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    Sodium Hyaluronate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Hyaluronic acid, sodium salt, Hyaluronic acid sodium, Kopuron, Healon, Hyalgan, Hyalurone sodium
    Molecular Formula
    C28H44N2NaO23+
    Molecular Weight
    799.6  g/mol
    InChI Key
    YWIVKILSMZOHHF-QJZPQSOGSA-N
    A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
    2.1.2 InChI
    InChI=1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
    2.1.3 InChI Key
    YWIVKILSMZOHHF-QJZPQSOGSA-N
    2.1.4 Canonical SMILES
    CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
    2.1.5 Isomeric SMILES
    CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Acid, Hyaluronic

    2. Amo Vitrax

    3. Amvisc

    4. Biolon

    5. Etamucine

    6. Healon

    7. Hyaluronate Sodium

    8. Hyaluronate, Sodium

    9. Hyaluronic Acid

    10. Hyvisc

    11. Luronit

    12. Vitrax, Amo

    2.2.2 Depositor-Supplied Synonyms

    1. Hyaluronic Acid, Sodium Salt

    2. Hyaluronic Acid Sodium

    3. Kopuron

    4. Healon

    5. Hyalgan

    6. Hyalurone Sodium

    7. 6-[3-acetamido-2-[6-[3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic Acid

    8. Sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic Acid

    9. Equron (veterinary)

    10. Synacid (veterinary)

    11. Arthrease

    12. Cystistat

    13. Hyalart

    14. Hyalein

    15. Hyalovet

    16. Hyladerm

    17. Khionat

    18. Monovisc

    19. Nidelon

    20. Orthovisc

    21. Ostenil

    22. Provisc

    23. Sinovial

    24. Supartz

    25. Suvenyl

    26. Hyasol

    27. Hyladerm Khionat

    28. Nrd101

    29. Ha

    30. Hyaluronsan Ha-lq

    31. Bio Hyaluro 12

    32. Euflexxa Injection

    33. Euflexxa

    34. Ccris 4127

    35. Hyaluronate Sodium [usan:jan]

    36. Sodium Hyaluronate Hmw

    37. Unii-yse9ppt4th

    38. Si-4402

    39. Sl-1010

    40. Synacid

    41. Equron

    42. Chlamyhyaluronic Acid Sodium Salt

    43. Sl 1010

    44. Hyalauronic Acid 99%

    45. Yse9ppt4th

    46. Gtpl4954

    47. Sodium Hyaluronate (food Grade)

    48. Sodium Hyaluronate (cosmetic Grade)

    49. Akos015896610

    50. Sodium Hyaluronate, Low Molecular Weight

    51. Sodium Hyaluronate, High Molecular Weight

    52. Q27078001

    53. (3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-4-[(2s,3r,4s,6s)-6-carboxy-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dih

    54. Sodium (2s,3s,4r,5r,6r)-3-{[(2s,3r,4r,5s,6r)-4-{[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic Acid

    2.3 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 799.6 g/mol
    Molecular Formula C28H44N2NaO23+
    Hydrogen Bond Donor Count14
    Hydrogen Bond Acceptor Count23
    Rotatable Bond Count12
    Exact Mass799.22325494 g/mol
    Monoisotopic Mass799.22325494 g/mol
    Topological Polar Surface Area400 Ų
    Heavy Atom Count54
    Formal Charge1
    Complexity1300
    Isotope Atom Count0
    Defined Atom Stereocenter Count20
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adjuvants, Immunologic

    Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

    Viscosupplements

    Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS. (See all compounds classified as Viscosupplements.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Vitamin B 6 [Chemical/Ingredient]; Vitamin B6 Analog [EPC]; Analogs/Derivatives [Chemical/Ingredient]