride Solution, 5 M In H2o, Bioreagent, For Molecular Biology, Suitable For Cell Culture
228. Sodium Chloride, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Plant Cell Culture, >=99%
229. Sodium Chloride, Certified Reference Material For Titrimetry, Certified By Bam, According To Iso 17025, >=99.5%
230. Sodium Chloride, For Molecular Biology, Dnase, Rnase, And Protease, None Detected, >=98% (titration)
231. Sodium Chloride, Pharmagrade, Usp, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production.
232. Sodium Chloride, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.0-100.5% (calc. To The Dried Substance), <=0.00002% Al
233. Sodium Standard Solution, Suitable For Atomic Absorption Spectrometry, 1000 Ppm Na, 1 Mg/ml Na
| Molecular Weight | 58.44 g/mol |
|---|---|
| Molecular Formula | ClNa |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 57.9586220 g/mol |
| Monoisotopic Mass | 57.9586220 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 2 |
| Formal Charge | 0 |
| Complexity | 2 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 6 | |
|---|---|
| Drug Name | Broncho saline |
| PubMed Health | Sodium Chloride (By breathing) |
| Drug Classes | Antiasthma, Respiratory Agent |
| Drug Label | 14.6% Sodium Chloride Injection, USP Additive Solution is a sterile, nonpyrogenic, concentrated solution for intravenous administration ONLY AFTER DILUTION to replenish electrolytes. The preparations contain either 2.92 or 5.84 g of sodium chloride (... |
| Active Ingredient | Sodium chloride |
| Dosage Form | Aerosol, metered |
| Route | Inhalation |
| Strength | 0.9% |
| Market Status | Over the Counter |
| Company | Blairex |
| 2 of 6 | |
|---|---|
| Drug Name | Sodium chloride |
| PubMed Health | Sodium Chloride |
| Drug Classes | Antiasthma, Osmotherapy Agent, Parenteral Electrolyte, Sodium, Respiratory Agent, Sodium Supplement |
| Active Ingredient | Sodium chloride |
| Dosage Form | Injectable |
| Route | injection |
| Strength | 10ml |
| Market Status | Prescription |
| Company | Taro Pharms Ireland |
| 3 of 6 | |
|---|---|
| Drug Name | Sodium chloride in plastic container |
| Active Ingredient | Sodium chloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 2.5meq/ml |
| Market Status | Prescription |
| Company | Hospira |
| 4 of 6 | |
|---|---|
| Drug Name | Broncho saline |
| PubMed Health | Sodium Chloride (By breathing) |
| Drug Classes | Antiasthma, Respiratory Agent |
| Drug Label | 14.6% Sodium Chloride Injection, USP Additive Solution is a sterile, nonpyrogenic, concentrated solution for intravenous administration ONLY AFTER DILUTION to replenish electrolytes. The preparations contain either 2.92 or 5.84 g of sodium chloride (... |
| Active Ingredient | Sodium chloride |
| Dosage Form | Aerosol, metered |
| Route | Inhalation |
| Strength | 0.9% |
| Market Status | Over the Counter |
| Company | Blairex |
| 5 of 6 | |
|---|---|
| Drug Name | Sodium chloride |
| PubMed Health | Sodium Chloride |
| Drug Classes | Antiasthma, Osmotherapy Agent, Parenteral Electrolyte, Sodium, Respiratory Agent, Sodium Supplement |
| Active Ingredient | Sodium chloride |
| Dosage Form | Injectable |
| Route | injection |
| Strength | 10ml |
| Market Status | Prescription |
| Company | Taro Pharms Ireland |
| 6 of 6 | |
|---|---|
| Drug Name | Sodium chloride in plastic container |
| Active Ingredient | Sodium chloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 2.5meq/ml |
| Market Status | Prescription |
| Company | Hospira |
Sodium chloride injections are used as a source of sodium chloride and water for hydration. Sodium chloride is used in the prevention or treatment of deficiencies of sodium and chloride ions and in the prevention of muscle cramps and heat prostration resulting from excessive perspiration during exposure to high temperature. Sodium chloride is also used to treat deficiencies of sodium and chloride caused by excessive diuresis or excessive salt restriction.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758
0.45% Sodium chloride injection is used principally as a hydrating solution and may be used to assess renal function status, since more water is provided than is required for excretion of salt. 0.45% Sodium chloride injection is also used in the management of hyperosmolar diabetes.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758
0.9% Sodium chloride injection is used for extracellular fluid replacement and in the management of metabolic alkalosis in the presence of fluid loss and mild sodium depletion. 0.9% Sodium chloride injection (normal saline) is also used as a priming fluid for hemodialysis procedures and to initiate and terminate blood transfusions.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758
Hypertonic (i.e., 3%, 5%) sodium chloride injection is used in the management of severe sodium chloride depletion when rapid electrolyte restoration is essential. Severe sodium chloride depletion may occur in the presence of heart failure or renal impairment, or during surgery or postoperatively. In these conditions, chloride loss often exceeds sodium loss. Hypertonic sodium chloride injections are also used in the management of hyponatremia and hypochloremia resulting from administration of sodium-free fluids during fluid and electrolyte therapy; in the management of extreme dilution of extracellular fluid following excessive water intake (e.g., that resulting from multiple enemas or perfusion of irrigating solutions into open venous sinuses during transurethral prostatic resections); and in the emergency treatment of severe sodium chloride depletion resulting from excess sweating, vomiting, diarrhea, and other conditions.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758
For more Therapeutic Uses (Complete) data for SODIUM CHLORIDE (13 total), please visit the HSDB record page.
