Sodium Cromoglicate

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Also known as: 15826-37-6, Sodium cromoglycate, Disodium cromoglycate, Sodium cromoglicate, Sodium cromolyn, Cromolyn sodium salt

Molecular Formula

C₂₃H₁₄Na₂O₁₁

Molecular Weight

512.3 g/mol

InChI Key

VLARUOGDXDTHEH-UHFFFAOYSA-L

FDA UNII

Q2WXR1I0PK

A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate

2.1.2 InChI

InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2

2.1.3 InChI Key

VLARUOGDXDTHEH-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

Q2WXR1I0PK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aarane

2. Acid, Cromoglicic

3. Acid, Cromoglycic

4. Bicromat Spray

5. Cromoglicic Acid

6. Cromoglycate

7. Cromoglycate, Disodium

8. Cromoglycate, Sodium

9. Cromoglycic Acid

10. Cromolyn

11. Disodium Cromoglycate

12. Fpl 670

13. Fpl-670

14. Fpl670

15. Intal

16. Lomudal

17. Nalcrom

18. Nasalcrom

19. Opticrom

20. Sodium Cromoglycate

21. Vicrom

2.3.2 Depositor-Supplied Synonyms

1. 15826-37-6

2. Sodium Cromoglycate

3. Disodium Cromoglycate

4. Sodium Cromoglicate

5. Sodium Cromolyn

6. Cromolyn Sodium Salt

7. Gastrocrom

8. Nasalcrom

9. Opticrom

10. Intal

11. Cromolyn Disodium Salt

12. Cromoptic

13. Crolom

14. Cromoglycate Disodium

15. Natrii Cromoglicas

16. Natrium Cromoglicat

17. Lomudal

18. Nalcrom

19. Aarane

20. Fpl-670

21. Chromolyn Sodium

22. Cromoglicate Sodium

23. Cromolyn (sodium)

24. Aararre

25. Frenasma

26. Lomudas

27. Lomusol

28. Nebulasma

29. Rynacrom

30. Nasmil

31. Astilyn

32. Cromo Asma Aerosol

33. Disodium Cromolyn

34. Dinatrium Cromoglicicum

35. Fpl 670

36. Fpl.670

37. Chebi:128458

38. Q2wxr1i0pk

39. Cromoglicic Acid;duracroman

40. Disodium Cromoglycate;fpl-670

41. Dinatrium Salz Von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan

42. Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4h-1-benzopyran-2-carboxylate)

43. Disodium 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylate)

44. Nsc-109500

45. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, Disodium Salt)

46. Gastrofrenal

47. Lomuda

48. Intal Nebulizer

49. Cas-15826-37-6

50. Dsstox_cid_24554

51. Dsstox_rid_80311

52. Cromolyn Sodium Hydrate

53. Dsstox_gsid_44554

54. Disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate

55. Cromolyn Sodium [usan]

56. Inostral (anti-asthmatic)

57. Natrium Cromoglicat [german]

58. Ccris 3194

59. Ncgc00021142-02

60. 4h-1-benzopyran-2-carboxylicacid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, Sodium Salt (1:2)

61. Einecs 239-926-7

62. Unii-q2wxr1i0pk

63. Sodium Cromoglicate [jan]

64. Nsc 109500

65. Cromolyn Sodium [usan:usp]

66. Cromlyn Sodio

67. Cromoglicinsaeure, Dinatriumsalz

68. Cromolina Sodica

69. Cromolyn Na

70. Cromolyne Sodique

71. 1,3-di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol

72. Methyl3-butynoate

73. Disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4h-chromene-2-carboxylate)

74. Gastrocrom (tn)

75. Prestwick_996

76. Mfcd00057744

77. Cromoglicato De Sodio

78. Intal (tn)

79. 5,5'-(2-hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic Acid)

80. Cromolyn Sodium (usp)

81. Chembl74

82. 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis(4-oxo-4h-1-benzopyran-2-carboxylic Acid) Disodium Salt

83. Epitope Id:122681

84. Dinatrium Salz Von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [german]

85. Schembl7500

86. 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylic Acid) Disodium Salt

87. Cromoglycate,cromoglycic Acid

88. Sodium Cromoglicate (jp17)

89. Spectrum1500210

90. Cromolyn Sodium [vandf]

91. Fpl 670 (cromolyn) Disodium

92. Disodium Cromolyn [inci]

93. Dtxsid7044554

94. Hms502k19

95. Cromolyn Sodium [usp-rs]

96. Hms1570d05

97. Hms1920a18

98. Hms2089n09

99. Hms2091i06

100. Hms2097d05

101. Hms3714d05

102. Bcp12933

103. Cromolyn Disodium Salt [mi]

104. Sodium Cromoglicate [mart.]

105. Tox21_110863

106. Tox21_302003

107. Ccg-40261

108. Cromoglicate Sodium [who-dd]

109. S1911

110. Sodium Cromoglicate [who-ip]

111. Cromolyn Sodium [orange Book]

112. Akos015895760

113. Akos015913923

114. Tox21_110863_1

115. Cromolyn Sodium [usp Monograph]

116. Ks-5299

117. Ncgc00017083-01

118. Ncgc00017083-02

119. Ncgc00017083-03

120. Ncgc00022858-08

121. Ncgc00094633-01

122. Ncgc00094633-02

123. Ncgc00255950-01

124. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, Disodium Salt

125. Ac-18734

126. Natrii Cromoglicas [who-ip Latin]

127. Sodium Cromoglicate [ep Monograph]

128. B3300

129. Ft-0602030

130. D00526

131. A809913

132. J-009487

133. Q10261779

134. Sodium 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4h-chromene-2-carboxylate)

135. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, Disodium Salt

136. Disodium 5-[3-(2-carboxylato-4-oxo-4h-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4h-2-chromenecarboxylate

137. Disodium 5-{3-[(2-carboxylato-4-oxo-4h-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4h-chromene-2-carboxylate