Bacteriostatic sodium chloride injection containing benzyl alcohol as a preservative (antimicrobial agent) should not be used for diluting or reconstituting drugs for administration in neonates nor should it be used to flush intravascular catheters in neonates. Several deaths have been reported in neonates weighing less than 2.5 kg in whom bacteriostatic sodium chloride for injection containing 0.9% benzyl alcohol was used for flushing IV catheters; some of these neonates received additional benzyl alcohol when bacteriostatic sodium chloride injection was used to dilute or reconstitute drugs. The deaths were usually preceded by a syndrome that included metabolic acidosis, CNS depression, respiratory distress progressing to gasping respiration, hypotension, renal failure, and, occasionally, seizures and intracranial hemorrhage. High concentrations of benzyl alcohol, benzoic acid, and hippuric acid (a metabolite) were present in blood and urine in these neonates. Benzyl alcohol toxicity apparently was caused by administration of relatively large daily doses (99-404 mg/kg daily) of the preservative in proportion to the neonate's weight. Although these neonates had biochemical evidence of benzyl alcohol toxicity, they also had serious underlying conditions.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759
Sodium chloride is contraindicated in patients with conditions in which administration of sodium and chloride is detrimental. Sodium chloride 3 and 5% injections are also contraindicated in the presence of increased, normal, or only slightly decreased serum electrolyte concentrations.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759
Sodium chloride should be used with extreme caution, if at all, in patients with congestive heart failure or other edematous or sodium-retaining conditions, in patients with severe renal insufficiency, in patients with liver cirrhosis, and in patients receiving corticosteroids or corticotropin; particular caution is necessary in geriatric or postoperative patients. IV administration of sodium chloride may cause fluid and/or solute overload resulting in dilution of serum electrolytes, overhydration, congestive conditions, or pulmonary edema. The risk of dilutional conditions is inversely proportional to the electrolyte concentration administered, and the risk of solute overload and resultant congestive conditions with peripheral and/or pulmonary edema is directly proportional to the electrolyte concentration administered. The manufacturers warn that excessive IV administration of sodium chloride may result in hypokalemia.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759
Changes in fluid balance, electrolyte concentrations, and acid-base balance should be evaluated clinically and via periodic laboratory determinations during prolonged therapy with sodium chloride and in patients whose condition warrants such evaluation. Substantial changes may require additional electrolyte supplements or other appropriate therapy. Additional electrolyte supplementation may also be required in patients with substantial electrolyte losses resulting from conditions such as protracted nasogastric suctioning, vomiting, diarrhea, or GI fistula drainage.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759
For more Drug Warnings (Complete) data for SODIUM CHLORIDE (12 total), please visit the HSDB record page.
The estimated fatal dose of sodium chloride is approximately 0.75 to 3.00 g/kg.
Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057
An estimated dose of more than 400 mEq/kg resulted in brain injury and death in a 2 year old child given a salt water solution to induce emesis.
Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057
This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.
Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.
A - Alimentary tract and metabolism
A12 - Mineral supplements
A12C - Other mineral supplements
A12CA - Sodium
A12CA01 - Sodium chloride
B - Blood and blood forming organs
B05 - Blood substitutes and perfusion solutions
B05C - Irrigating solutions
B05CB - Salt solutions
B05CB01 - Sodium chloride
B - Blood and blood forming organs
B05 - Blood substitutes and perfusion solutions
B05X - I.v. solution additives
B05XA - Electrolyte solutions
B05XA03 - Sodium chloride
S - Sensory organs
S01 - Ophthalmologicals
S01X - Other ophthalmologicals
S01XA - Other ophthalmologicals
S01XA03 - Sodium chloride, hypertonic
Absorption
Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.
Route of Elimination
Substantially excreted by the kidneys.
Volume of Distribution
The volume of distribution is 0.64 L/kg.
The primary route of sodium excretion is the urine; additional excretion occurs in sweat and feces. The kidney filters sodium a the glomerulus, but 60% to 70% is reabsorbed in the proximal tubules along with bicarbonate and water. Another 25% to 30% is reabsorbed in the loop of Henle, along with chloride and water. In the distal tubules, aldosterone modulates the reabsorption of sodium and, indirectly, chloride. The renal threshold for sodium is 110 to 130 mEq/L. Less than 1% of the filtered sodium is excreted in the urine.
Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057
Sodium is rapidly absorbed from the GI tract; it is also absorbed from rectal enemas. Intestinal wall absorption occurs via the Na+, K+-adenosine triphosphatase system that is augmented by aldosterone and desoxycorticosterone acetate. Sodium is not bound by plasma proteins. The volume of distribution is 0.64 L/kg.
Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057
In one study using radiolabeled 20% sodium chloride injection, most of the drug concentrated in the decidua and the fetal part of the placenta following intra-amniotic injection. Following intra-amniotic administration of 20% sodium chloride injection, some of the drug diffuses into the maternal blood.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 3323
Atrichial sweat glands ... are the organs by which considerable body water and electrolytes, mainly sodium chloride, are lost.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 8:69
For more Absorption, Distribution and Excretion (Complete) data for SODIUM CHLORIDE (6 total), please visit the HSDB record page.
The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.
17 minutes
Sodium and chloride major electrolytes of the fluid compartment outside of cells (i.e., extracellular) work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.
Intra-amniotic instillation of 20% sodium chloride injection induces abortion and fetal death. Although the mechanism has not been conclusively determined, some studies indicate that the drug's abortifacient activity may be mediated by prostaglandins released from decidual cells damaged by hypertonic solutions of sodium chloride. Hypertonic sodium chloride-induced uterine contractions are usually sufficient to cause evacuation of both the fetus and placenta; however, abortion may be incomplete in 25-40% of patients. /20% injection/
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 3323
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