138. Sodium 5-[3-(2-carboxy-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylic Acid;sodium Cromoylycate

139. Sodium Salt Of 5-[3-(2-carboxy-4-oxo-4h-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4h-2-chromenecarboxylic Acid

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₁₄Na₂O₁₁
Molecular Weight	512.3 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	6
Exact Mass	512.03314982 g/mol
Monoisotopic Mass	512.03314982 g/mol
Topological Polar Surface Area	172 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	824
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Crolom
PubMed Health	Cromolyn (Into the eye)
Drug Classes	Ophthalmologic Agent
Drug Label	Crolom (cromolyn sodium ophthalmic solution USP, 4%) is a clear, colorless, sterile solution for topical ophthalmic use. Cromolyn sodium is represented by the following structural formula:C23H14Na2O11...
Active Ingredient	Cromolyn sodium
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	4%
Market Status	Prescription
Company	Bausch And Lomb

2 of 6
Drug Name	Cromolyn sodium
PubMed Health	Cromolyn
Drug Classes	Antiasthma, Gastrointestinal Agent, Nasal Agent, Ophthalmologic Agent
Drug Label	The active ingredient of cromolyn sodium inhalation solution, USP is cromolyn sodium, USP. It is an inhaled anti-inflammatory agent for the preventive management of asthma. Cromolyn sodium is chemically designated as disodium 5,5'- [(2-hydroxytrimeth
Active Ingredient	Cromolyn sodium
Dosage Form	Solution/drops; Spray, metered; Concentrate; Solution
Route	Nasal; Inhalation; Ophthalmic; Oral
Strength	5.2mg/spray; 100mg/5ml; 4%; 10mg/ml
Market Status	Over the Counter; Prescription
Company	Wockhardt; Alcon; Teva Pharms; Micro Labs Ltd India; Pack Pharms; Bausch And Lomb; Perrigo; Mylan Speclt; Akorn

3 of 6
Drug Name	Gastrocrom
Drug Label	Each 5 mL ampule of GASTROCROM contains 100 mg cromolyn sodium, USP, in purified water. Cromolyn sodium is a hygroscopic, white powder having little odor. It may leave a slightly bitter aftertaste. GASTROCROM (cromolyn sodium, USP) Oral Concentrate i...
Active Ingredient	Cromolyn sodium
Dosage Form	Concentrate
Route	Oral
Strength	100mg/5ml
Market Status	Prescription
Company	Meda Pharms

4 of 6
Drug Name	Crolom
PubMed Health	Cromolyn (Into the eye)
Drug Classes	Ophthalmologic Agent
Drug Label	Crolom (cromolyn sodium ophthalmic solution USP, 4%) is a clear, colorless, sterile solution for topical ophthalmic use. Cromolyn sodium is represented by the following structural formula:C23H14Na2O11...
Active Ingredient	Cromolyn sodium
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	4%
Market Status	Prescription
Company	Bausch And Lomb

5 of 6
Drug Name	Cromolyn sodium
PubMed Health	Cromolyn
Drug Classes	Antiasthma, Gastrointestinal Agent, Nasal Agent, Ophthalmologic Agent
Drug Label	The active ingredient of cromolyn sodium inhalation solution, USP is cromolyn sodium, USP. It is an inhaled anti-inflammatory agent for the preventive management of asthma. Cromolyn sodium is chemically designated as disodium 5,5'- [(2-hydroxytrimeth
Active Ingredient	Cromolyn sodium
Dosage Form	Solution/drops; Spray, metered; Concentrate; Solution
Route	Nasal; Inhalation; Ophthalmic; Oral
Strength	5.2mg/spray; 100mg/5ml; 4%; 10mg/ml
Market Status	Over the Counter; Prescription
Company	Wockhardt; Alcon; Teva Pharms; Micro Labs Ltd India; Pack Pharms; Bausch And Lomb; Perrigo; Mylan Speclt; Akorn

6 of 6
Drug Name	Gastrocrom
Drug Label	Each 5 mL ampule of GASTROCROM contains 100 mg cromolyn sodium, USP, in purified water. Cromolyn sodium is a hygroscopic, white powder having little odor. It may leave a slightly bitter aftertaste. GASTROCROM (cromolyn sodium, USP) Oral Concentrate i...
Active Ingredient	Cromolyn sodium
Dosage Form	Concentrate
Route	Oral
Strength	100mg/5ml
Market Status	Prescription
Company	Meda Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Mast Cell Stabilizers

Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)

Anti-Asthmatic Agents

Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Mast Cell Stabilizer [EPC]; Decreased Histamine Release [PE]

Sodium Cromoglicate

Sodium Cromoglicate

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ACTIVE PHARMA INGREDIENTS

20 API Suppliers

10 USDMF

6 CEP/COS

4 JDMF

15 NDC API

12 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

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4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

97 FDF Dossiers

31 FDA Orange Book

43 Europe

3 Canada

1 Australia

6 South Africa

13 Listed Dossiers

RELATED EXCIPIENT COMPANIES

3 Actylis

1 Finar

EXCIPIENTS BY APPLICATIONS

2 Parenteral

2 Solubilizers

DIGITAL CONTENT

10 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

23 Finished Drug Prices

MARKET PLACE

16 APIs

4 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM

1 USP

3 Others

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